Results 61 to 70 of about 12,502 (205)
Natural aminosterols inhibit NMDA receptors with low nanomolar potency
The FEBS Journal, Volume 292, Issue 13, Page 3521-3544, July 2025.Misfunction of N‐methyl‐D‐aspartate (NMDA) receptors is associated with many brain disorders, making them primary targets for drug discovery. Trodusquemine and other natural aminosterols inhibit NMDA receptors with low nanomolar potency through binding to the cell membranes followed by interaction with the channels.
Giulia Fani +9 more
wiley +1 more source
Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons
Scientific Reports, 2017 In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs
Qian Yang +11 more
doaj +1 more source
Insulin Regulates GABAA Receptor-Mediated Tonic Currents in the Prefrontal Cortex
Frontiers in Neuroscience, 2018 Recent studies, have shown that insulin increases extrasynaptic GABAA receptor-mediated currents in the hippocampus, causing alterations of neuronal excitability.
Saraí Trujeque-Ramos +6 more
doaj +1 more source
Journal of Neurochemistry, Volume 169, Issue 7, July 2025.This study highlights the innovative application of multiplexing fast‐scan cyclic voltammetry (FSCV) and genetically encoded fluorescence sensors to simultaneously monitor interactions among adenosine, dopamine, and glutamate with high temporal and spatial resolution.
Kailash Shrestha +3 more
wiley +1 more source
Extrasynaptic vesicle recycling in mature hippocampal neurons [PDF]
Nature Communications, 2011 Fast neuronal signalling relies on highly regulated vesicle fusion and recycling at specialized presynaptic terminals. Recently, examples of non-classical neurotransmission have also been reported, where fusion of vesicles can occur at sites remote from conventional synapses.
Ratnayaka, Arjuna +3 more
openaire +4 more sources
Frontiers in Cellular NeuroscienceGABAA receptors (γ-aminobutyric acid-gated receptors type A; GABAARs), the major structural and functional postsynaptic components of inhibitory synapses in the mammalian brain, belong to a family of GABA-gated Cl−/HCO3− ion channels.
Yusheng Sui +5 more
doaj +1 more source
The FASEB Journal, Volume 39, Issue 11, 15 June 2025.Mutations in the human GABA transporter 1 (hGAT‐1) gene impair GABA transport, leading to developmental disorders like epilepsy and autism. These mutations often disrupt protein folding. Pharmacochaperones can rescue transporter expression and function in heterologous cell lines and in Drosophila melanogaster, thus offering potential therapeutic ...
Nikita Shah +8 more
wiley +1 more source
Synaptic and Extrasynaptic Factors Governing Glutamatergic Retinal Waves [PDF]
Neuron, 2009 In the few days prior to eye-opening in mice, the excitatory drive underlying waves switches from cholinergic to glutamatergic. Here, we describe the unique synaptic and spatiotemporal properties of waves generated by the retina's glutamatergic circuits. First, knockout mice lacking vesicular glutamate transporter type 1 do not have glutamatergic waves,
Marla B. Feller +7 more
openaire +2 more sources
Cell Biology International, Volume 49, Issue 6, Page 659-673, June 2025.ABSTRACT Alzheimer's disease (AD) is prevalent in the elderly population and characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), composed of tau proteins, and extracellular deposition of beta‐amyloid protein (Aβ). The present study aimed to investigate the neuroprotective effects of melatonin on Aβ42‐induced AD‐like ...
Jiraporn Panmanee +11 more
wiley +1 more source
Frontiers in Synaptic Neuroscience, 2019 N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic signaling, and alterations in the synaptic/extrasynaptic NMDAR balance affect neuronal survival.
Rujun Kang +5 more
doaj +1 more source