Results 91 to 100 of about 26,166 (275)

BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A

Cell Reports, 2015
The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors.
David Lau, C. Peter Bengtson, Bettina Buchthal, Hilmar Bading   +3 more
doaj   +1 more source

The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome

Neurobiology of Disease, 2023
Evidence suggests that inhibition of α/β hydrolase-domain containing 6 (ABHD6) reduces seizures; however, the molecular mechanism of this therapeutic response remains unknown.
Ruth Westenbroek, Joshua Kaplan, Katie Viray, Nephi Stella   +3 more
doaj   +1 more source

Repeated \u3cem\u3eN\u3c/em\u3e-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine [PDF]

, 2007
Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Hearing, Matthew, Kau, Kristen S., Lobner, Doug, Madayag, Aric, Mantsch, John R.   +7 more
core   +1 more source

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine [PDF]

, 2008
Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate ...
A Baskys, A Breier, A Meister, A Meister, AJ Cochilla, AK Malhotra, Aric Madayag, AW MacDonald III, AY Shih, B Moghaddam, B Moghaddam, D Jabaudon, DA Baker, DA Baker, David A Baker, DC Javitt, DD Schoepp, DD Schoepp, DE Featherstone, DM Barch, DP Purohit, DR Weinberger, DS Gupta, DS Lorrain, E Pileblad, ED Luby, F Faltus, F Sams-Dodd, G Hu, G Hu, G Kohr, G Paxinos, GD Pearlson, GJ Marek, H Augustin, H Homayoun, H Sato, H Sies, HB Uylings, HF Bradford, Ilangovan Raju, J Cartmell, J Kilbride, JA Lieberman, James H Meador-Woodruff, JB Manent, JH Cabungcal, JH Krystal, JH Krystal, JM Williamson, JY Kim, K Aoyama, KQ Do, L Lu, Lars V Kristiansen, LE Chavez-Noriega, M D'Ascenzo, M Herrera-Marschitz, M Verhage, ME Jackson, MM Moran, O Valenti, P Steullet, PD Harvey, R Corbett, R Takahata, S Bannai, S Chaki, SA Petersen, SJ Sigrist, SM Deneke, Vahram Haroutunian, W Hauber, W Timmerman, WA Abbott, WE Bunney, Y Huang, ZX Xi, ZX Xi   +78 more
core   +2 more sources

Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus

Glia, Volume 74, Issue 1, January 2026.
In Vrk2‐deficient mice, tonic GABA inhibition is reduced in the mediodorsal thalamus due to impaired astrocytic GABA synthesis. Microglial VRK2 regulates this process via TNF‐α signaling, revealing a glial–glial mechanism of thalamic inhibition.
Dongsu Lee, Go Eun Ha, Yeleen Lee, Denise Lee, Jongseo Lee, Jae Ho Yoon, Leechung Chang, Kyung Won Jo, Ho‐Keun Kwon, Kyong‐Tai Kim, Eunji Cheong   +10 more
wiley   +1 more source

Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes

eLife, 2017
Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and ...
Sang Hak Lee, Chaoyi Jin, En Cai, Pinghua Ge, Yuji Ishitsuka, Kai Wen Teng, Andre A de Thomaz, Duncan Nall, Murat Baday, Okunola Jeyifous, Daniel Demonte, Christopher M Dundas, Sheldon Park, Jary Y Delgado, William N Green, Paul R Selvin   +15 more
doaj   +1 more source

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]

, 2008
Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Kau, Kristen S., Madayag, Aric, Mantsch, John R.   +5 more
core   +1 more source

Fast Interneuron Dysfunction in Laminar Neural Mass Model Reproduces Alzheimer's Oscillatory Biomarkers

Human Brain Mapping, Volume 47, Issue 1, January 2026.
A computational laminar model links fast interneuron dysfunction to early hyperexcitability and late hypoactivity in Alzheimer's disease, reproducing key M/EEG biomarkers and capturing the disease's biphasic electrophysiological progression. ABSTRACT Early‐stage AD involves cortical hyperexcitability, progressing to oscillatory slowing and hypoactivity.
Roser Sanchez‐Todo, Borja Mercadal, Edmundo Lopez‐Sola, Maria Guasch‐Morgades, Gustavo Deco, Giulio Ruffini   +5 more
wiley   +1 more source

Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area

Frontiers in Neuroscience
Exposure of neurons in the brainstem mesopontine tegmental anesthesia area (MPTA) to minute quantities of GABAergic general anesthetics at clinically relevant concentrations is sufficient to induce loss-of-consciousness (LOC), while lesioning this ...
Angham Ibraheem, Kristina Vaso, Anne Minert, Shai-Lee Yatziv, Mark Baron, Marshall Devor, Marshall Devor   +6 more
doaj   +1 more source

Photo-antagonism of the GABAA receptor [PDF]

, 2014
Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
A Sali, A Triller, B Frolund, C Notredame, CG Wermuth, CL Padgett, CM Houston, D Belelli, DA Wagner, DM Kullmann, E Sigel, EF Pettersen, EG Steward, EM Schneider Gasser, EO Mann, F Iqbal, G Jones, G Nyiri, H Kiefer, H Mohler, H Zhong, J Amin, J Isaacson, JG Newell, JG Newell, JH Holden, JJ Chambers, JM Fritschy, JQ Kang, JT Kittler, K Ramamoorthi, L Dubinsky, LB Kier, M Ernst, M Heaulme, M Mortensen, M Mortensen, M Mortensen, M Mortensen, MA Simmonds, MC Ashby, N Zacharias, NG Bowery, O Arunlakshana, P Thomas, PS Miller, R Sathyapriya, RW Olsen, S Ueno, SB Hansen, SC Lummis, SE Westh-Hansen, SE Westh-Hansen, SJ Moss, T Klausberger, T Klausberger, TC Turek, U Resch-Genger, Y Bogdanov, Y Chang   +59 more
core   +1 more source