Results 11 to 20 of about 12,419 (203)
Metabotropic Regulation of Extrasynaptic GABAA Receptors [PDF]
Frontiers in Neural Circuits, 2013 A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under ...
William Martin Connelly +3 more
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Distribution of Extrasynaptic NMDA Receptors on Neurons [PDF]
The Scientific World Journal, 2012 NMDA receptors are found in both synaptic and extrasynaptic locations on neurons. NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation.
Ronald S. Petralia
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Tau is required for the function of extrasynaptic NMDA receptors [PDF]
Scientific Reports, 2019 Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent ...
Noemí Pallas-Bazarra +4 more
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Fast detection of extrasynaptic GABA with a whole-cell sniffer [PDF]
Frontiers in Cellular Neuroscience, 2014 Gamma-amino-butyric acid (GABA) is the main inhibitory transmitter of the brain. It operates by binding to specific receptors located both inside and outside synapses.
Rasmus Kordt Christensen +3 more
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Cerebellar Cortex: Computation by Extrasynaptic Inhibition? [PDF]
Current Biology, 2002 In the cerebellar cortex, inhibitory inputs to granule cells exhibit prominent tonic and spillover components resulting from the activation of extrasynaptic receptors. A recent study shows how extrasynaptic inhibition affects information flow through cerebellar cortex.
Erik De Schutter
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Glutamate-Mediated Extrasynaptic Inhibition [PDF]
Neuron, 2001 Abstract NMDA receptors (NMDARs) typically contribute to excitatory synaptic transmission in the CNS. While Ca 2+ influx through NMDARs plays a critical role in synaptic plasticity, direct actions of NMDAR-mediated Ca 2+ influx on neuronal excitability have not been well established. Here we show that Ca 2+ influx through NMDARs is directly coupled
Jeffry S. Isaacson, Gabe J. Murphy
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Imaging extrasynaptic glutamate dynamics in the brain [PDF]
Proceedings of the National Academy of Sciences, 2010 Glutamate is the major neurotransmitter in the brain, mediating point-to-point transmission across the synaptic cleft in excitatory synapses. Using a glutamate imaging method with fluorescent indicators, we show that synaptic activity generates extrasynaptic glutamate dynamics in the vicinity of active synapses.
Yohei Okubo +8 more
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Regulating anxiety with extrasynaptic inhibition [PDF]
Nature Neuroscience, 2015 Aversive experiences can lead to complex behavioral adaptations including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes, however, are poorly understood. Here, using a combination of behavioral, physiological and optogenetic approaches in mouse, we identify a specific ...
Michael M. Poe +16 more
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Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors [PDF]
Nature, 2022 AbstractType A GABA (γ-aminobutyric acid) receptors represent a diverse population in the mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ- and π-subunits1. αβ, α4βδ, α6βδ and α5βγ receptors favour extrasynaptic localization, and mediate an essential persistent (tonic) inhibitory conductance in many regions of the ...
Kasaragod, Vikram Babu +7 more
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Extracellular space diffusion and extrasynaptic transmission [PDF]
Physiological Research, 2008 The diffusion of neuroactive substances in the extracellular space (ECS) plays an important role in short- and long-distance communication between nerve cells and is the underlying mechanism of extrasynaptic (volume) transmission. The diffusion properties of the ECS are described by three parameters: 1. ECS volume fraction alpha (alpha=ECS volume/total
Eva Syková, L Vargová
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