Results 41 to 50 of about 23,129 (240)

Oligomerization and cell surface expression of recombinant GABAA receptors tagged in the δ subunit

Journal of Integrative Neuroscience, 2019
The γ-Aminobutyric acid type A receptors (GABAARs) are heteropentameric chloride channels responsible for primary inhibition in the mammalian brain.
Furkan Enes Oflaz, Çağdaş Devrim Son, Ayla Arslan   +2 more
doaj   +1 more source

Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

Frontiers in Pharmacology, 2019
Seizures induced by organophosphorus nerve agent exposure become refractory to treatment with benzodiazepines because these drugs engage synaptic γ-aminobutyric acid-A receptors (GABAARs) that rapidly internalize during status epilepticus (SE ...
Timothy B. C. Johnstone, Hilary S. McCarren, Jay Spampanato, F. Edward Dudek, John H. McDonough, Derk Hogenkamp, Kelvin W. Gee   +6 more
doaj   +1 more source

Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs [PDF]

, 2004
AMPA receptors (AMPARs) are dynamically regulated at synapses, but the time course and location of their exocytosis and endocytosis are not known. Therefore, we have used ecliptic pHluorin-tagged glutamate receptor 2 to visualize changes in AMPAR surface
Ashby, MC, Collingridge, Graham L, De La Rue, Sarah A, Henley, Jeremy, Ralph, GS, Uney, James   +5 more
core   +2 more sources

Extrasynaptic vesicle recycling in mature hippocampal neurons [PDF]

Nature Communications, 2011
Fast neuronal signalling relies on highly regulated vesicle fusion and recycling at specialized presynaptic terminals. Recently, examples of non-classical neurotransmission have also been reported, where fusion of vesicles can occur at sites remote from conventional synapses.
Ratnayaka, Arjuna, Marra, Vincenzo, Branco, Tiago, Staras, Kevin   +3 more
openaire   +3 more sources

Tonic neuromodulation of the inspiratory rhythm generator

Frontiers in Physiology, 2012
The generation of neural network dynamics relies on the interactions between the intrinsic and synaptic properties of their neural components. Moreover, neuromodulators allow networks to change these properties and adjust their activity to specific ...
Fernando ePeña-Ortega
doaj   +1 more source

A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death

Molecular Brain, 2023
Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation.
Guilherme M. Gomes, Julia Bär, Anna Karpova, Michael R. Kreutz   +3 more
doaj   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
A Barberis, A Scimemi, A Tao, A Triller, AE Spruce, AG Ogston, AI Gulyas, AM Aravanis, Annalisa Scimemi, AV Hill, B Barbour, B Ceccarelli, B Granseth, B Katz, C Auger, C Nicholson, C Nicholson, C Nicholson, C Racca, D Colquhoun, D Colquhoun, D Sulzer, DA Rusakov, DE Bergles, DM Kullmann, DR Copenhagen, E Betzig, E Neher, E Sykova, EL Botvinick, EN Pothos, EP Huang, F Asztely, F Pouille, G Brasnjo, G Liu, G Szapiro, G Tong, GH Acheson, GH Patterson, H Korn, H Korn, H Shroff, HC Hartzell, IM Raman, J Balaji, J Castillo Del, J Hrabe, J Matthews-Bellinger, J Szabadics, JC Eccles, JC Eccles, JC Eccles, JD Clements, JE Heuser, JH Singer, JI Wadiche, JI Wadiche, JJ Celentano, JM Bekkers, JM Christie, JM Fernandez, JR Stiles, JS Diamond, JS Diamond, JS Diamond, JW Mozrzymas, JW Mozrzymas, K Belaya, K Krnjevic, K Luby-Phelps, K Zheng, KA Foster, KE Sorra, KL Magleby, KM Franks, KP Lehre, L He, L Tao, LG Longsworth, LM Levy, LM Wahl, LP Savtchenko, LS Overstreet, M Beato, M Beato, M Beato, MA Medina, Marco Beato, MI Banks, MJ Higley, MV Jones, MY Min, N Arnth-Jensen, N Harata, N Riveros, NC Harata, O Prange, P Fatt, P Fatt, P Legendre, PJ Kruk, PM Burger, Q Zhang, Q Zhang, R Ando, R Conti, R Renden, R Ventura, RG Thorne, RH Chow, RM Wightman, RW Daniels, RY Tsien, S Habuchi, S Hrabetova, S Manley, S Namiki, S Okumoto, S Takamori, SA Hires, SJ Pitt, SP Gandhi, SW Kuffler, SY Breusegem, T Lu, T Schikorski, T Schikorski, TA Nielsen, TG Allen, TG Banke, TG Oertner, TM Bartol Jr, V Burzomato, VA Levin, W Almers, W Lu, X Chen, XS Wu, Y Dehnes, Y Takumi, YH Huang, Z Nusser, Z Petrasek, Z Petrasek   +144 more
core   +2 more sources

Exocytosis of serotonin from the neuronal soma is sustained by a serotonin and calcium-dependent feedback loop

Frontiers in Cellular Neuroscience, 2014
The soma of many neurons releases large amounts of transmitter molecules through an exocytosis process that continues for hundreds of seconds after the end of the triggering stimulus.
Carolina eLeon-Pinzon, Montserrat G. Cercós, Paula eNoguez, Citlali eTrueta, Francisco eF. De-Miguel   +4 more
doaj   +1 more source

GABA_BReceptors Regulate Extrasynaptic GABA_AReceptors [PDF]

The Journal of Neuroscience, 2013
Tonic inhibitory GABAAreceptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells, and cerebellar granule cells. Here we show that in rat brain slices, activation of postsynaptic GABABreceptors enhances the magnitude of the tonic GABAAcurrent ...
Connelly, William, Fyson, Sarah J., Errington, Adam, McCafferty, Cian P., Cope, David W., Di Giovanni, Giuseppe, Crunelli, Vincenzo   +6 more
openaire   +4 more sources

Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks

Frontiers in Physiology, 2012
Extrasynaptic neurotransmission is an important short distance form of volume transmission (VT) and describes the extracellular diffusion of transmitters and modulators after synaptic spillover or extrasynaptic release in the local circuit regions ...
Kjell eFuxe, Dasiel Oscar Borroto-Escuela, Wilber eRomero-Fernandez, Zaida eDiaz Cabiale, Alicia eRivera, Luca eFerraro, Sergio eTanganelli, Alexander O Tarakanov, Pere eGarriga, Jose A. eNarvaez, Francisco eCiruela, Luigi F Agnati   +11 more
doaj   +1 more source