Results 21 to 30 of about 26,166 (275)

Cerebellar Cortex: Computation by Extrasynaptic Inhibition? [PDF]

open access: bronzeCurrent Biology, 2002
In the cerebellar cortex, inhibitory inputs to granule cells exhibit prominent tonic and spillover components resulting from the activation of extrasynaptic receptors. A recent study shows how extrasynaptic inhibition affects information flow through cerebellar cortex.
Erik De Schutter
openalex   +4 more sources

Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis

open access: yesBiomedicines, 2023
(1) Background: Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response.
Aleksandar R. Zivkovic   +5 more
doaj   +1 more source

Extracellular space diffusion and extrasynaptic transmission

open access: goldPhysiological Research, 2008
The diffusion of neuroactive substances in the extracellular space (ECS) plays an important role in short- and long-distance communication between nerve cells and is the underlying mechanism of extrasynaptic (volume) transmission. The diffusion properties of the ECS are described by three parameters: 1. ECS volume fraction alpha (alpha=ECS volume/total
Lýdia Vargová, Eva Syková
openalex   +3 more sources

Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors

open access: yesNature, 2022
Type A GABA (γ-aminobutyric acid) receptors represent a diverse population in the mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ- and π-subunits1. αβ, α4βδ, α6βδ and α5βγ receptors favour extrasynaptic localization, and
V. B. Kasaragod   +7 more
semanticscholar   +1 more source

Contributions of Astrocyte and Neuronal Volume to CA1 Neuron Excitability Changes in Elevated Extracellular Potassium

open access: yesFrontiers in Cellular Neuroscience, 2022
Rapid increases in cell volume reduce the size of the extracellular space (ECS) and are associated with elevated brain tissue excitability. We recently demonstrated that astrocytes, but not neurons, rapidly swell in elevated extracellular potassium (∧[K+]
Erin Walch   +12 more
doaj   +1 more source

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

open access: yesJournal of Neuroscience, 2021
Synaptic and neuronal loss are major neuropathological characteristics of Parkinson's disease. Misfolded protein aggregates in the form of Lewy bodies, comprised mainly of α-synuclein (αSyn), are associated with disease progression, and have also been ...
Dorit Trudler   +10 more
semanticscholar   +1 more source

Imaging extrasynaptic glutamate dynamics in the brain [PDF]

open access: greenProceedings of the National Academy of Sciences, 2010
Glutamate is the major neurotransmitter in the brain, mediating point-to-point transmission across the synaptic cleft in excitatory synapses. Using a glutamate imaging method with fluorescent indicators, we show that synaptic activity generates extrasynaptic glutamate dynamics in the vicinity of active synapses.
Yohei Okubo   +8 more
openalex   +3 more sources

Synaptic NMDA receptors mediate hypoxic excitotoxic death [PDF]

open access: yes, 2012
Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia.
Wroge, Christine M   +3 more
core   +3 more sources

Regulating anxiety with extrasynaptic inhibition [PDF]

open access: yesNature Neuroscience, 2015
Aversive experiences can lead to complex behavioral adaptations including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes, however, are poorly understood. Here, using a combination of behavioral, physiological and optogenetic approaches in mouse, we identify a specific ...
Botta P.   +13 more
openaire   +3 more sources

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