Extrasynaptic Communication [PDF]
Frontiers in Molecular Neuroscience, 2021 Streams of action potentials or long depolarizations evoke a massive exocytosis of transmitters and peptides from the surface of dendrites, axons and cell bodies of different neuron types.
Francisco F. De-Miguel +13 more
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A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity [PDF]
BMC Neuroscience, 2008 Background Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival.
Bading Hilmar +2 more
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Extrasynaptic and postsynaptic receptors in glycinergic and GABAergic neurotransmission: a division of labor? [PDF]
Frontiers in Molecular Neuroscience, 2008 Glycine and GABA mediate inhibitory neurotransmission in the spinal cord and central nervous system. The general concept of neurotransmission is now challenged by the contribution of both phasic activation of postsynaptic glycine and GABAA receptors ...
Emilie Muller +3 more
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Extrasynaptic δ-subunit containing GABAA receptors [PDF]
Journal of Integrative Neuroscience, 2021 γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
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Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices [PDF]
Frontiers in NeuroanatomyExpression of the N-methyl-D-aspartate receptor, particularly when containing the GluN2B subunit (NMDAR-GluN2B), varies across the prefrontal cortex (PFC).
Mary Kate P. Joyce +7 more
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Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area [PDF]
Frontiers in NeuroscienceExposure of neurons in the brainstem mesopontine tegmental anesthesia area (MPTA) to minute quantities of GABAergic general anesthetics at clinically relevant concentrations is sufficient to induce loss-of-consciousness (LOC), while lesioning this ...
Angham Ibraheem +6 more
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Frontiers in Cellular Neuroscience, 2022 Rapid increases in cell volume reduce the size of the extracellular space (ECS) and are associated with elevated brain tissue excitability. We recently demonstrated that astrocytes, but not neurons, rapidly swell in elevated extracellular potassium (∧[K+]
Erin Walch +12 more
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Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis
Biomedicines, 2023 (1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response.
Aleksandar R. Zivkovic +5 more
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The role of spinal cord extrasynaptic α5GABAA receptors in chronic pain
Physiological Reports, 2021 Chronic pain is an incapacitating condition that affects a large population worldwide. Until now, there is no drug treatment to relieve it. The impairment of GABAergic inhibition mediated by GABAA receptors (GABAAR) is considered a relevant factor in ...
Rodolfo Delgado‐Lezama +14 more
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Frontiers in Physiology, 2012 We review the evidence of exocytosis from extrasynaptic sites in the soma, dendrites and axonal varicosities of central and peripheral neurons of vertebrates and invertebrates, and how it may contribute to signaling in the nervous system.
Citlali eTrueta +1 more
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