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Engineered exosomes from different sources for cancer-targeted therapy
Signal Transduction and Targeted Therapy, 2023 Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules.
exaly +2 more sources
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Nature, 2017 The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated by all cells, and are naturally present in the blood. Here we show that enhanced retention
Sushrut Kamerkar +2 more
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Exosomes: key players in cancer and potential therapeutic strategy
Signal Transduction and Targeted Therapy, 2020 Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long noncoding RNA, circular RNA, etc., which play a crucial role ...
Yong-Guang Tao, Yiqun Jiang
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Artificial exosomes for translational nanomedicine
Journal of Nanobiotechnology, 2021 Exosomes are lipid bilayer membrane vesicles and are emerging as competent nanocarriers for drug delivery. The clinical translation of exosomes faces many challenges such as massive production, standard isolation, drug loading, stability and quality ...
Yong-Jiang Li +7 more
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Application of exosomes as liquid biopsy in clinical diagnosis
Signal Transduction and Targeted Therapy, 2020 Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small extracellular vesicles with sizes between 30–150 nm.
Biting Zhou, Kailun Xu, Xi Zheng
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Emerging Role of Exosomes in the Joint Diseases
Cellular Physiology and Biochemistry, 2018 Exosomes are a subset of small, membrane-bound extracellular vesicles that are important for communication among cells. They originate from the cell membrane during endocytic internalization, and are stable in biological fluids, including blood and ...
Zeng Li +5 more
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Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
Nature Biomedical Engineering, 2019 Exosomes are attractive as nucleic-acid carriers because of their favourable pharmacokinetic and immunological properties and their ability to penetrate physiological barriers that are impermeable to synthetic drug-delivery vehicles.
Zhaogang Yang, Yifan Wang, Jingyao Sun
exaly +2 more sources
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Nature, 2015 Sonia A Melo +2 more
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Vaccines, 2023 Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has presented numerous challenges to global health.
Quan Zhang +10 more
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The Machinery of Exosomes: Biogenesis, Release, and Uptake
International Journal of Molecular Sciences, 2023 Exosomes are a subtype of membrane-contained vesicles 40–200 nm in diameter that are secreted by cells into their surroundings. By transporting proteins, lipids, mRNA, miRNA, lncRNA, and DNA, exosomes are able to perform such vital functions as ...
S. V. Krylova, Daorong Feng
semanticscholar +1 more source