Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA‐NCAM in brain aging and Alzheimer's disease [PDF]
Alzheimers DementAbstract Background N‐methyl‐D‐aspartate receptors (NMDARs) are critical for synaptic transmission, with GluN2B subunits playing key roles in synaptic plasticity. Extrasynaptic GluN2Bs (ES‐GluN2Bs) activate long‐term depression (LTD) pathways, potentially promoting dementia in Alzheimer's disease (AD).
Imiruaye O +6 more
europepmc +5 more sources
NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. [PDF]
BrainAutoantibodies directed against the N-methyl-D-aspartate receptor (NMDAR-Ab) are pathogenic immunoglobulins detected in patients suffering from NMDAR encephalitis.
Jamet Z +7 more
europepmc +5 more sources
Metabotropic Regulation of Extrasynaptic GABAA Receptors [PDF]
Frontiers in Neural Circuits, 2013 A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under ...
William Martin Connelly +3 more
doaj +5 more sources
Distribution of Extrasynaptic NMDA Receptors on Neurons [PDF]
The Scientific World Journal, 2012 NMDA receptors are found in both synaptic and extrasynaptic locations on neurons. NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation.
Ronald S. Petralia
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Balancing Extrasynaptic Excitation and Synaptic Inhibition within Olfactory Bulb Glomeruli [PDF]
eNeuro, 2019 Glutamatergic transmission in the brain typically occurs at well-defined synaptic connections, but increasing evidence indicates that neural excitation can also occur through activation of “extrasynaptic” glutamate receptors.
David H. Gire +4 more
openalex +2 more sources
GLP-1 selectively enhances tonic GABAA receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus [PDF]
Frontiers in Cellular NeuroscienceGlucagon-like peptide-1 (GLP-1) is a metabolic hormone secreted by L-cells in the gut and it stimulates insulin secretion in the pancreatic islets by activating GLP-1 receptors (GLP-1Rs).
Olga Netsyk +3 more
doaj +2 more sources
Tonic inhibition of accumbal spiny neurons by extrasynaptic 4 GABAA receptors modulates the actions of psychostimulants [PDF]
, 2014 Within the nucleus accumbens (NAc), synaptic GABAA receptors (GABAARs) mediate phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to cocaine.
Belelli, D +8 more
core +3 more sources
Frontiers in Synaptic Neuroscience, 2018 This review article deals with the mechanisms of extrasynaptic release of transmitter substances, namely the release from the soma, axon and dendrites in the absence of postsynaptic counterparts.
Elaine Del-Bel, Francisco F. De-Miguel
doaj +2 more sources
Frontiers in Pharmacology, 2019 Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE ...
Timothy B. C. Johnstone +6 more
doaj +2 more sources
Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons
Scientific Reports, 2017 In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs
Qian Yang +11 more
doaj +2 more sources