Results 91 to 100 of about 30,000,744 (172)

Influence of importin α/β and exportin 1 on equine herpesvirus type 1 (EHV-1) replication in primary murine neurons [PDF]

, 2013
Viruses replicating in the nucleus need to cross the nuclear membrane barrier during infection, therefore disruption of specific nuclear transport pathways is crucial for their replication cycle. In the present study we have investigated the influence of
Cymerys, J., Skwarska, J., Golke, A., Banbura, M W, Slonska, A.   +4 more
core  

XPO1 Inhibition enhances sensitivity to platinum-based chemotherapy in germinal-center B-cell-like-DLBCL cells

Hematology
Purpose: Platinum-based chemotherapy is considered as salvage therapy to relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients. However, treatment failure due to drug resistance occurs in some patients, particularly those with Exportin 1 ...
Qiongqiong Su, Xiaolei Wei, Yongqiang Wei, Ru Feng   +3 more
doaj   +1 more source

Mechanistic Insights from Structural Analyses of Ran-GTPase-Driven Nuclear Export of Proteins and RNAs [PDF]

, 2016
Understanding how macromolecules are rapidly exchanged between the nucleus and the cytoplasm through nuclear pore complexes is a fundamental problem in biology. Exportins are Ran-GTPase-dependent nuclear transport factors that belong to the karyopherin-β
Matsuura, Yoshiyuki
core   +1 more source

Ank1 and Ank6 each interact with importin β1 and exportin 1.

, 2018
Whole cell lysates of HeLa cells expressing Flag-tagged BAP, Ank1, Ank6, or Ank7 were incubated with Flag antibody-conjugated agarose beads to immunoprecipitate Flag-tagged proteins and their interacting proteins. Resulting Western blots were probed with
Haley E. Adcox (5180984), Sean M. Evans (2902031), Kyle G. Rodino (2902019), Jason A. Carlyon (690352)   +3 more
core   +1 more source

Xpo7 is a broad-spectrum exportin and a nuclear import receptor. [PDF]

, 2018
Exportins bind cargo molecules in a RanGTP-dependent manner inside nuclei and transport them through nuclear pores to the cytoplasm. CRM1/Xpo1 is the best-characterized exportin because specific inhibitors such as leptomycin B allow straightforward cargo
Karaca, Samir, Henning Urlaub, Seibel, K., Aksu, Metin, Aksu, M., Urlaub, Henning, Kappert, Christin, Katharina Seibel, Samir Karaca, Christin Kappert, Bohnsack, Markus T., Pleiner, T., Dehne, H., Seibel, Katharina, Bohnsack, M., Markus T. Bohnsack, Heinz-Jürgen Dehne, Görlich, D., Pleiner, Tino, Tino Pleiner, Kappert, C., Urlaub, H., Dirk Görlich, Metin Aksu, Görlich, Dirk, Dehne, Heinz-Jürgen, Karaca, S.   +26 more
core   +1 more source

Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder

, 2013
Background and Objectives MicroRNAs (miRNAs) are aberrantly expressed in cancers. Dicer, Drosha, and Exportin 5 are essential for miRNA processing.
Cai, Zhiming, Liu, Yuchen, Gui, Yaoting, Han, Yonghua   +3 more
core   +1 more source

Lower dose and weekly schedules of selinexor in multiple myeloma - updated evidence on safety and efficacy

Frontiers in Oncology
BackgroundSelinexor, a first-in-class, oral exportin-1 inhibitor, showed activity in penta-refractory multiple myeloma (MM) in early trial exploration; however, the side-effect profile of twice-weekly dosing led to hesitant incorporation into widespread ...
Muhamed Baljevic, Gary Schiller, Tomer M. Mark, Dane R. Van Domelen, Cristina Gasparetto   +4 more
doaj   +1 more source

Targeting Exportin-1 to Inhibit HTLV-1 Infection

, 2020
Human T-cell Leukemia Virus Type-1 (HTLV-1) is a complex human retrovirus that infects around 20 million people globally. Transmission of this retrovirus occurs by sexual intercourse, contaminated blood, and from mother to child by breastfeeding.
Norton, Christopher, NC DOCKS at East Carolina University   +1 more
core   +2 more sources

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

Molecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar, T.G. Thakurta, M.J. Silvestrini, J.R. Johnson, R.A. Reenan, L.R. Lapierre   +5 more
doaj   +1 more source

Binding of Carbonic Anhydrase IX to 45S rDNA Genes Is Prevented by Exportin-1 in Hypoxic Cells

, 2015
Carbonic anhydrase IX (CA IX) is a surrogate marker of hypoxia, involved in survival and pH regulation in hypoxic cells. We have recently characterized its interactome, describing a set of proteins interacting with CA IX, mainly in hypoxic cells ...
Santoriello, Margherita, Luca Alfredo Paolella, Monteleone, Francesca, Jean-Yves Winum, Mariangela Sabatella, Nicola Zambrano, Crifò, Bianca, Boffo, Francesca Ludovica, Francesca Monteleone, Margherita Santoriello, Vitale, Monica, Emanuele Sasso, Giuseppina Minopoli, Winum, Jean-Yves, Francesca Boffo, Paolella, Luca Alfredo, Minopoli, Giuseppina, Sasso, Emanuele, Daniela Sarnataro, Sarnataro, Daniela, Zambrano, Nicola, Sabatella, Mariangela, Garbi, Corrado, Corrado Garbi, Monica Vitale, Bianca Crifò   +25 more
core   +1 more source