Results 11 to 20 of about 158,436 (362)
Frontiers in Immunology, 2020 Sepsis is a severe state of infection with high mortality. Pathogen-associated molecular patterns and damage-associated molecular patterns (DAMPs) initiate dysregulated systemic inflammation upon binding to pattern recognition receptors. Exosomes are endosome-derived vesicles, which carry proteins, lipids and nucleic acids, and facilitate intercellular
Atsushi Murao +6 more
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Journal of Nanobiotechnology, 2022 Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (hucMSC-sEVs) have been demonstrated as a therapeutic agent to prevent and treat cisplatin-induced acute kidney injury (AKI).
Peipei Wu +11 more
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Emerging Technologies for Cancer Research: Towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models [PDF]
Current Medicinal Chemistry, 2018, 2021 In the present review, we describe three hot topics in cancer research such as circulating tumor cells, exosomes, and 3D environment models. The first section is dedicated to microfluidic platforms for detecting circulating tumor cells, including both affinity based methods that take advantage of antibodies and aptamers, and label free approaches ...
arxiv +1 more source
The biology, function, and biomedical applications of exosomes
Science, 2020 Clinical uses of cellular communication Exosomes are a type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them.
R. Kalluri, Valerie S. LeBleu
semanticscholar +1 more source
Cell, 2005 In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et al.
Jensen, Torben Heick, Moore, Claire
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The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease [PDF]
Frontiers in Cell and Developmental Biology, 2021 Exosomes are small vesicles (30–150 nm in diameter) enclosed by a lipid membrane bilayer, secreted by most cells in the body. They carry various molecules, including proteins, lipids, mRNA, and other RNA species, such as long non-coding RNA, circular RNA, and microRNA (miRNA). miRNAs are the most numerous cargo molecules in the exosome.
Bo Li +9 more
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Exosomes as a new frontier of cancer liquid biopsy
Molecular Cancer, 2022 Liquid biopsy, characterized by minimally invasive detection through biofluids such as blood, saliva, and urine, has emerged as a revolutionary strategy for cancer diagnosis and prognosis prediction.
Dan Yu +7 more
semanticscholar +1 more source
EMBnet.journal, 2020 Extracellular vesicles have been the focus of a large number of studies in the past five years. Exosomes, a subgroup of extracellular vesicles, are of particularly high interest because they partake in a wide number of biological pathways. Produced by a variety of cells, exosomes have an important role in both physiological and pathological conditions.
Mitsis, Thanasis +6 more
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Engineering exosomes for targeted drug delivery
Theranostics, 2021 Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation of materials. Therapeutics, such as small molecules or nucleic acid drugs, can be incorporated into exosomes and then delivered to specific types of cells or ...
Yujie Liang +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2014 Recent studies have highlighted the importance of cross-talk between our immune systems and our gut microbiota, the complex community of over 100 trillion commensal microorganisms (bacteria, archaea, fungi, and protozoans) that resides in the human gastrointestinal tract and which numbers about 10 times the total cells in the human body (1).
John Smythies, Lesley E. Smythies
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