Results 31 to 40 of about 12,419 (203)
Extrasynaptic Neurotransmission as a Way of Modulating Neuronal Functions [PDF]
Frontiers in Physiology, 2012 Extrasynaptic neurotransmission allows neuronal communication at variable distances, based on the release and diffusion of chemical substances from the soma, axon, or dendrites of neurons, or after transmitter leak-out from the synaptic cleft (De-Miguel and Trueta, 2005; Fuxe et al., 2007).
Kjell Fuxe, Francisco F. De-Miguel
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Tonic neuromodulation of the inspiratory rhythm generator
Frontiers in Physiology, 2012 The generation of neural network dynamics relies on the interactions between the intrinsic and synaptic properties of their neural components. Moreover, neuromodulators allow networks to change these properties and adjust their activity to specific ...
Fernando ePeña-Ortega
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Molecular Brain, 2023 Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation.
Guilherme M. Gomes +3 more
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Frontiers in Cellular Neuroscience, 2014 The soma of many neurons releases large amounts of transmitter molecules through an exocytosis process that continues for hundreds of seconds after the end of the triggering stimulus.
Carolina eLeon-Pinzon +4 more
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Extrasynaptic NMDA Receptor in Excitotoxicity [PDF]
The Neuroscientist, 2014 It is generally accepted that proper activation of N-methyl-d-aspartate receptors (NMDARs) promotes neuronal survival and supports neuroplasticity, and excessive NMDAR activation leads to pathological outcomes and neurodegeneration. As NMDARs are found at both synaptic and extrasynaptic sites, there is significant interest in determining how NMDARs at
Zhuoyou Chen +5 more
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Frontiers in Physiology, 2012 Extrasynaptic neurotransmission is an important short distance form of volume transmission (VT) and describes the extracellular diffusion of transmitters and modulators after synaptic spillover or extrasynaptic release in the local circuit regions ...
Kjell eFuxe +11 more
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Frontiers in Behavioral Neuroscience, 2014 Dopamine mediates diverse functions such as motivation, reward, attention, learning/memory and sleep/arousal. Recent studies using model organisms including the fruit fly, have elucidated various physiological functions of dopamine, and identified ...
Taro eUeno +3 more
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Extrasynaptic GABAAReceptors: Form, Pharmacology, and Function [PDF]
The Journal of Neuroscience, 2009 GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAAand GABABreceptors. Recently, a novel form of GABAAreceptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAAreceptors underlie classical “phasic” GABAAreceptor-mediated inhibition (inhibitory postsynaptic currents), tonic ...
Belelli, Delia +5 more
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Pharmaceuticals, 2023 With the discovery that the acquisition of toxic features by extrasynaptic NMDA receptors (NMDARs) involves their physical interaction with the non-selective cation channel, TRPM4, it has become possible to develop a new pharmacological principle for ...
Jing Yan, Hilmar Bading
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Thermodynamic Efficiency of Somatic Exocytosis of Serotonin
Frontiers in Physiology, 2019 Through somatic exocytosis neurons liberate immense amounts of transmitter molecules that modulate the functioning of the nervous system. A stream of action potentials triggers an ATP-dependent transport of transmitter-containing vesicles to the plasma ...
Paula Noguez +2 more
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