Extrasynaptic δ-subunit containing GABAA receptors [PDF]
Journal of Integrative Neuroscience, 2021 γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
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Extrasynaptic Communication [PDF]
Frontiers in Molecular Neuroscience, 2021 Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel +13 more
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Journal of Neuroinflammation, 2020 Background A subanesthetic dose of ketamine provides rapid and effective antidepressant effects, but the molecular mechanism remains elusive. It has been reported that overactivation of extrasynaptic GluN2B receptors is associated with the antidepressant
Xiao-Hui Tang +7 more
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NMDARs in Alzheimer's Disease: Between Synaptic and Extrasynaptic Membranes. [PDF]
Int J Mol SciN-methyl-D-aspartate receptors (NMDARs) are glutamate receptors with key roles in synaptic communication and plasticity. The activation of synaptic NMDARs initiates plasticity and stimulates cell survival.
Escamilla S +2 more
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Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease [PDF]
Molecular Neurodegeneration, 2023 Stroke and late-onset Alzheimer’s disease (AD) are risk factors for each other; the comorbidity of these brain disorders in aging individuals represents a significant challenge in basic research and clinical practice.
Shan Ping Yu +4 more
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The role of spinal cord extrasynaptic α5GABAA receptors in chronic pain
Physiological Reports, 2021 Chronic pain is an incapacitating condition that affects a large population worldwide. Until now, there is no drug treatment to relieve it. The impairment of GABAergic inhibition mediated by GABAA receptors (GABAAR) is considered a relevant factor in ...
Rodolfo Delgado‐Lezama +14 more
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A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling [PDF]
Molecular Brain, 2020 The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell ...
Carlos Bas-Orth +4 more
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Tau is required for the function of extrasynaptic NMDA receptors
Scientific Reports, 2019 Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent ...
Noemí Pallas-Bazarra +4 more
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Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer's disease patients. [PDF]
Alzheimers DementSynaptic and extrasynaptic distribution of N‐methyl‐D‐aspartate receptors (NMDARs) has not been addressed in the brain from Alzheimer´s disease (AD) subjects, despite their contribution to neurodegeneration.
Escamilla S +7 more
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Extrasynaptic α5GABAA receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord [PDF]
Journal of Neurophysiology, 2018 Activation of GABAA receptors on sensory axons produces a primary afferent depolarization (PAD) that modulates sensory transmission in the spinal cord.
Ana M. Lucas‐Osma +7 more
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