Results 81 to 90 of about 5,529,456 (280)
A brief explanation of Kant's Enlightenment article [PDF]
, 2020 A presentation of Kant's idea for enlightenment process that was happening at that time. I try to be objective as it is needed to give a thorough explanation for what was the main subject in this process.
Millo, Florian
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Knowledge-based Transfer Learning Explanation [PDF]
, 2018 Machine learning explanation can significantly boost machine learning's application in decision making, but the usability of current methods is limited in human-centric explanation, especially for transfer learning, an important machine learning branch ...
Chen, Huajun +4 more
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The language of explanation dedicated to technical documents [PDF]
Sintagma, 2011 In this paper, we introduce a study of explanations as they appear in technical documents, in particular procedures where they are crucial. Our study is based on an extensive corpus analysis.
Sarah Bourse, Patrick Saint-Dizier
doaj
Explanation and discovery in aerodynamics [PDF]
, 2005 The purpose of this paper is to discuss and clarify the explanations commonly cited for the aerodynamic lift generated by a wing, and to then analyse, as a case study of engineering discovery, the aerodynamic revolutions which have taken place within ...
McCabe, Gordon
core +1 more source
Scientific Explanation and Moral Explanation* [PDF]
Noûs, 2011 AbstractMoral philosophers are, among other things, in the business of constructing moral theories. And moral theories are, among other things, supposed to explain moral phenomena. Consequently, one's views about the nature of moral explanation will influence the kinds of moral theories one is willing to countenance.
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Qualitative Theory and Chemical Explanation [PDF]
, 2002 Roald Hoffmann and other theorists claim that we we ought to use highly idealized chemical models (``qualitative models'') in order to increase our understanding of chemical phenomena, even though other models are available which make more highly ...
Weisberg, Michael
core
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source