Extrasynaptic Communication [PDF]
Frontiers in Molecular Neuroscience, 2021 Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel +13 more
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Extrasynaptic and postsynaptic receptors in glycinergic and GABAergic neurotransmission: a division of labor? [PDF]
Frontiers in Molecular Neuroscience, 2008 Glycine and GABA mediate inhibitory neurotransmission in the spinal cord and central nervous system. The general concept of neurotransmission is now challenged by the contribution of both phasic activation of postsynaptic glycine and GABAA receptors ...
Emilie Muller +3 more
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A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity [PDF]
BMC Neuroscience, 2008 Background Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival.
Bading Hilmar +2 more
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Extrasynaptic δ-subunit containing GABAA receptors [PDF]
Journal of Integrative Neuroscience, 2021 γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
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Successful seizure control with cenobamate in juvenile myoclonic epilepsy. [PDF]
Epileptic DisordEpileptic Disorders, Volume 27, Issue 2, Page 307-310, April 2025.
Tényi D, Horváth R, Janszky J.
europepmc +2 more sources
Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices [PDF]
Frontiers in NeuroanatomyExpression of the N-methyl-D-aspartate receptor, particularly when containing the GluN2B subunit (NMDAR-GluN2B), varies across the prefrontal cortex (PFC).
Mary Kate P. Joyce +7 more
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Extrasynaptic δGABAA receptors mediate resistance to migraine-like phenotype in rats [PDF]
The Journal of Headache and PainBackground GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA receptors.
Berkay Alpay +5 more
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Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis
Biomedicines, 2023 (1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response.
Aleksandar R. Zivkovic +5 more
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Frontiers in Cellular Neuroscience, 2022 Rapid increases in cell volume reduce the size of the extracellular space (ECS) and are associated with elevated brain tissue excitability. We recently demonstrated that astrocytes, but not neurons, rapidly swell in elevated extracellular potassium (∧[K+]
Erin Walch +12 more
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The role of spinal cord extrasynaptic α5GABAA receptors in chronic pain
Physiological Reports, 2021 Chronic pain is an incapacitating condition that affects a large population worldwide. Until now, there is no drug treatment to relieve it. The impairment of GABAergic inhibition mediated by GABAA receptors (GABAAR) is considered a relevant factor in ...
Rodolfo Delgado‐Lezama +14 more
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