Results 151 to 160 of about 14,810 (190)

Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death. [PDF]

Cell Cycle, 2018
Marcus JM, Burke RT, Doak AE, Park S, Orth JD.   +4 more
europepmc   +1 more source

Iwr1 directs RNA polymerase II nuclear import [PDF]

, 2011
Czeko, Elmar
core  

Phytophthora capsici carries and differentially expresses genes for the RNA interference pathway. [PDF]

PLoS One
Sevillano-Serrano J, Rojas-Rojas FU, Méndez-Bravo A, Calderón-Cortés N, Shimada-Beltrán H, Vega-Arreguín J.   +5 more
europepmc   +1 more source

RNA export through the nuclear pore complex: pathways, mechanisms, and imaging strategies. [PDF]

RNA Biol
Fu D, Yu W, Zhang F, Rush C, Tingey M, Yang W.   +5 more
europepmc   +1 more source

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor [PDF]

Cell, 1997
Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not well understood. Using a novel protein export assay in S. cerevisiae, we identify CRM1 as an essential mediator of nuclear protein export in yeast.
Karsten Weis
exaly   +3 more sources

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Ratjadones inhibit nuclear export by blocking CRM1/exportin 1

Experimental Cell Research, 2003
In addition to previously isolated ratjadone A we describe three new members of this family, ratjadones B, C, and D, from another strain of the myxobacterium Sorangium cellulosum. We have investigated the properties of these ratjadones with respect to their activity on mammalian cell lines.
Søren Lykke-Andersen, Jørgen Kjems
exaly   +4 more sources

Exportin 1‐independent nuclear export of GAPDH

Cell Biology International, 2003
AbstractGlyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) is a key enzyme of the glycolytic pathway. Recent studies have demonstrated an additional role in apoptosis: GAPDH is targeted to the nucleus during apoptotic signalling. This nuclear transport has also been observed in serum‐depleted cells, but it is reversible in fibroblasts, in contrast to ...
Hans-Dirk, Schmitz, Christine, Dutiné, Jürgen, Bereiter-Hahn   +2 more
openaire   +2 more sources

Small-Molecule Antagonist Targeting Exportin-1 via Rational Structure-Based Discovery

Journal of Medicinal Chemistry, 2020
Exportin-1 (also named as CRM1) plays a prominent role in autoimmune disorders and has emerged as a potential therapeutic target for colitis. Here we report on the rational structure-based discovery of a small-molecule antagonist of exportin-1, LFS-829, with low-range nanomolar activities.
Xibao Tian, Jiali Gao, Meishuo Liu, Yuqin Lei, Fangjun Wang, Jin Chen, Peng Chu, Jiujiao Gao, Feida Long, Minzhi Liang, Xiangyu Long, Huiying Chu, Cuixia Liu, Xueliang Li, Qingxiang Sun, Guohui Li, Yongliang Yang   +16 more
openaire   +2 more sources