Results 61 to 70 of about 26,166 (275)

Exocytosis of serotonin from the neuronal soma is sustained by a serotonin and calcium-dependent feedback loop

Frontiers in Cellular Neuroscience, 2014
The soma of many neurons releases large amounts of transmitter molecules through an exocytosis process that continues for hundreds of seconds after the end of the triggering stimulus.
Carolina eLeon-Pinzon, Montserrat G. Cercós, Paula eNoguez, Citlali eTrueta, Francisco eF. De-Miguel   +4 more
doaj   +1 more source

Social experience and sex-dependent regulation of aggression in the lateral septum by extrasynaptic δGABAA receptors

Psychopharmacology, 2019
Johnathan M. Borland, James C. Walton, Alisa Norvelle, Kymberly N. Grantham, Lauren M. Aiani, Tony E. Larkin, Katharine E. McCann, H. Elliott Albers   +7 more
openalex   +3 more sources

GABA_BReceptors Regulate Extrasynaptic GABA_AReceptors [PDF]

The Journal of Neuroscience, 2013
Tonic inhibitory GABAAreceptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells, and cerebellar granule cells. Here we show that in rat brain slices, activation of postsynaptic GABABreceptors enhances the magnitude of the tonic GABAAcurrent ...
Connelly, William, Fyson, Sarah J., Errington, Adam, McCafferty, Cian P., Cope, David W., Di Giovanni, Giuseppe, Crunelli, Vincenzo   +6 more
openaire   +4 more sources

Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks

Frontiers in Physiology, 2012
Extrasynaptic neurotransmission is an important short distance form of volume transmission (VT) and describes the extracellular diffusion of transmitters and modulators after synaptic spillover or extrasynaptic release in the local circuit regions ...
Kjell eFuxe, Dasiel Oscar Borroto-Escuela, Wilber eRomero-Fernandez, Zaida eDiaz Cabiale, Alicia eRivera, Luca eFerraro, Sergio eTanganelli, Alexander O Tarakanov, Pere eGarriga, Jose A. eNarvaez, Francisco eCiruela, Luigi F Agnati   +11 more
doaj   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
A Barberis, A Scimemi, A Tao, A Triller, AE Spruce, AG Ogston, AI Gulyas, AM Aravanis, Annalisa Scimemi, AV Hill, B Barbour, B Ceccarelli, B Granseth, B Katz, C Auger, C Nicholson, C Nicholson, C Nicholson, C Racca, D Colquhoun, D Colquhoun, D Sulzer, DA Rusakov, DE Bergles, DM Kullmann, DR Copenhagen, E Betzig, E Neher, E Sykova, EL Botvinick, EN Pothos, EP Huang, F Asztely, F Pouille, G Brasnjo, G Liu, G Szapiro, G Tong, GH Acheson, GH Patterson, H Korn, H Korn, H Shroff, HC Hartzell, IM Raman, J Balaji, J Castillo Del, J Hrabe, J Matthews-Bellinger, J Szabadics, JC Eccles, JC Eccles, JC Eccles, JD Clements, JE Heuser, JH Singer, JI Wadiche, JI Wadiche, JJ Celentano, JM Bekkers, JM Christie, JM Fernandez, JR Stiles, JS Diamond, JS Diamond, JS Diamond, JW Mozrzymas, JW Mozrzymas, K Belaya, K Krnjevic, K Luby-Phelps, K Zheng, KA Foster, KE Sorra, KL Magleby, KM Franks, KP Lehre, L He, L Tao, LG Longsworth, LM Levy, LM Wahl, LP Savtchenko, LS Overstreet, M Beato, M Beato, M Beato, MA Medina, Marco Beato, MI Banks, MJ Higley, MV Jones, MY Min, N Arnth-Jensen, N Harata, N Riveros, NC Harata, O Prange, P Fatt, P Fatt, P Legendre, PJ Kruk, PM Burger, Q Zhang, Q Zhang, R Ando, R Conti, R Renden, R Ventura, RG Thorne, RH Chow, RM Wightman, RW Daniels, RY Tsien, S Habuchi, S Hrabetova, S Manley, S Namiki, S Okumoto, S Takamori, SA Hires, SJ Pitt, SP Gandhi, SW Kuffler, SY Breusegem, T Lu, T Schikorski, T Schikorski, TA Nielsen, TG Allen, TG Banke, TG Oertner, TM Bartol Jr, V Burzomato, VA Levin, W Almers, W Lu, X Chen, XS Wu, Y Dehnes, Y Takumi, YH Huang, Z Nusser, Z Petrasek, Z Petrasek   +144 more
core   +2 more sources

Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro.

ACS Nano, 2020
N-methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors controlling fundamental physiological processes in the central nervous system, such as learning and memory.
P. Valente, D. Kiryushko, Silvio Sacchetti, P. Machado, C. Cobley, V. Mangini, A. Porter, J. Spatz, R. Fleck, F. Benfenati, R. Fiammengo   +10 more
semanticscholar   +1 more source

Functional characterization of dopamine transporter in vivo using Drosophila melanogaster behavioral analysis.

Frontiers in Behavioral Neuroscience, 2014
Dopamine mediates diverse functions such as motivation, reward, attention, learning/memory and sleep/arousal. Recent studies using model organisms including the fruit fly, have elucidated various physiological functions of dopamine, and identified ...
Taro eUeno, Taro eUeno, Kazuhiko eKume, Kazuhiko eKume   +3 more
doaj   +1 more source

A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction [PDF]

, 2008
Background: The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal ...
Fox, Michael A., Ho, Matthew S.P., Sanes, Joshua R., Smyth, Neil   +3 more
core   +4 more sources

Sevoflurane‐induced overexpression of extrasynaptic α5‐GABAAR via the RhoA/ROCK2 pathway impairs cognitive function in aged mice

Aging Cell
Perioperative neurocognitive disorder (PND) is a serious neurologic complication in aged patients and might be associated with sevoflurane exposure. However, the specific pathogenesis is still unclear. The distribution of α5‐GABAAR, a γ‐aminobutyric acid
Zhun Wang, Jinpeng Dong, Mengxue Zhang, Sixuan Wang, Jiangnan Wu, Shengran Wang, Yuan Luo, Yongan Wang, Yiqing Yin   +8 more
semanticscholar   +1 more source

Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]

, 2014
Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J, Hare, Emma B, Lozano, Reymundo   +2 more
core   +1 more source