Results 141 to 150 of about 30,000,744 (172)

Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1 [PDF]

Cell Reports, 2021
Aberrant expression of nuclear transporters and deregulated subcellular localization of their cargo proteins are emerging as drivers and therapeutic targets of cancer.
Cuige Zhu, Jason M. Held, Eugene M Oltz
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Exportin 1‐independent nuclear export of GAPDH

Cell Biology International, 2003
AbstractGlyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) is a key enzyme of the glycolytic pathway. Recent studies have demonstrated an additional role in apoptosis: GAPDH is targeted to the nucleus during apoptotic signalling. This nuclear transport has also been observed in serum‐depleted cells, but it is reversible in fibroblasts, in contrast to ...
Hans-Dirk, Schmitz, Christine, Dutiné, Jürgen, Bereiter-Hahn   +2 more
openaire   +2 more sources

Targeting Exportin 1 as treatment for cutaneous squamous cell carcinoma.

Journal of Clinical Oncology, 2023
e21564 Background: Cutaneous squamous cell carcinomas (cSCC) are among the most frequent solid cancers in humans and in the U.S., cSCC cases are increasing. Molecular mechanisms transitioning premalignant lesions to cancer are not well characterized. As a result, targeted therapies need to be identified to treat these lesions.
Ricky Rana, Laura A. Hansen
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Exportin-1 is critical for cell proliferation and survival in adult T cell leukemia

Investigational New Drugs, 2022
Since treatment options for adult T cell leukemia (ATL) associated with human T cell leukemia virus type 1 (HTLV-1) fail to obtain long-term response, novel therapies targeting ATL-dysregulated pathways are necessary. Dysregulated nuclear import and export machinery is common in malignancies. This study aimed to investigate the potential of exportin-1 (
Chie, Ishikawa, Naoki, Mori
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Expression of exportin 1 (XPO1/CRM1) in pancreatic adenocarcinoma.

Journal of Clinical Oncology, 2017
327 Background: Exportin 1 (XPO1/CRM1) is a nuclear export chaperone that mediates the nuclear export of several proteins that are essential to growth regulation and tumor suppression. It was found to be overexpressed in several types of human malignancies and overexpression was found to be associated with poor prognosis.
David M Saulino, Pamela S Younes, Jennifer M Biley, Mamoun Younes   +3 more
openaire   +1 more source

Exportin-1 (XPO1, CRM1) inhibitors for the management of viral infection

Drugs of the Future, 2021
A therapeutic gap exists between new emerging infectious diseases and effective treatments. Targeting host factors involved in the replication strategies of evolutionarily diverse viruses may bridge this gap. Exportin-1 (XPO1, also termed chromosome region maintenance 1 [CRM1]) is a cellular nuclear export receptor for cellular and viral protein and ...
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Exploring the exportin-1 inhibitors for COVID-19 and anticancer treatment

Journal of Biomolecular Structure and Dynamics
Nuclear export protein 1, also known as XPO1, plays a crucial role in cellular homeostasis and assists in the nucleocytoplasmic transfer of ribonucleic acids (RNAs) and proteins. In addition, this nuclear export receptor is essential for the export of a variety of cargo molecules, such as proteins implicated in the immune response, tumor suppression ...
Tanuj, Sharma, Tanmoy, Mondal, Venu Venkatarame Gowda, Saralamma, Md Imtaiyaz, Hassan, Chang Joong, Kim, Marianela Patzi, Churqui, Kristina, Nyström, Ketan, Thombare, Mohammad Hassan, Baig, Jae-June, Dong   +9 more
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Inhibition of Exportin-1 inhibits endothelial cell ICAM expression

Journal of the American College of Surgeons, 2004
Abstract Introduction: Regulation of the export of adaptor proteins that reside in the nucleus may modulate signal transduction. MyD88 is the principal adaptor protein for Toll/IL-1 receptor signaling. We have observed that MyD88 is a predominantly nuclear protein in murine macrophages.
Mark D. Walsh, Anirban Banerjee, Christine Hamiel, Katherine Barsness, Robert McIntyre   +4 more
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Exportin-1 and epigenetic modifications interaction: more than nuclear transport

Human Cell
Exportin-1 (XPO1) is fundamental in the regulation of nuclear-to-cytoplasm transportation. XPO1 has the ability to transport hundreds of proteins and several different types of mRNAs responsible for proper cellular biology. Deregulation of the XPO1 transportation system aberrantly translocates transcription factors promoting the pathogenesis of ...
Leonidas Benetatos, Eleftheria Hatzimichael, Eleni Kapsali   +2 more
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SINE compounds activate exportin 1 degradation through an allosteric mechanism

Nature Chemical Biology
Overexpression of exportin 1 (XPO1/CRM1) in cancer cells mislocalizes numerous cancer-related nuclear export cargoes. Covalent selective inhibitors of nuclear export (SINEs), including the cancer drug selinexor, restore proper nuclear localization by blocking XPO1-cargo interaction.
Casey E. Wing, Ho Yee Joyce Fung, Bert Kwanten, Tolga Cagatay, Ashley B. Niesman, Maarten Jacquemyn, Mehdi Gharghabi, Brecht Permentier, Binita Shakya, Rhituparna Nandi, Joseph M. Ready, Trinayan Kashyap, Sharon Shacham, Yosef Landesman, Rosa Lapalombella, Dirk Daelemans, Yuh Min Chook   +16 more
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