Results 101 to 110 of about 30,000,744 (172)

Integrative multiomics analysis identifies molecular subtypes and potential targets of hepatocellular carcinoma

Clinical and Translational Medicine
Background The liver is anatomically divided into eight segments based on the distribution of Glisson's triad. However, the molecular mechanisms underlying each segment and its association with hepatocellular carcinoma (HCC) heterogeneity are not well ...
Shuai Yang, Lu Zheng, Lingling Li, Jiangang Zhang, Jingchun Wang, Huakan Zhao, Yu Chen, Xudong Liu, Hui Gan, Junying Chen, Mei Yan, Chuanyin He, Kai Li, Chen Ding, Yongsheng Li   +14 more
doaj   +1 more source

Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression

Cell & Bioscience
Background The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates with subcellular localisation and
Morgan L Marshall, Kim YC Fung, David A Jans, Kylie M Wagstaff   +3 more
doaj   +1 more source

Novel—and Not So Novel—Inhibitors of the Multifunctional CRM1 Protein

Oncology Reviews
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex.
Waitman K. Aumann, Waitman K. Aumann, Rafi Kazi, Amanda M. Harrington, Daniel S. Wechsler, Daniel S. Wechsler   +5 more
doaj   +1 more source

Identification of the Ank1 and Ank6 domains that are essential for the ability to co-immunoprecipitate p65, importin β1, and exportin 1.

, 2018
Whole cell lysates of HeLa cells expressing the indicated Flag-tagged proteins were incubated with Flag antibody-conjugated agarose beads to immunoprecipitate Flag-tagged proteins and their interacting proteins.
Haley E. Adcox (5180984), Sean M. Evans (2902031), Kyle G. Rodino (2902019), Jason A. Carlyon (690352)   +3 more
core   +1 more source

XPO1-dependent nuclear export regulates NS3 localization and promotes DENV-2 replication through mitochondrial remodeling and interferon suppression

Nucleus
Nucleocytoplasmic transport is essential for cellular homeostasis and is frequently exploited by viruses during infection. Although dengue virus (DENV) non-structural protein 3 (NS3) undergoes nuclear trafficking, the role of nuclear export pathways in ...
Selvin Noé Palacios-Rápalo, Jonathan Hernández-Castillo, Luis Adrián De Jesús-González, Daniel Talamas-Lara, Carlos Daniel Cordero-Rivera, Bulmaro Cisneros-Vega, Jose Manuel Reyes-Ruiz, Rosa María del Ángel   +7 more
doaj   +1 more source

세포노화 과정 중 G-actin의 핵 내 축적: Exportin 6와 Ran-GTP의 발현 및 분포변화

, 2008
Actin is a highly conserved, ubiquitous cytoskeletal protein, which contains two leucine-rich nuclear export signal (NES) sequences in the middle of the molecule.
박, 수현
core   +1 more source

Exportin-1 [PDF]

, 2020
openaire   +1 more source

Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα-NF-κB p65 Complex. [PDF]

Front Pharmacol, 2022
Chen J, Song D, Xu Y, Wu L, Tang L, Su Y, Xie X, Zhao J, Xu J, Liu Q.   +9 more
europepmc   +1 more source

Anticancer effects of an XPO1 inhibitor (selinexor) with sotorasib following omeprazole preconditioning in KRAS G12C-mutant non-small cell lung cancer cells in vitro and in a mouse tumor xenograft

Neoplasia: An International Journal for Oncology Research
Background: KRAS G12C-mutant advanced non-small cell lung cancer (NSCLC) is currently treated with KRAS G12C covalent inhibitors, such as sotorasib, or RAS (ON) G12-selective inhibitors; however, response rates and progression-free survival remain ...
Jèssica González, Xueting Cai, Wenjing Diao, Gaël Roué, Kevin València-Clua, Daniel Olmo-González, María González-Cao, Anisha Jain, Eloisa Jantus-Lewintre, Ana Giménez-Capitán, Miguel Angel Molina-Vila, Jordi Codony-Servat, Peng Cao, Rafael Rosell   +13 more
doaj   +1 more source

CD47 interactions with exportin-1 limit the targeting of m⁷G-modified RNAs to extracellular vesicles. [PDF]

J Cell Commun Signal, 2022
Kaur S, Saldana AC, Elkahloun AG, Petersen JD, Arakelyan A, Singh SP, Jenkins LM, Kuo B, Reginauld B, Jordan DG, Tran AD, Wu W, Zimmerberg J, Margolis L, Roberts DD.   +14 more
europepmc   +1 more source