Results 51 to 60 of about 12,502 (205)

GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus

The Journal of Physiology, EarlyView.
Abstract figure legend Here, we find that GluN2D‐containing NMDA receptors (NMDARs) are expressed by most vasoactive intestinal peptide neurons in the inferior colliculus (IC). These receptors are less susceptible to Mg2+ blockade compared to GluN2A/B‐containing NMDARs, allowing ions to flow at resting membrane potential.
Audrey C. Drotos, Rachel L. Zarb, Victoria Booth, Michael T. Roberts   +3 more
wiley   +1 more source

Differential Astrocyte‐Supplied NMDAR Co‐Agonist for CA1 Versus Dentate Gyrus Long‐Term Potentiation

Hippocampus, Volume 35, Issue 5, September 2025.
ABSTRACT In the hippocampus, there is a region‐ and synapse‐specific N‐methyl‐D‐aspartate receptor (NMDAR) co‐agonist preference for induction of long‐term potentiation (LTP). Schaffer collateral (SC)‐CA1 synapses, enriched in GluN2A‐containing NMDARs, favor D‐serine, while medial perforant path (MPP) to dentate gyrus (DG) synapses that are rich in ...
Shruthi Sateesh, Wickliffe C. Abraham
wiley   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, Volume 45, Issue 5, Page 1407-1422, September 2025.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A

Cell Reports, 2015
The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors.
David Lau, C. Peter Bengtson, Bettina Buchthal, Hilmar Bading   +3 more
doaj   +1 more source

Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus. [PDF]

PLoS ONE, 2011
Neural inhibition plays an important role in auditory processing and attentional gating. Extrasynaptic GABA(A) receptors (GABA(A)R), containing α(4)and δ GABA(A)R subunits, are thought to be activated by GABA spillover outside of the synapse following ...
Ben D Richardson, Lynne L Ling, Victor V Uteshev, Donald M Caspary   +3 more
doaj   +1 more source

Microglial Transient Receptor Potential Melastatin 2 Deficiency Accelerates Seizure Development via Increasing AMPAR‐Mediated Neuronal Excitability

MedComm, Volume 6, Issue 8, August 2025.
The deficiency of transient receptor potential melastatin type 2 (TRPM2) channel as a calcium permeable nonselective cation channel, accelerates seizure development in various mouse seizure models including PTZ‐, KA‐, and kindling‐induced models, but does not affect seizure susceptibility in initial acute seizure. Interestingly, the deficiency of TRPM2
Yingwei Xu, Luyu Ye, Zhisheng Li, Yi Zhang, Ning Hua, Xiaojun Wang, Wangjialu Lu, Jing Xi, Liying Chen, Cenglin Xu, Jiajia Fang, Jianhong Luo, Linhua Jiang, Feng Han, Zhong Chen, Yi Wang, Wei Yang   +16 more
wiley   +1 more source

Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes

eLife, 2017
Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and ...
Sang Hak Lee, Chaoyi Jin, En Cai, Pinghua Ge, Yuji Ishitsuka, Kai Wen Teng, Andre A de Thomaz, Duncan Nall, Murat Baday, Okunola Jeyifous, Daniel Demonte, Christopher M Dundas, Sheldon Park, Jary Y Delgado, William N Green, Paul R Selvin   +15 more
doaj   +1 more source

Phosphoinositide‐ and Collybistin‐Dependent Synaptic Clustering of Gephyrin

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Gephyrin is the main scaffolding protein at inhibitory synapses, clustering glycine and GABAA receptors. At specific GABAergic synapses, collybistin recruits gephyrin to the postsynaptic membrane via interaction with phosphoinositides. Here, we show that collybistin not only mediates membrane targeting but also induces gephyrin self‐oligomerization ...
Nele Burdina, Filip Liebsch, Arthur Macha, Joaquín Lucas Ortuño Gil, Pia Frommelt, Irina Rais, Fabian Basler, Simon Pöpsel, Guenter Schwarz   +8 more
wiley   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling

Molecular Brain, 2020
The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell ...
Carlos Bas-Orth, Mirja Koch, David Lau, Bettina Buchthal, Hilmar Bading   +4 more
doaj   +1 more source