Results 71 to 80 of about 81,192 (267)

The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. [PDF]

, 2017
In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS).
Atasoy, Ulus, Chen, Jing, Cramer, Carole, Drew, Paul D., Gorospe, Myriam, Martindale, Jennifer L., Yu, Shiguang   +6 more
core   +2 more sources

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

Opposing T cell responses in experimental autoimmune encephalomyelitis [PDF]

Nature, 2019
Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ T cells in the blood and central nervous system, similar to gluten-challenge studies of patients with coeliac disease.
Jorge R. Oksenberg, Yueh-hsiu Chien, Naresha Saligrama, Stephen L. Hauser, Vinit B. Mahajan, Vinit B. Mahajan, Mark M. Davis, Winnie Yao, Lars M. Steinmetz, Lars M. Steinmetz, Juliana Idoyaga, Michael J. Sikora, Fan Zhao, Ricardo A. Fernandes, David M. Louis, K. Christopher Garcia, William S. Serratelli, Xuhuai Ji   +17 more
openaire   +5 more sources

R‐flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice

EMBO Molecular Medicine, 2014
R‐flurbiprofen is the non‐cyclooxygenase inhibiting R‐enantiomer of the non‐steroidal anti‐inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease.
Katja Schmitz, Natasja de Bruin, Philipp Bishay, Julia Männich, Annett Häussler, Christine Altmann, Nerea Ferreirós, Jörn Lötsch, Alfred Ultsch, Michael J Parnham, Gerd Geisslinger, Irmgard Tegeder   +11 more
doaj   +1 more source

Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. [PDF]

, 2010
Peroxisome proliferator-activated receptors (PPARs; PPAR-alpha, PPAR-delta, and PPAR-gamma) comprise a family of nuclear receptors that sense fatty acid levels and translate this information into altered gene transcription.
Axtell, Robert, Bhat, Roopa, Chawla, Ajay, Dugas, Jason C, Dunn, Shannon E, Johnson, Amanda, Moshkova, Marina, Mukundan, Lata, Nguyen, Kim, Sobel, Raymond A, Steinman, Lawrence, Straus, Daniel S   +11 more
core   +3 more sources

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Hyperphosphorylation and Aggregation of Tau in Experimental Autoimmune Encephalomyelitis [PDF]

Journal of Biological Chemistry, 2004
Axonal damage is a major morphological correlate and cause of permanent neurological deficits in patients with multiple sclerosis (MS), a multifocal, inflammatory and demyelinating disease of the central nervous system. Hyperphosphorylation and pathological aggregation of microtubule-associated protein tau is a common feature of many neurodegenerative ...
Anja Schneider, Anja Schneider, Doron Merkler, Martin M. Herrmann, Katarina Trajkovic, Katarina Trajkovic, Eva Maria Mandelkow, Mikael Simons, Mikael Simons, Robert Weissert, Gilda Wright Araújo   +10 more
openaire   +6 more sources

Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis. [PDF]

, 2013
BackgroundTherapeutic strategies that induce effective neuroprotection and enhance intrinsic repair mechanisms are central goals for future treatment of multiple sclerosis (MS), as well as other diseases.
Hannsun, Gemmy, Hayardeny, Liat, Khalaj, Anna J, Martinez-Torres, Leonardo, Moore, Spencer, Patel, Rhusheet, Sasidhar, Manda, Tiwari-Woodruff, Seema K, Yoo, Timothy, Yoon, Jaehee   +9 more
core  

Characterization of the T cell receptor repertoire causing collagen arthritis in mice [PDF]

, 1993
Collagen type II-induced arthritis (CIA) is generated in susceptible rodent strains by intradermal injections of homologous or heterologous native type II collagen in complete Freund's adjuvant.
Hood, Leroy E., Kanagawa, Osami, Osman, Gamal-E, Toda, Masaaki   +3 more
core   +2 more sources

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source