Results 101 to 110 of about 17,437,503 (278)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Effect of Using Hand-Weights on Performance in the Standing Long Jump [PDF]

, 2012
Previous standing long jump studies have shown that jumping with hand weights can significantly increase jumping performance. The purpose of this study was to investigate the mechanisms that enable performance improvement in the standing long jump when ...
Austin Filush, Filush, Austin
core  

Multilevel Structural Equation Models predicting state extra-role performance from state eudaimonic well-being.

, 2019
Multilevel Structural Equation Models predicting state extra-role performance from state eudaimonic well-being.
Małgorzata W. Kożusznik (6616355), Aida Soriano (6380762), José M. Peiró (6380756)   +2 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Are women more likely to engage in extra green behaviors in the workplace? Gender differences in the spillover effect from employee in-role to extra-role green behavior

Frontiers in Psychology
IntroductionWith the growing importance of green development, organizational research pointed that employee green behavior is an important micro foundation to addressing the environmental challenge.
Xinnan Wang, Jiafei Jin, Jialiang Xu, Mehedi Hasan Khan   +3 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Extra hole threshold in HfO2 ferroelectric phase stabilization

Communications Physics
Understanding ferroelectric phase stability in hafnium-based oxides is crucial for high-quality thin-film fabrication and device applications. Multiple strategies stabilize the phase, with evidence highlighting extra holes’ key role. However, research on
Xixiang Jing, Yuhao Yue, Shuning Lv, Kang Jia, Kepeng Song, Fatoye Sawyerr, Qi Hu, Zekun Zhang, Shu Shi, Shifeng Wen, Li-Min Liu, Jingsheng Chen, Xiaoli Fan, Zheng Wen, Tengfei Cao   +14 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

When happiness strengthens engagement and performance: the role of happiness at work as a resource for experienced employees and newcomers

Frontiers in Psychology
This research investigates the interactive effects of happiness at work and interest taking on work engagement and extra-productive behaviors across experienced employees and newcomers.ObjectiveThe article investigates how happiness at work can serve as ...
Patrik Fröhlich, Elvira Radaca, Stefan Diestel   +2 more
doaj   +1 more source