Results 121 to 130 of about 27,541,156 (167)

Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells. [PDF]

Oncotarget, 2017
Burke RT, Marcus JM, Orth JD.
europepmc   +1 more source

The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors. [PDF]

Mol Cancer Ther, 2017
Farren MR, Hennessey RC, Shakya R, Elnaggar O, Young G, Kendra K, Landesman Y, Elloul S, Crochiere M, Klebanov B, Kashyap T, Burd CE, Lesinski GB.   +12 more
europepmc   +1 more source

Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1. [PDF]

Oncotarget, 2017
Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y.   +13 more
europepmc   +1 more source

Chromosome Maintenance Region 1 (CRM1, also called exportin 1) [PDF]

, 2008
openaire   +1 more source

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Targeting Exportin 1 as treatment for cutaneous squamous cell carcinoma.

Journal of Clinical Oncology, 2023
e21564 Background: Cutaneous squamous cell carcinomas (cSCC) are among the most frequent solid cancers in humans and in the U.S., cSCC cases are increasing. Molecular mechanisms transitioning premalignant lesions to cancer are not well characterized.
Ricky Rana, L. Hansen
semanticscholar   +2 more sources

Exploring the exportin-1 inhibitors for COVID-19 and anticancer treatment

Journal of Biomolecular Structure and Dynamics
Nuclear export protein 1, also known as XPO1, plays a crucial role in cellular homeostasis and assists in the nucleocytoplasmic transfer of ribonucleic acids (RNAs) and proteins.
Tanuj Sharma, Tanmoy Mondal, Venu Venkatarame Gowda Saralamma, M. Hassan, C. Kim, Marianela Patzi Churqui, Kristina Nyström, Ketan Thombare, Mohammad Hassan Baig, Jae-June Dong   +9 more
semanticscholar   +3 more sources

SINE compounds activate exportin 1 degradation through an allosteric mechanism

Nature Chemical Biology
Overexpression of exportin 1 (XPO1/CRM1) in cancer cells mislocalizes numerous cancer-related nuclear export cargoes. Covalent selective inhibitors of nuclear export (SINEs), including the cancer drug selinexor, restore proper nuclear localization by blocking XPO1-cargo interaction.
Casey E. Wing, H. Fung, B. Kwanten, Tolga Cagatay, Ashley B. Niesman, M. Jacquemyn, Mehdi Gharghabi, Brecht Permentier, Binita Shakya, Rhituparna Nandi, Joseph A. Ready, T. Kashyap, S. Shacham, Y. Landesman, R. Lapalombella, D. Daelemans, Y. Chook   +16 more
semanticscholar   +3 more sources