Results 1 to 10 of about 26,166 (275)

Extrasynaptic δ-subunit containing GABAA receptors [PDF]

open access: yesJournal of Integrative Neuroscience, 2021
γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
doaj   +4 more sources

Extrasynaptic Communication [PDF]

open access: yesFrontiers in Molecular Neuroscience, 2021
Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel   +13 more
doaj   +4 more sources

Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model

open access: greenJournal of Neuroinflammation, 2020
Background A subanesthetic dose of ketamine provides rapid and effective antidepressant effects, but the molecular mechanism remains elusive. It has been reported that overactivation of extrasynaptic GluN2B receptors is associated with the antidepressant
Xiao-Hui Tang   +7 more
doaj   +4 more sources

NMDARs in Alzheimer's Disease: Between Synaptic and Extrasynaptic Membranes. [PDF]

open access: yesInt J Mol Sci
N-methyl-D-aspartate receptors (NMDARs) are glutamate receptors with key roles in synaptic communication and plasticity. The activation of synaptic NMDARs initiates plasticity and stimulates cell survival.
Escamilla S   +2 more
europepmc   +6 more sources

Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease [PDF]

open access: goldMolecular Neurodegeneration, 2023
Stroke and late-onset Alzheimer’s disease (AD) are risk factors for each other; the comorbidity of these brain disorders in aging individuals represents a significant challenge in basic research and clinical practice.
Shan Ping Yu   +4 more
openalex   +2 more sources

The role of spinal cord extrasynaptic α5GABAA receptors in chronic pain

open access: yesPhysiological Reports, 2021
Chronic pain is an incapacitating condition that affects a large population worldwide. Until now, there is no drug treatment to relieve it. The impairment of GABAergic inhibition mediated by GABAA receptors (GABAAR) is considered a relevant factor in ...
Rodolfo Delgado‐Lezama   +14 more
doaj   +2 more sources

A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling [PDF]

open access: goldMolecular Brain, 2020
The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell ...
Carlos Bas-Orth   +4 more
doaj   +2 more sources

Tau is required for the function of extrasynaptic NMDA receptors

open access: yesScientific Reports, 2019
Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent ...
Noemí Pallas-Bazarra   +4 more
doaj   +2 more sources

Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer's disease patients. [PDF]

open access: yesAlzheimers Dement
Synaptic and extrasynaptic distribution of N‐methyl‐D‐aspartate receptors (NMDARs) has not been addressed in the brain from Alzheimer´s disease (AD) subjects, despite their contribution to neurodegeneration.
Escamilla S   +7 more
europepmc   +2 more sources

Extrasynaptic α5GABAA receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord [PDF]

open access: bronzeJournal of Neurophysiology, 2018
Activation of GABAA receptors on sensory axons produces a primary afferent depolarization (PAD) that modulates sensory transmission in the spinal cord.
Ana M. Lucas‐Osma   +7 more
openalex   +2 more sources

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