Results 61 to 70 of about 12,419 (203)

Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons

Scientific Reports, 2017
In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs
Qian Yang, Geng Zhu, Dandan Liu, Jue-Gang Ju, Zhen-Hua Liao, Yi-Xin Xiao, Yue Zhang, Naijian Chao, JieJie Wang, Weidong Li, Jian-Hong Luo, Sheng-Tian Li   +11 more
doaj   +1 more source

A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling

Molecular Brain, 2020
The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell ...
Carlos Bas-Orth, Mirja Koch, David Lau, Bettina Buchthal, Hilmar Bading   +4 more
doaj   +1 more source

Sodium Oxybate‐Treated Familial Myoclonus‐Dystonia Syndrome Due to Novel SGCE Variant

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Myoclonus‐dystonia syndrome (MDS, OMIM #159900) is an autosomal‐dominant movement disorder caused by heterozygous variants in the epsilon sarcoglycan gene (SGCE) and characterized by a combination of myoclonic jerks, dystonia, and psychiatric comorbidities.
Malak Ali Alghamdi, Muddathir H. Hamad, Isra Alghamdi, Ghiada Alghamdi, Muneera Al‐Jelaify, Sohaila Alshimemeri, Hebattalah Hamed, Nouran Adly, Mustafa A. Salih, Naif A. Almontashiri, Fahad A. Bashiri   +10 more
wiley   +1 more source

Insulin Regulates GABAA Receptor-Mediated Tonic Currents in the Prefrontal Cortex

Frontiers in Neuroscience, 2018
Recent studies, have shown that insulin increases extrasynaptic GABAA receptor-mediated currents in the hippocampus, causing alterations of neuronal excitability.
Saraí Trujeque-Ramos, Diego Castillo-Rolón, Elvira Galarraga, Dagoberto Tapia, Gabina Arenas-López, Stefan Mihailescu, Salvador Hernández-López   +6 more
doaj   +1 more source

Distribution and morphology of serotonin transporter‐immunoreactive type I cells in the rat carotid body

The Anatomical Record, Volume 308, Issue 5, Page 1504-1516, May 2025.
Abstract The present study reexamined the immunolocalization of membranous serotonin transporter (SERT) in the rat carotid body, and demonstrated SERT‐immunoreactive cells of unreported morphology. SERT was immunohistochemically localized in a very small population of cell clusters or single type I cells (2.8%) immunoreactive for synaptophysin, the ...
Takuya Yokoyama, Sayed Sharif Abdali, Nobuaki Nakamuta, Yoshio Yamamoto   +3 more
wiley   +1 more source

GABAA receptors and neuroligin 2 synergize to promote synaptic adhesion and inhibitory synaptogenesis

Frontiers in Cellular Neuroscience
GABAA receptors (γ-aminobutyric acid-gated receptors type A; GABAARs), the major structural and functional postsynaptic components of inhibitory synapses in the mammalian brain, belong to a family of GABA-gated Cl−/HCO3− ion channels.
Yusheng Sui, Martin Mortensen, Banghao Yuan, Martin W. Nicholson, Trevor G. Smart, Jasmina N. Jovanovic   +5 more
doaj   +1 more source

Learning a Foreign Language in Older Adults Shapes the Functional Connectivity of Distinct Cerebellar Sub‐Regions With Cortical Areas Rich in CB1 Receptor Expression

Brain and Behavior, Volume 15, Issue 5, May 2025.
Learning a foreign language in older adults altered the connectivity of Crus I and Lobule VI with associative and sensory areas, overlapping the distribution of CB1 receptors. ABSTRACT Background Foreign language learning (FLL) in older adults is a comprehensive cognitive enhancement tool that integrates linguistic, cognitive, and social components to ...
Giovanna Bubbico, Federica Tomaiuolo, Carlo Sestieri, Golnoush Akhlaghipour, Alberto Granzotto, Antonio Ferretti, Mauro Gianni Perrucci, Stefano L. Sensi, Stefano Delli Pizzi   +8 more
wiley   +1 more source

Extrasynaptic vesicle recycling in mature hippocampal neurons [PDF]

Nature Communications, 2011
Fast neuronal signalling relies on highly regulated vesicle fusion and recycling at specialized presynaptic terminals. Recently, examples of non-classical neurotransmission have also been reported, where fusion of vesicles can occur at sites remote from conventional synapses.
Ratnayaka, Arjuna, Marra, Vincenzo, Branco, Tiago, Staras, Kevin   +3 more
openaire   +4 more sources

Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area

Frontiers in Neuroscience
Exposure of neurons in the brainstem mesopontine tegmental anesthesia area (MPTA) to minute quantities of GABAergic general anesthetics at clinically relevant concentrations is sufficient to induce loss-of-consciousness (LOC), while lesioning this ...
Angham Ibraheem, Kristina Vaso, Anne Minert, Shai-Lee Yatziv, Mark Baron, Marshall Devor, Marshall Devor   +6 more
doaj   +1 more source

Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity

Glia, Volume 73, Issue 5, Page 1051-1067, May 2025.
Main Points Cocaine and amphetamine stimulates astrocytes and downregulates the GLT‐1. The dysfunction in GLT‐1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant‐treated mice. These effects were restored by upregulation of GLT‐1.
Samuel Alberquilla, Carmen Nanclares, Sara Expósito, Grace Gall, Paulo Kofuji, Alfonso Araque, Eduardo D. Martín, Rosario Moratalla   +7 more
wiley   +1 more source