Results 51 to 60 of about 26,166 (275)

Augmented Cystine–Glutamate Exchange by Pituitary Adenylate Cyclase-activating Polypeptide Signaling via the VPAC1 Receptor [PDF]

, 2014
In the central nervous system, cystine import in exchange for glutamate through system xc- is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system
Arimura, Ashur-Fabian, Asztely, Baker, Baker, Baker, Bannai, Bannai, Barger, Berman, Brenneman, Brown, Chen, Choi, Costa, Diamond, Dickson, Dugan, Fahrenkrug, Figiel, Fogal, Ghatei, Grant, Grant, Grimaldi, Grimaldi, Groot, Hannibal, Hannibal, Hashimoto, Jackman, Johnson, Joo, Joo, Knackstedt, Kranich, Kupchik, Lewerenz, Liu, Liu, Liu, Liu, Lobner, Macdonald, Magistretti, Martin, Masmoudi-Kouki, Masmoudi-Kouki, Moran, Morio, Murphy, Park, Piani, Pow, Rush, Rush, Sagara, Said, Sato, Schwartz, Seaborn, Shih, Shintani, Sontheimer, Suh, Suzuki, Tatsuno, Tatsuno, Vaudry, Vaudry, Yaka, Ye, Yuhara, Zheng, Zhou   +74 more
core   +2 more sources

Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]

, 2020
OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A, Joshi, Suchitra, Kapur, Jaideep, Roden, William H   +3 more
core   +2 more sources

Leptin Contributes to Neuropathic Pain via Extrasynaptic NMDAR-nNOS Activation

Molecular Neurobiology, 2020
Leptin is an adipocytokine that is primarily secreted by white adipose tissue, and it contributes to the pathogenesis of neuropathic pain in collaboration with N-methyl-D-aspartate receptors (NMDARs).
Yanling Liang, Yuxin Ma, Jieqin Wang, L. Nie, Xusheng Hou, Wenyu Wu, Xingmei Zhang, Yinghong Tian   +7 more
semanticscholar   +1 more source

A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death

Molecular Brain, 2023
Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation.
Guilherme M. Gomes, Julia Bär, Anna Karpova, Michael R. Kreutz   +3 more
doaj   +1 more source

Realising the therapeutic potential of neuroactive steroid modulators of the GABA_A receptor [PDF]

, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia, Gee, Kelvin W., Hogenkamp, Derk, Lambert, Jeremy J.   +3 more
core   +1 more source

Rapid Exchange of Synaptic and Extrasynaptic NMDA Receptors in Hippocampal CA1 Neurons.

Journal of Neurophysiology, 2020
NMDARs are fundamental coincidence detectors of synaptic activity necessary for the induction of synaptic plasticity and synapse stability. Adjusting NMDAR synaptic content, whether by receptor insertion or lateral diffusion between extrasynaptic and ...
Andrea McQuate, A. Barria
semanticscholar   +1 more source

Activation of Extrasynaptic Kainate Receptors Drives Hilar Mossy Cell Activity

Journal of Neuroscience, 2021
Mossy cells (MCs) of the dentate gyrus are key components of an excitatory associative circuit established by reciprocal connections with dentate granule cells (GCs).
Czarina Ramos, S. Lutzu, Miwako Yamasaki, Y. Yanagawa, K. Sakimura, S. Tomita, Masahiko Watanabe, P. Castillo   +7 more
semanticscholar   +1 more source

Extrasynaptic vesicle recycling in mature hippocampal neurons [PDF]

Nature Communications, 2011
Fast neuronal signalling relies on highly regulated vesicle fusion and recycling at specialized presynaptic terminals. Recently, examples of non-classical neurotransmission have also been reported, where fusion of vesicles can occur at sites remote from conventional synapses.
Ratnayaka, Arjuna, Marra, Vincenzo, Branco, Tiago, Staras, Kevin   +3 more
openaire   +3 more sources

Tonic neuromodulation of the inspiratory rhythm generator

Frontiers in Physiology, 2012
The generation of neural network dynamics relies on the interactions between the intrinsic and synaptic properties of their neural components. Moreover, neuromodulators allow networks to change these properties and adjust their activity to specific ...
Fernando ePeña-Ortega
doaj   +1 more source

DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease

Frontiers in Cellular Neuroscience, 2020
Huntington disease (HD) is a devastating neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. Disrupted cortico-striatal transmission is an early event that contributes to neuronal spine and synapse dysfunction primarily in
Mandi E. Schmidt, N. Caron, A. Aly, Fanny L. Lemarié, Louisa Dal Cengio, Y. Ko, N. Lazic, Lisa M. Anderson, Betty Nguyen, L. Raymond, M. Hayden   +10 more
semanticscholar   +1 more source