Results 31 to 40 of about 26,166 (275)
International Journal of Molecular Sciences, 2022 Duchenne muscular dystrophy (DMD) is a neurodevelopmental disorder primarily caused by the loss of the full-length Dp427 dystrophin in both muscle and brain. The basis of the central comorbidities in DMD is unclear.
Faouzi Zarrouki +6 more
semanticscholar +1 more source
Diffusion-based neuromodulation can eliminate catastrophic forgetting in simple neural networks [PDF]
, 2017 A long-term goal of AI is to produce agents that can learn a diversity of skills throughout their lifetimes and continuously improve those skills via experience. A longstanding obstacle towards that goal is catastrophic forgetting, which is when learning
Clune, Jeff, Velez, Roby
core +7 more sources
Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce symmetric undulation
Current Biology, 2021 In many animals, there is a direct correspondence between the motor patterns that drive locomotion and the motor neuron innervation onto the muscle groups. For example, the adult C.
Yangning Lu +11 more
semanticscholar +1 more source
Extrasynaptic NMDA Receptors Bidirectionally Modulate Intrinsic Excitability of Inhibitory Neurons
Journal of Neuroscience, 2021 The NMDA subtype glutamate receptors (NMDARs) play important roles in both physiological and pathologic processes in the brain. Compared with their critical roles in synaptic modifications and excitotoxicity in excitatory neurons, much less is understood
Lulu Yao +11 more
semanticscholar +1 more source
Glutamate-Mediated Extrasynaptic Inhibition [PDF]
Neuron, 2001 Abstract NMDA receptors (NMDARs) typically contribute to excitatory synaptic transmission in the CNS. While Ca 2+ influx through NMDARs plays a critical role in synaptic plasticity, direct actions of NMDAR-mediated Ca 2+ influx on neuronal excitability have not been well established. Here we show that Ca 2+ influx through NMDARs is directly coupled
Isaacson, Jeffry S., Murphy, Gabe J.
openaire +1 more source
Ascaris suum Informs Extrasynaptic Volume Transmission in Nematodes [PDF]
ACS Chemical Neuroscience, 2021 Neural circuit synaptic connectivities (the connectome) provide the anatomical foundation for our understanding of nematode nervous system function. However, other nonsynaptic routes of communication are known in invertebrates including extrasynaptic volume transmission (EVT), which enables short- and/or long-range communication in the absence of ...
Louise E. Atkinson +14 more
openaire +5 more sources
Extrasynaptic NMDA Receptor in Excitotoxicity [PDF]
The Neuroscientist, 2014 It is generally accepted that proper activation of N-methyl-d-aspartate receptors (NMDARs) promotes neuronal survival and supports neuroplasticity, and excessive NMDAR activation leads to pathological outcomes and neurodegeneration. As NMDARs are found at both synaptic and extrasynaptic sites, there is significant interest in determining how NMDARs at
Xianju, Zhou +5 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2008 Glycine and GABA mediate inhibitory neurotransmission in the spinal cord and central nervous system. The general concept of neurotransmission is now challenged by the contribution of both phasic activation of postsynaptic glycine and GABAA receptors ...
Emilie Muller +3 more
doaj +1 more source
AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury. [PDF]
, 2015 Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms ...
Beattie, Michael S +7 more
core +1 more source
Extrasynaptic neuron-glia communication [PDF]
Communicative & Integrative Biology, 2011 Chemical synaptic transmission between neurons is believed to take place at specialized sites of cell contact, comprising presynaptic terminals and postsynaptic membranes. Neurotransmitter release has been shown to occur also extrasynaptically, mainly targeting glial cells. In a recent study, we investigated the mechanism of extrasynaptic glutamate and
Christian, Lohr +2 more
openaire +2 more sources