Results 101 to 110 of about 23,129 (240)
Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations. [PDF]
, 2014 GABA-A receptors (GABA-ARs) are typically expressed at synaptic or nonsynaptic sites mediating phasic and tonic inhibition, respectively. These two forms of inhibition conjointly control various network oscillations.
Acsády, L. +10 more
core +2 more sources
Psychiatry and Clinical Neurosciences, Volume 80, Issue 1, Page 76-86, January 2026.Aim To evaluate the efficacy and safety of oral zuranolone for 14 days, compared with placebo, in Japanese patients with major depressive disorder (MDD). Methods This multicenter, Phase 3 study was conducted in two parts (70 sites; Japan) including a randomized, double‐blind, placebo‐controlled, parallel‐group part presented herein.
Masaki Kato +8 more
wiley +1 more source
Neurobiology of Disease, 2018 Rett syndrome (RTT) is a devastating neurodevelopmental disorder caused by loss-of-function mutations in the X-linked methyl-CpG binding protein 2 (Mecp2) gene.
Chao-Yin Chen +6 more
doaj +1 more source
Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. [PDF]
, 2012 Tetramethylenedisulfotetramine (TETS) is a potent convulsant that is considered a chemical threat agent. We characterized TETS as an activator of spontaneous Ca²⁺ oscillations and electrical burst discharges in mouse hippocampal neuronal cultures at 13 ...
Cao, Zhengyu +5 more
core +2 more sources
The Journal of Physiology, Volume 604, Issue 2, Page 689-706, 15 January 2026.Abstract figure legend With ageing and age‐related neurodegenerative diseases, the amount of GABA and GABAergic inhibition as well as the modulation (indicated by sine wave) of GABAergic inhibition is reduced, whereas excitation is increased. In many parts of the brain, this leads to a mismatch of facilitatory (green neurons) and inhibitory (red ...
Wolfgang Taube, Benedikt Lauber
wiley +1 more source
Frontiers in Synaptic Neuroscience, 2019 N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic signaling, and alterations in the synaptic/extrasynaptic NMDAR balance affect neuronal survival.
Rujun Kang +5 more
doaj +1 more source
Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein [PDF]
, 2000 Background: Membrane-associated guanylate kinases (MAGUKs) assemble ion channels, cell-adhesion molecules and components of second messenger cascades into synapses, and are therefore potentially important for co-ordinating synaptic strength and structure.
Thomas, U. +7 more
core +1 more source
Insulin Regulates GABAA Receptor-Mediated Tonic Currents in the Prefrontal Cortex
Frontiers in Neuroscience, 2018 Recent studies, have shown that insulin increases extrasynaptic GABAA receptor-mediated currents in the hippocampus, causing alterations of neuronal excitability.
Saraí Trujeque-Ramos +6 more
doaj +1 more source
Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent [PDF]
, 2017 In the mammalian central nervous system (CNS) GABAA receptors (GABAARs) mediate neuronal inhibition and are important therapeutic targets. GABAARs are composed of 5 subunits, drawn from 19 proteins, underpinning expression of 20-30 GABAAR subtypes.
Adam R. Brown +74 more
core +2 more sources
Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT Non‐suicidal self‐injury (NSSI) is a complex and often misunderstood behavior linked to emotional dysregulation, trauma, and substance use. In this case report we present a 19‐year‐old female with a history of childhood trauma and substance use, who engaged in self‐injurious behavior as a coping mechanism to manage distress and maintain ...
Sakshi Prasad +7 more
wiley +1 more source