Metabotropic Regulation of Extrasynaptic GABAA Receptors [PDF]
Frontiers in Neural Circuits, 2013 A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under ...
William Martin Connelly +3 more
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Optochemical profiling of NMDAR molecular diversity at synaptic and extrasynaptic sites [PDF]
The EMBO JournalNeurotransmitter receptors are critical for neuronal communication. They often form large multimeric complexes that differ in their subunit composition, distribution, and signaling properties. N‐methyl‐D‐aspartate receptors (NMDARs), a class of glutamate-
Antoine Sicard +9 more
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Extrasynaptic Communication [PDF]
Frontiers in Molecular Neuroscience, 2021 Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel +13 more
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Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system [PDF]
Frontiers in Physiology, 2012 We review the evidence of exocytosis from extrasynaptic sites in the soma, dendrites and axonal varicosities of central and peripheral neurons of vertebrates and invertebrates, and how it may contribute to signaling in the nervous system.
Citlali eTrueta +1 more
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Extrasynaptic δ-subunit containing GABAA receptors [PDF]
Journal of Integrative Neuroscience, 2021 γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
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A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling [PDF]
Molecular Brain, 2020 The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell ...
Carlos Bas-Orth +4 more
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Re-Evaluation of the Ultrastructural Localization of Tonic GABA-A Receptors [PDF]
PharmaceuticalsCell membrane receptors play key roles in physiological and pathological processes, yet the mechanisms governing their expression and distribution across the plasma membrane remain not completely understood. Broadly, membrane receptors can be categorized
Abraham Rosas-Arellano
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Distribution of Extrasynaptic NMDA Receptors on Neurons [PDF]
The Scientific World Journal, 2012 NMDA receptors are found in both synaptic and extrasynaptic locations on neurons. NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation.
Ronald S. Petralia
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GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus [PDF]
Frontiers in Cellular NeuroscienceGlucagon-like peptide-1 (GLP-1) is a metabolic hormone secreted by L-cells in the gut and it stimulates insulin secretion in the pancreatic islets by activating GLP-1 receptors (GLP-1Rs).
Olga Netsyk +3 more
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Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA‐NCAM in brain aging and Alzheimer's disease [PDF]
Alzheimers DementAbstract Background N‐methyl‐D‐aspartate receptors (NMDARs) are critical for synaptic transmission, with GluN2B subunits playing key roles in synaptic plasticity. Extrasynaptic GluN2Bs (ES‐GluN2Bs) activate long‐term depression (LTD) pathways, potentially promoting dementia in Alzheimer's disease (AD).
Imiruaye O +6 more
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