Results 101 to 110 of about 27,541,156 (167)
HematologyPurpose: Platinum-based chemotherapy is considered as salvage therapy to relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients. However, treatment failure due to drug resistance occurs in some patients, particularly those with Exportin 1 ...
Qiongqiong Su +3 more
doaj +1 more source
Retreatment with talquetamab and pomalidomide in triple‐class–BCMA–GPRC5D refractory myeloma
British Journal of Haematology, Volume 209, Issue 1, Page 320-323, July 2026.
Kian J. Rahbari +4 more
wiley +1 more source
Neurobiology of Disease, 2013 Huntington's disease is characterized by the formation of protein aggregates, which can be degraded by macroautophagy. Here, we studied protein levels and intracellular distribution of p62 and NBR1, two macroautophagy cargo receptors, during disease ...
Laura Rué +5 more
doaj +1 more source
Frontiers in OncologyBackgroundSelinexor, a first-in-class, oral exportin-1 inhibitor, showed activity in penta-refractory multiple myeloma (MM) in early trial exploration; however, the side-effect profile of twice-weekly dosing led to hesitant incorporation into widespread ...
Muhamed Baljevic +4 more
doaj +1 more source
Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging
Molecular & Cellular Oncology, 2018 Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar +5 more
doaj +1 more source
Clinical and Translational MedicineBackground The liver is anatomically divided into eight segments based on the distribution of Glisson's triad. However, the molecular mechanisms underlying each segment and its association with hepatocellular carcinoma (HCC) heterogeneity are not well ...
Shuai Yang +14 more
doaj +1 more source
Cell & BioscienceBackground The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here, we show that expression of alpha-enolase correlates with subcellular localisation and
Morgan L Marshall +3 more
doaj +1 more source
Novel—and Not So Novel—Inhibitors of the Multifunctional CRM1 Protein
Oncology ReviewsChromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex.
Waitman K. Aumann +5 more
doaj +1 more source
NucleusNucleocytoplasmic transport is essential for cellular homeostasis and is frequently exploited by viruses during infection. Although dengue virus (DENV) non-structural protein 3 (NS3) undergoes nuclear trafficking, the role of nuclear export pathways in ...
Selvin Noé Palacios-Rápalo +7 more
doaj +1 more source