Results 51 to 60 of about 1,172,315 (295)

Immunogenicity of Extracellular Vesicles

Advances in Materials
Extracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery systems due to demonstrated safety and efficacy in preclinical models and early‐stage clinical trials. There is an urgent need to address the immunogenicity of EVs (
Yutian Xia, Jianzhong Zhang, Gang Liu, Joy Wolfram   +3 more
semanticscholar   +1 more source

Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Journal of Hematology & Oncology, 2021
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines.
Zhijie Weng, Bo-wen Zhang, Chen-zhou Wu, F. Yu, B. Han, Bo Li, Longjiang Li   +6 more
semanticscholar   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

A beginner's guide to study extracellular vesicles in human blood plasma and serum

Journal of Extracellular Vesicles
Blood is the most commonly used body fluid for obtaining and studying extracellular vesicles (EVs). While blood is a standard choice for clinical analysis, using blood as a source of EVs introduces multiple layers of complexity.
R. Nieuwland, P. Siljander
semanticscholar   +1 more source

Liposomes and Extracellular Vesicles as Drug Delivery Systems: A Comparison of Composition, Pharmacokinetics, and Functionalization

Advanced Healthcare Materials, 2021
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught the attention of researchers worldwide, encouraging the field to rapidly develop improved ways for effective drug delivery.
Luke van der Koog, Timea B Gandek, A. Nagelkerke   +2 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. [PDF]

, 2017
RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their coisolation with contaminants, lack of knowledge of the mechanisms of RNA sorting into EVs, and limitations of ...
Lambowitz, Alan M, Nottingham, Ryan M, Qin, Yidan, Schekman, Randy, Shurtleff, Matthew J, Temoche-Diaz, Morayma M, Yao, Jun   +6 more
core   +1 more source

Extracellular vesicles as human therapeutics: A scoping review of the literature

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) are released by all cells and contribute to cell‐to‐cell communication. The capacity of EVs to target specific cells and to efficiently deliver a composite profile of functional molecules have led researchers around the world
Clorinda Fusco, Giusy De Rosa, Ilaria Spatocco, Elisabetta Vitiello, C. Procaccini, Chiara Frigé, Valeria Pellegrini, Rosalba La Grotta, Roberto Furlan, G. Matarese, F. Prattichizzo, P. de Candia   +11 more
semanticscholar   +1 more source

A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum

Scientific Reports, 2020
Extracellular vesicles (EVs) are nano-sized vesicles containing nucleic acid and protein cargo that are released from a multitude of cell types and have gained significant interest as potential diagnostic biomarkers.
K. Brennan, K. Martin, S. Fitzgerald, James O’Sullivan, Y. Wu, A. Blanco, C. Richardson, M. Gee   +7 more
semanticscholar   +1 more source

Overview and Update on Extracellular Vesicles: Considerations on Exosomes and Their Application in Modern Medicine

Biology, 2022
Simple Summary Exosomes are a subpopulation of extracellular vesicles, nanosized particles, lipid bilayer-enclosed, naturally secreted from cells after the fusion of intracellular Multivesicular bodies with the plasma membrane.
M. A. Di Bella
semanticscholar   +1 more source