Results 131 to 140 of about 27,541,156 (167)

Exportin-1 is required for the maintenance of the planarian epidermal lineage

International Journal of Biological Macromolecules, 2019
Nucleocytoplasmic transport is essential for normal cellular function that mediates cargo transport from the cytoplasm to the nucleus. However, the mechanisms of nucleocytoplasmic transport that integrate stem cell development remain largely unknown. Since it has a large population of stem cells, the planarian flatworm is an ideal system for the study ...
, Jiaqian Liu
exaly   +3 more sources

Exportin-1 and epigenetic modifications interaction: more than nuclear transport

Human Cell
Exportin-1 (XPO1) is fundamental in the regulation of nuclear-to-cytoplasm transportation. XPO1 has the ability to transport hundreds of proteins and several different types of mRNAs responsible for proper cellular biology. Deregulation of the XPO1 transportation system aberrantly translocates transcription factors promoting the pathogenesis of ...
L. Benetatos, E. Hatzimichael, Eleni Kapsali   +2 more
semanticscholar   +3 more sources

Ratjadones inhibit nuclear export by blocking CRM1/exportin 1

Experimental Cell Research, 2003
In addition to previously isolated ratjadone A we describe three new members of this family, ratjadones B, C, and D, from another strain of the myxobacterium Sorangium cellulosum. We have investigated the properties of these ratjadones with respect to their activity on mammalian cell lines.
Søren Lykke-Andersen, Florenz Sasse, Jorgen Kjems   +2 more
exaly   +4 more sources

Exportin 1‐independent nuclear export of GAPDH

Cell Biology International, 2003
AbstractGlyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) is a key enzyme of the glycolytic pathway. Recent studies have demonstrated an additional role in apoptosis: GAPDH is targeted to the nucleus during apoptotic signalling. This nuclear transport has also been observed in serum‐depleted cells, but it is reversible in fibroblasts, in contrast to ...
Hans-Dirk, Schmitz, Christine, Dutiné, Jürgen, Bereiter-Hahn   +2 more
openaire   +2 more sources

Safety of selinexor as the only exportin 1 (XPO1) inhibitor so far: a post-marketing study based on the world Health Organization pharmacovigilance database (Vigibase)

Expert Opinion on Drug Safety, 2023
Background Exportin 1 (XPO1) inhibitors are being developed as a new agent for anti-cancer therapies. This study aimed to broadly portray the adverse event (AE) profile of selinexor, an XPO1 inhibitor, in actual clinical practice.
Chenxin Chen, Xiaoyong Miao, Xiao-jing Guo, Jinfang Xu, Jizhou Liang, Yi Zheng, L. Chi, Xiao Chen, Lianhui Wei, Hewei Zhang, X. Ye, Jia He   +11 more
semanticscholar   +1 more source

Exportin-1 is critical for cell proliferation and survival in adult T cell leukemia

Investigational New Drugs, 2022
Since treatment options for adult T cell leukemia (ATL) associated with human T cell leukemia virus type 1 (HTLV-1) fail to obtain long-term response, novel therapies targeting ATL-dysregulated pathways are necessary. Dysregulated nuclear import and export machinery is common in malignancies. This study aimed to investigate the potential of exportin-1 (
Chie Ishikawa, N. Mori
semanticscholar   +3 more sources

Abstract 3858: Exploring Exportin-1 as a therapeutic vulnerability in squamous cell carcinoma

Cancer Research, 2023
Introduction: Squamous cell carcinomas (LUSCs) account for 25-30% cases of non-small cell lung cancers, making them the second most common histology of lung cancer after adenocarcinomas.
V. Durani, Rebecca Caeser, C. Rudin, Á. Quintanal-Villalonga, Harsha Sridhar, P. Manoj, Sam E. Tischfield, M. Asher, U. Bhanot, J. Egger, N. Socci, Nisargbhai S. Shah, E. de Stanchina, N. Rekhtman   +13 more
semanticscholar   +1 more source

Abstract 6188: Exportin 1 inhibition synergizes with lurbinectedin by altering the response to DNA damage in neuroendocrine lung tumors

Cancer Research, 2023
Background: Neuroendocrine lung cancer carcinomas (Lung NECs), which include large cell neuroendocrine carcinomas (LCNECs) and small cell lung cancer (SCLC) tumors, are particularly aggressive lung neoplasms with limited clinical therapeutic options ...
Esther Redin Resano, C. Rudin, Á. Quintanal-Villalonga   +2 more
semanticscholar   +1 more source

Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation

Nature Chemical Biology
Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such as centrosome duplication. Small molecules targeting XPO1 induce cytotoxicity, and selinexor was approved by the Food and Drug Administration in 2019 as a cancer chemotherapy for relapsed multiple
Yi Fan Chen, Maryam Ghazala, Ryan M. Friedrich, Brittany A Cordova, Frederick N Petroze, Ramya Srinivasan, Kevin C. Allan, David F Yan, J. Sax, Kelley Carr, Suzanne L. Tomchuck, Yuriy Fedorov, Alex Y. Huang, Amar B Desai, Drew J. Adams   +14 more
semanticscholar   +3 more sources

Expression of exportin 1 (XPO1/CRM1) in pancreatic adenocarcinoma.

Journal of Clinical Oncology, 2017
327 Background: Exportin 1 (XPO1/CRM1) is a nuclear export chaperone that mediates the nuclear export of several proteins that are essential to growth regulation and tumor suppression. It was found to be overexpressed in several types of human malignancies and overexpression was found to be associated with poor prognosis.
David M Saulino, Pamela S Younes, Jennifer M Biley, Mamoun Younes   +3 more
openaire   +1 more source