Results 91 to 100 of about 27,541,156 (167)

The Arabidopsis thaliana F-box gene HAWAIIAN SKIRT is a new player in the microRNA pathway. [PDF]

PLoS ONE, 2017
In Arabidopsis, the F-box HAWAIIAN SKIRT (HWS) protein is important for organ growth. Loss of function of HWS exhibits pleiotropic phenotypes including sepal fusion.
Xuebin Zhang, Dasuni Jayaweera, Janny L Peters, Judit Szecsi, Mohammed Bendahmane, Jeremy A Roberts, Zinnia H González-Carranza   +6 more
doaj   +1 more source

RNAi‐mediated knockdown of exportin 1 negatively affected ovary development, survival and maize mosaic virus accumulation in its insect vector Peregrinus maidis

Insect molecular biology (Print)
Exportin 1 (XPO1) is the major karyopherin‐β nuclear receptor mediating the nuclear export of hundreds of proteins and some classes of RNA and regulates several critical processes in the cell, including cell‐cycle progression, transcription and ...
César A. D. Xavier, Clara Tyson, Leo M. Kerner, A. Whitfield   +3 more
semanticscholar   +1 more source

Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs

WIREs RNA, Volume 17, Issue 4, July/August 2026.
NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind, Samira K. Bell, Carol S. Lutz   +2 more
wiley   +1 more source

Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5

Nature Communications
Gene expression in response to environmental stimuli is dependent on nuclear localization of key signaling components, which can be tightly regulated by phosphorylation.
Ho Yee Joyce Fung, Sanraj R. Mittal, Ashley B. Niesman, Jenny Jiou, Binita Shakya, Takuya Yoshizawa, Ahmet E. Cansizoglu, Michael P. Rout, Yuh Min Chook   +8 more
doaj   +1 more source

Translocation Biosensors – Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

Sensors, 2009
Fluorescent protein biosensors are powerful cellular systems biology tools for dissecting the complexity of cellular processes with high spatial and temporal resolution. As regulated nucleo-cytoplasmic transport is crucial for the modulation of numerous (
Roland H. Stauber, Shirley K. Knauer, Jens Peter von Kries, Carolin Bier, Verena Fetz   +4 more
doaj   +1 more source

Karyopherin Dysfunction Is a Key Driver of Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Studies on the proteostasis network and aging have focused on protein synthesis, folding, and turnover. Here, emphasis on the spatial dimension in proteostasis is proposed by recognizing nucleocytoplasmic transport as an important player in aging. ABSTRACT Aging is often framed as the gradual erosion of proteostasis, driven by declining chaperone ...
Louis R. Lapierre
wiley   +1 more source

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Amyotrophic lateral sclerosis (ALS) involves widespread cortical pathology beyond the motor cortex. Human‐induced pluripotent stem cell‐derived neural organoids model cortical tissue in vitro and provide a physiologically relevant platform to study disease mechanisms in ALS.
Kristel N. Eigenhuis, Roberto Montoro Ferrer, R. Jeroen Pasterkamp   +2 more
wiley   +1 more source

Extranodal natural killer/T‐cell lymphoma: From fatal to curable

CA: A Cancer Journal for Clinicians, Volume 76, Issue 4, July/August 2026.
Abstract Extranodal natural killer (NK)/T‐cell lymphoma (ENKTCL) is one of the most aggressive non‐Hodgkin lymphomas characterized by NK‐cell or T‐cell origins, a geographic prevalence in Asian and South American populations, and Epstein–Barr virus (EBV) infection.
Jie Xiong, Yok‐Lam Kwong, Laurence de Leval, Shu‐Nan Qi, Choon Kiat Ong, Philippe Gaulard, Arnaud Jaccard, Steven M. Horwitz, Ye‐Xiong Li, Sai‐Juan Chen, Ritsuro Suzuki, Won Seog Kim, Wei‐Li Zhao   +12 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Nature Communications
Parental experiences can affect the phenotypic plasticity of offspring. In locusts, the population density that adults experience regulates the number and hatching synchrony of their eggs, contributing to locust outbreaks.
Ya′nan Zhu, Jing He, Jiawen Wang, Wei Guo, Hongran Liu, Zhuoran Song, Le Kang   +6 more
doaj   +1 more source