Results 41 to 50 of about 1,220,088 (267)

An Investigation of Using a Tablet Computer for Searching on the Web and the Influence of Cognitive Load [PDF]

open access: yesTutorials in Quantitative Methods for Psychology, 2020
This paper presents two lab-based experiments that compare laptop and tablet performance in web-based search. Compared to laptops, tablets feature smaller screens and require gestures to interact with them and to input information.
Debue, Nicolas   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

The impact of signaling in E-Learning Videos on extraneous load and retention.

open access: yes, 2022
This computer-based study examines the effect of signaling in short videos in comparison to long videos. The focus will be set on the impact of signaling on extraneous load and retention.
Friederike Luise Hahmann
core   +1 more source

Evaluating an obstetrics and gynecology teaching program for medical students incorporating simulation-based education underpinned by cognitive load theory

open access: yesFrontiers in Medicine
Although there have been previous publications on curriculum innovations in teaching O&G to medical students, especially utilizing simulation-based education, there have been none, as far as we know, incorporating and evaluating the outcomes using ...
William Atiomo   +3 more
doaj   +1 more source

The effect of extraneous cognitive load on task cost and self-efficacy of students [PDF]

open access: yesروان‌شناسی تربیتی
The aim of this study was to investigate the effect of extraneous cognitive load on internal task cost and self-efficacy in students. The research design was semi-experimental with pre-test-post-test with an unequal control group and the statistical ...
Saeideh Zahed   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Understanding instructional design effects by differentiated measurement of intrinsic, extraneous, and germane cognitive load

open access: yes, 2020
Instructional design deals with the optimization of learning processes. To achieve this, three aspects need to be considered: (1) the learning task itself, (2) the design of the learning material, and (3) the activation of the learner’s cognitive ...
Seufert, Tina, Klepsch, Melina
core   +1 more source

Plugging the Attention Deficit: Perceptual Load Counters Increased Distraction in ADHD. [PDF]

open access: yes, 2013
Objective: Increased vulnerability to extraneous distraction is a key symptom of Attention-Deficit Hyperactivity Disorder (ADHD), which may have particularly disruptive consequences.
Forster, S   +14 more
core   +1 more source

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