Results 101 to 110 of about 14,810 (190)

Exercise and Skeletal Muscle‐Derived Extracellular Vesicles: Their Cargo, Release, and Role in Metabolic Regulation

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT The health benefits of exercise are well established in the prevention and management of metabolic disorders such as obesity and diabetes. Emerging evidence indicates that extracellular vesicles (EVs) may contribute to the beneficial effects of exercise.
Jeremy Boulestreau, Scott K. Ferguson, Luke Nelson, Noemi Polgar   +3 more
wiley   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, Volume 13, Issue 20, 9 April 2026.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing [PDF]

, 2013
Nuclear mRNA export is a highly complex and regulated process in cells. Cellular transcripts must undergo successful maturation processes, including splicing, 5'-, and 3'-end processing, which are essential for assembly of an export competent ...
Adrian Whitehouse, Ambroziak, Belinda Baquero-Perez, Bello, Bray, Brennan, Brian Jackson, Chang, Folco, Goodwin, Hakata, Hautbergue, Hiriart, Jackson, Kang, Kieff, Kudo, Massimelli, Moore, Nakano, Penn, Semmes, Sophie Schumann, Soulier, Staskus   +24 more
core   +3 more sources

Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5

Nature Communications
Gene expression in response to environmental stimuli is dependent on nuclear localization of key signaling components, which can be tightly regulated by phosphorylation.
Ho Yee Joyce Fung, Sanraj R. Mittal, Ashley B. Niesman, Jenny Jiou, Binita Shakya, Takuya Yoshizawa, Ahmet E. Cansizoglu, Michael P. Rout, Yuh Min Chook   +8 more
doaj   +1 more source

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, Volume 13, Issue 23, 23 April 2026.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source

Inside out: the role of nucleocytoplasmic transport in ALS and FTLD [PDF]

, 2016
Neurodegenerative diseases are characterized by the presence of protein inclusions with a different protein content depending on the type of disease. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are no exceptions to ...
Steven Boeynaems, Elke Bogaert, Philip Van Damme, Ludo Van Den Bosch   +3 more
core   +7 more sources

2026 Update on the Management of Diffuse Large B‐Cell Lymphoma

American Journal of Hematology, Volume 101, Issue 4, Page 832-863, April 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong, Emily B. Tomasulo, Stefan K. Barta   +2 more
wiley   +1 more source

Components and regulation of nuclear transport processes [PDF]

, 2015
The spatial separation of DNA replication and gene transcription in the nucleus and protein translation in the cytoplasm is a uniform principle of eukaryotic cells. This compartmentalization imposes a requirement for a transport network of macromolecules
Alefantis, Argentaro, Arnaoutov, Arts, Arts, Askjaer, Bardina, Bayliss, Beals, Beck, Bednenko, Beg, Belov, Bernad, Bischoff, Bogerd, Bohnsack, Bohnsack, Bono, Bourne, Brickner, Bui, Bunn, Calado, Callan, Caly, Capelson, Carmody, Castello, Cautain, Chen, Chook, Ciufo, Conti, Conti, Cook, Cour, Craig, Cronshaw, Debler, Devos, Dingwall, Dong, Dong, Dorfman, Englmeier, Erickson, Erkmann, Ertel, Feng, Ferrigno, Field, Fineberg, Fischer, Fontoura, Fornerod, Fornerod, Frey, Frey, Fried, Frieman, Fu, Fu, Fukuda, Fukuda, Gadal, Ghildyal, Goldfarb, Gontan, Gorlich, Gorlich, Grespin, Grossman, Gustin, Gustin, Guttler, Hall, Harel, Hellmuth, Henderson, Hill, Hill, Ho, Hoelz, Holaska, Hopper, Huang, Huber, Hubner, Hung, Hussain, Hutten, Hutten, Isgro, Izaurralde, Kalab, Kalderon, Kalderon, Katahira, Kehlenbach, Kehlenbach, Kobbe, Kohler, Komeili, Kopecky-Bromberg, Kosugi, Kosugi, Kosugi, Krull, Kunzler, Kunzler, Kurisaki, Kutay, Kutay, Lam, Lange, Lange, Lange, Lee, Lee, Lidsky, Lim, Lim, Lim, Lim, Lindsay, Long, Luna, Lund, Macara, Maimon, Makkerh, Malik, Malim, Malim, Malim, Malim, Marfori, Mateo, Maurer, Melchior, Melcák, Mingot, Mingot, Mitchell, Monecke, Moore, Moore, Mor, Mosammaparast, Murdoch, Nemergut, Neumann, Ohno, Ossareh-Nazari, Paraskeva, Park, Peters, Porter, Prieto, Ren, Rexach, Ribbeck, Richards, Riviere, Rodriguez, Rodriguez-Navarro, Rouquette, Rout, Rout, Sarma, Schwartz, Shabman, Shin, Shuai, Siddiqui, Solsbacher, Sorokin, Speese, Stade, Stommel, Strambio-De-Castillia, Suel, Therizols, Thomas, Traenckner, Tran, Truant, Turner, Turner, Vosse, Wagstaff, Walther, Watters, Weighardt, Wen, Wen, Wente, Wild, Xu, Xu, Yang, Yi, Zanella   +203 more
core   +1 more source

Chromosome‐scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1

Insect Science, Volume 33, Issue 2, Page 640-664, April 2026.
Anastrepha fraterculus sp. 1 is a major fruit fly pest in Argentina, currently controlled through chemical treatments and traps. This study aims to enhance the genomic understanding of this species to support the development of sterile insect technique as well as the use of innovative technologies.
Máximo Rivarola, Claudia A. Conte, Pierre Berube, Shu‐Huang Chen, M. Cecilia Giardini, Alejandra C. Scannapieco, Fabián H. Milla, María C. Soria, Romina M. Russo, Juan P. Wulff, Haig H. Djambazian, Rolando R. Pomar, Alfred M. Handler, Kostas Bourtzis, Ioannis Ragoussis, Silvia B. Lanzavecchia   +15 more
wiley   +1 more source

Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response. [PDF]

, 2018
In Trypanosoma brucei and related kinetoplastid parasites, transcription of protein coding genes is largely unregulated. Rather, mRNA binding proteins, which impact processes such as transcript stability and translation efficiency, are the predominant ...
Debler, Erik W., Kafková, Lucie, Paul, Kimberly S., Pazzo, Kyle L., Qu, Jun, Read, Laurie K., Smith, Kyle P., Tu, Chengjian   +7 more
core   +2 more sources