Results 21 to 30 of about 26,166 (275)
Cerebellar Cortex: Computation by Extrasynaptic Inhibition? [PDF]
Current Biology, 2002 In the cerebellar cortex, inhibitory inputs to granule cells exhibit prominent tonic and spillover components resulting from the activation of extrasynaptic receptors. A recent study shows how extrasynaptic inhibition affects information flow through cerebellar cortex.
Erik De Schutter
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Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis
Biomedicines, 2023 (1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response.
Aleksandar R. Zivkovic +5 more
doaj +1 more source
Extracellular space diffusion and extrasynaptic transmission
Physiological Research, 2008 The diffusion of neuroactive substances in the extracellular space (ECS) plays an important role in short- and long-distance communication between nerve cells and is the underlying mechanism of extrasynaptic (volume) transmission. The diffusion properties of the ECS are described by three parameters: 1. ECS volume fraction alpha (alpha=ECS volume/total
Lýdia Vargová, Eva Syková
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Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors
Nature, 2022 Type A GABA (γ-aminobutyric acid) receptors represent a diverse population in the mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ- and π-subunits1. αβ, α4βδ, α6βδ and α5βγ receptors favour extrasynaptic localization, and
V. B. Kasaragod +7 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2022 Rapid increases in cell volume reduce the size of the extracellular space (ECS) and are associated with elevated brain tissue excitability. We recently demonstrated that astrocytes, but not neurons, rapidly swell in elevated extracellular potassium (∧[K+]
Erin Walch +12 more
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Journal of Neuroscience, 2021 Synaptic and neuronal loss are major neuropathological characteristics of Parkinson's disease. Misfolded protein aggregates in the form of Lewy bodies, comprised mainly of α-synuclein (αSyn), are associated with disease progression, and have also been ...
Dorit Trudler +10 more
semanticscholar +1 more source
Imaging extrasynaptic glutamate dynamics in the brain [PDF]
Proceedings of the National Academy of Sciences, 2010 Glutamate is the major neurotransmitter in the brain, mediating point-to-point transmission across the synaptic cleft in excitatory synapses. Using a glutamate imaging method with fluorescent indicators, we show that synaptic activity generates extrasynaptic glutamate dynamics in the vicinity of active synapses.
Yohei Okubo +8 more
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Synaptic NMDA receptors mediate hypoxic excitotoxic death [PDF]
, 2012 Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia.
Wroge, Christine M +3 more
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Regulating anxiety with extrasynaptic inhibition [PDF]
Nature Neuroscience, 2015 Aversive experiences can lead to complex behavioral adaptations including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes, however, are poorly understood. Here, using a combination of behavioral, physiological and optogenetic approaches in mouse, we identify a specific ...
Botta P. +13 more
openaire +3 more sources