Results 41 to 50 of about 12,502 (205)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Extrasynaptic site of action for γ-hydroxybutyrate [PDF]

Proceedings of the National Academy of Sciences, 2012
Advances in pharmacology often result from identifying the mechanism of action of drugs found empirically to be biologically active (1). γ-Hydroxybutyric acid (GHB), also known as Fantasy, is a centrally active agent that has been used clinically and recreationally for nearly half a century.
openaire   +3 more sources

GABA potency at GABAA receptors found in synaptic and extrasynaptic zones

Frontiers in Cellular Neuroscience, 2012
The potency of GABA is vitally important for its primary role in activating GABAA receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often ...
Martin eMortensen, Bijal ePatel, Trevor G. Smart   +2 more
doaj   +1 more source

Craving self‐reports as outcome measures in drug addiction trials: A systematic review of ClinicalTrials.gov

Addiction, EarlyView.
Abstract Background and Aims The subjective experience of drug craving is characterized by an overwhelming urge to consume substances. Due to strong validity and ease of use, self‐report measures are widely employed to assess substance‐related motivational dynamics.
Matin Toulami, Keyvan Ghasemi, Parnian Rafei, Arshiya Sangchooli, Nastaran Nafissi, Arash Khojasteh Zonoozi, Hossein Mohaddes Ardabili, Mohsen Ebrahimi, Tara Rezapour, Hamed Ekhtiari   +9 more
wiley   +1 more source

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Anorectic and anxiogenic actions of cocaine‐ and amphetamine‐regulated transcript in the lateral septum

Journal of Neuroendocrinology, EarlyView.
Abstract Cocaine‐ and amphetamine‐regulated transcript (CART) is produced in several brain regions including the hypothalamus where it is made in cells that also produce melanin‐concentrating hormone (MCH). CART‐expressing MCH cells densely innervate the lateral septum (LS), which integrates food‐ and mood‐related behaviours.
Anjali Shankhatheertha, Mikayla A. Payant, Jenny Phy‐Lim, Melissa J. Chee   +3 more
wiley   +1 more source

Presynaptic and extrasynaptic regulation of posterior nucleus of thalamus [PDF]

Journal of Neurophysiology, 2017
The posterior nucleus of thalamus (PO) is a higher-order nucleus involved in sensorimotor processing, including nociception. An important characteristic of PO is its wide range of activity profiles that vary across states of arousal, thought to underlie differences in somatosensory perception subject to attention and degree of consciousness ...
Anthony Park, Ying Li, Radi Masri, Asaf Keller   +3 more
openaire   +3 more sources

Pathophysiological power of improper tonic GABAA conductances in mature and immature models

Frontiers in Neural Circuits, 2013
High-affinity extrasynaptic gamma-aminobutyric acid A (GABAA) receptors are tonically activated by low and consistent levels of ambient GABA, mediating chronic inhibition against neuronal excitability (tonic inhibition) and the modulation of neural ...
Kiyoshi eEgawa, Atsuo eFukuda
doaj   +1 more source

Changes in the cortical GABAergic inhibitory system with ageing and ageing‐related neurodegenerative diseases

The Journal of Physiology, EarlyView.
Abstract figure legend With ageing and age‐related neurodegenerative diseases, the amount of GABA and GABAergic inhibition as well as the modulation (indicated by sine wave) of GABAergic inhibition is reduced, whereas excitation is increased. In many parts of the brain, this leads to a mismatch of facilitatory (green neurons) and inhibitory (red ...
Wolfgang Taube, Benedikt Lauber
wiley   +1 more source

Rapid homeostatic downregulation of LTP by extrasynaptic GluN2B receptors [PDF]

Journal of Neurophysiology, 2018
Although the activation of extrasynaptic GluN2B-containing N-methyl-d-aspartate (NMDA) receptors has been implicated in neurodegenerative diseases, such as Alzheimer’s and Huntington’s disease, their physiological function remains unknown. In this study, we found that extrasynaptic GluN2B receptors play a homeostatic role by antagonizing long-term ...
Jary Y. Delgado, Ann E. Fink, Seth G. N. Grant, Thomas J. O'Dell, Patricio Opazo   +4 more
openaire   +5 more sources