Results 91 to 100 of about 23,129 (240)

Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus

Glia, Volume 74, Issue 1, January 2026.
In Vrk2‐deficient mice, tonic GABA inhibition is reduced in the mediodorsal thalamus due to impaired astrocytic GABA synthesis. Microglial VRK2 regulates this process via TNF‐α signaling, revealing a glial–glial mechanism of thalamic inhibition.
Dongsu Lee, Go Eun Ha, Yeleen Lee, Denise Lee, Jongseo Lee, Jae Ho Yoon, Leechung Chang, Kyung Won Jo, Ho‐Keun Kwon, Kyong‐Tai Kim, Eunji Cheong   +10 more
wiley   +1 more source

Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus. [PDF]

PLoS ONE, 2011
Neural inhibition plays an important role in auditory processing and attentional gating. Extrasynaptic GABA(A) receptors (GABA(A)R), containing α(4)and δ GABA(A)R subunits, are thought to be activated by GABA spillover outside of the synapse following ...
Ben D Richardson, Lynne L Ling, Victor V Uteshev, Donald M Caspary   +3 more
doaj   +1 more source

Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex [PDF]

, 2013
Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that
A Araque, A Kulak, A Wilmsmeier, B Moghaddam, B Moghaddam, B Oranje, BJ Morris, D Braff, D Lobner, D Matsuzawa, D Piani, DA Baker, DA Baker, David A. Baker, DH Ingvar, DL Braff, DV Pow, FK Graham, G Battaglia, G Franzen, G Paxinos, G Paxinos, G Rajkowska, HH Chen, J Cilia, JA Lieberman, JH Cabungcal, JI Sagara, Jon Resch, JT Coyle, K Japha, K Moussawi, K Moussawi, K Ogita, K Schwabe, K Shimosato, KE Poskanzer, KF Berman, KQ Do, Krista Qualmann, KS Kau, L Deserno, L Pasti, LA Glantz, Linghai Kong, LJ Garey, M Berk, M Berk, M Koch, M Li, M Raffa, MA Geyer, MC Angulo, ME Jackson, MJ Marino, MM Moran, NA Oberheim, NM Veelen van, NR Swerdlow, NR Swerdlow, NR Swerdlow, NR Swerdlow, O Kranich, P Bezzi, P Steullet, R Bridges, R Gysin, R Janaky, S Bannai, S Bannai, S Bannai, SG Potkin, SuJean Choi, T Majic, V Kumari, V Parpura, Victoria Lutgen, VM Goghari, VP Bakshi, WE Bunney, Y Cho, ZC Ye   +81 more
core   +2 more sources

Fast Interneuron Dysfunction in Laminar Neural Mass Model Reproduces Alzheimer's Oscillatory Biomarkers

Human Brain Mapping, Volume 47, Issue 1, January 2026.
A computational laminar model links fast interneuron dysfunction to early hyperexcitability and late hypoactivity in Alzheimer's disease, reproducing key M/EEG biomarkers and capturing the disease's biphasic electrophysiological progression. ABSTRACT Early‐stage AD involves cortical hyperexcitability, progressing to oscillatory slowing and hypoactivity.
Roser Sanchez‐Todo, Borja Mercadal, Edmundo Lopez‐Sola, Maria Guasch‐Morgades, Gustavo Deco, Giulio Ruffini   +5 more
wiley   +1 more source

The activity of isolated neurons and the modulatory state of an isolated nervous system represent a recent behavioural state [PDF]

, 2015
Behavioural/motivational state is known to influence nearly all aspects of physiology and behaviour. The cellular basis of behavioural state control is only partially understood.
Chistopolsky, Ilya A., Dyakonova, Taisia L., Dyakonova, Varvara E, Etsuro, Ito, Hernádi, László   +4 more
core   +1 more source

Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley   +1 more source

Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons

Scientific Reports, 2017
In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs
Qian Yang, Geng Zhu, Dandan Liu, Jue-Gang Ju, Zhen-Hua Liao, Yi-Xin Xiao, Yue Zhang, Naijian Chao, JieJie Wang, Weidong Li, Jian-Hong Luo, Sheng-Tian Li   +11 more
doaj   +1 more source

The Selective Bromodomain and Extra‐Terminal Domain (BET) Inhibitor RVX‐208 Reduces Cocaine‐Seeking Behaviour and Alters Proteomic Pathways in the Nucleus Accumbens

Addiction Biology, Volume 31, Issue 1, January 2026.
Rats treated with the domain‐selective BET inhibitor RVX‐208 during a 2‐week forced abstinence period exhibited a reduction in cocaine‐seeking behaviour but not sucrose seeking or open field behaviour. This treatment effect was associated with proteomic changes in pathways relevant to dopaminergic and glutamatergic signalling in the nucleus accumbens ...
Tyler J. Sacko, Afshin Seyednejad, Jesse Engelhardt, Gregory C. Sartor   +3 more
wiley   +1 more source

Extrasynaptic GABA_AReceptors: Form, Pharmacology, and Function [PDF]

The Journal of Neuroscience, 2009
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAAand GABABreceptors. Recently, a novel form of GABAAreceptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAAreceptors underlie classical “phasic” GABAAreceptor-mediated inhibition (inhibitory postsynaptic currents), tonic ...
Belelli, Delia, Harrison, Neil L., Maguire, Jamie, Macdonald, Robert L., Walker, Matthew C., Cope, David W.   +5 more
openaire   +3 more sources

GABAA receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis

Frontiers in Cellular Neuroscience
GABAA receptors (γ-aminobutyric acid-gated receptors type A; GABAARs), the major structural and functional postsynaptic components of inhibitory synapses in the mammalian brain, belong to a family of GABA-gated Cl−/HCO3− ion channels.
Yusheng Sui, Martin Mortensen, Banghao Yuan, Martin W. Nicholson, Trevor G. Smart, Jasmina N. Jovanovic   +5 more
doaj   +1 more source