Results 151 to 160 of about 30,000,744 (172)

EXPORTIN 1 INHIBITION ATTENUATES NUCLEAR FACTOR-κB-DEPENDENT GENE EXPRESSION

Shock, 2008
Activation of nuclear factor (NF)-kappaB is mediated by signal-induced phosphorylation of IkappaBalpha, subsequent IkappaBalpha degradation, and then translocation of unbound NF-kappaB to the nucleus. Termination of gene expression occurs when IkappaBalpha binds NF-kappaB subunits (Rel A) in the nucleus.
Mark D, Walsh, Christine R, Hamiel, Anirban, Banerjee, Aaron M, Cheng, Guillermo, Escobar, Robert C, McIntyre   +5 more
openaire   +2 more sources

SINE compounds activate exportin-1 degradation via an allosteric mechanism

The nuclear export receptor exportin 1 (XPO1/CRM1) is often overexpressed in cancer cells, leading to the mislocalization of numerous cancer-related protein cargoes 1,2 . Selinexor, a covalent XPO1 inhibitor, and other Selective Inhibitor of Nuclear Export (SINEs) restore proper nuclear ...
Casey Elizabeth Wing, Ho Yee Joyce Fung, Bert Kwanten, Tolga Cagatay, Ashley B. Niesman, Maarten Jacquemyn, Mehdi Gharghabi, Brecht Permentier, Binita Shakya, Rhituparna Nandi, Joseph M. Ready, Trinayan Kashyap, Sharon Shacham, Yosef Landesman, Rosa Lapalombella, Dirk Daelemans, Yuh Min Chook   +16 more
openaire   +2 more sources

Identifying novel inhibitors targeting Exportin-1 for the potential treatment of COVID-19

Archives of Microbiology
The nuclear export protein 1 (XPO1) mediates the nucleocytoplasmic transport of proteins and ribonucleic acids (RNAs) and plays a prominent role in maintaining cellular homeostasis. XPO1 has emerged as a promising therapeutic approach to interfere with the lifecycle of many viruses.
Tanuj, Sharma, Tanmoy, Mondal, Sajid, Khan, Marianela Patzi, Churqui, Kristina, Nyström, Ketan, Thombare, Mohammad Hassan, Baig, Jae-June, Dong   +7 more
openaire   +2 more sources

Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation

Nature Chemical Biology
Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such as centrosome duplication. Small molecules targeting XPO1 induce cytotoxicity, and selinexor was approved by the Food and Drug Administration in 2019 as a cancer chemotherapy for relapsed multiple
Yi Fan Chen, Maryam Ghazala, Ryan M. Friedrich, Brittany A. Cordova, Frederick N. Petroze, Ramya Srinivasan, Kevin C. Allan, David F. Yan, Joel L. Sax, Kelley Carr, Suzanne L. Tomchuck, Yuriy Fedorov, Alex Y. Huang, Amar B. Desai, Drew J. Adams   +14 more
openaire   +2 more sources

Selinexor. Exportin-1 (XPO1) inhibitor, Oncolytic

Drugs of the Future, 2014
null Riaz, W., null Burke, N., null Mahipal, A.   +2 more
openaire   +1 more source

Key role of exportin 6 in exosome-mediated viral transmission from insect vectors to plants

Proceedings of the National Academy of Sciences of the United States of America, 2022
Feng Cui, Qiong Li
exaly  

INHIBITION OF EXPORTIN-1 DISRUPTS MYD88 DEPENDENT SIGNALING.

Shock, 2004
M. D. Walsh, K. A. Barsness, J. Y. Cha, J. H. Clarke, A. Banerjee, R. C. McIntyre   +5 more
openaire   +1 more source

CD47 interactions with exportin-1 limit the targeting of m7G-modified RNAs to extracellular vesicles

Journal of Cell Communication and Signaling, 2021
Joshua Zimmerberg, Abdel G Elkahloun, David D Roberts   +2 more
exaly  

Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis

Proceedings of the National Academy of Sciences of the United States of America, 2016
Young-Kook Kim, Vic Narry Kim, Boseon Kim   +2 more
exaly  

The role of exportin‐t in selective nuclear export of mature tRNAs

EMBO Journal, 1998
Pascale Romby, Iain W Mattaj, Bernard Ehresmann   +2 more
exaly