Results 71 to 80 of about 26,166 (275)

Pathophysiological power of improper tonic GABAA conductances in mature and immature models

Frontiers in Neural Circuits, 2013
High-affinity extrasynaptic gamma-aminobutyric acid A (GABAA) receptors are tonically activated by low and consistent levels of ambient GABA, mediating chronic inhibition against neuronal excitability (tonic inhibition) and the modulation of neural ...
Kiyoshi eEgawa, Atsuo eFukuda
doaj   +1 more source

The Disruption of NMDAR/TRPM4 Death Signaling with TwinF Interface Inhibitors: A New Pharmacological Principle for Neuroprotection

Pharmaceuticals, 2023
With the discovery that the acquisition of toxic features by extrasynaptic NMDA receptors (NMDARs) involves their physical interaction with the non-selective cation channel, TRPM4, it has become possible to develop a new pharmacological principle for ...
Jing Yan, Hilmar Bading
doaj   +1 more source

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA_A receptor-mediated inhibition [PDF]

, 2014
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Alkire, Andrada, Angel, Belelli, Belelli, Belelli, Bonin, Brickley, Chandra, Ching, Cope, Coulter, Farrant, Fiset, Franks, Franks, Gili, Glykys, Hales, Herd, Herd, Hill-Venning, Hofbauer, Huguenard, Iyer, Jensen, Jia, Jia, Jurd, Kasugai, Kralic, Kralic, Kralic, Kralic, Krosigk, McKernan, Mihalek, Olsen, Orser, Peden, Peng, Pistis, Purdon, Reynolds, Rudolph, Rudolph, Steriade, Steriade, Sur, Talavera, Thomson, Tretter, Uchida, Wafford, White, Yang, Ying, Ying   +57 more
core   +3 more sources

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Synaptic and Extrasynaptic Factors Governing Glutamatergic Retinal Waves [PDF]

Neuron, 2009
In the few days prior to eye-opening in mice, the excitatory drive underlying waves switches from cholinergic to glutamatergic. Here, we describe the unique synaptic and spatiotemporal properties of waves generated by the retina's glutamatergic circuits. First, knockout mice lacking vesicular glutamate transporter type 1 do not have glutamatergic waves,
Blankenship, Aaron G., Ford, Kevin J., Johnson, Juliette, Seal, Rebecca P., Edwards, Robert H., Copenhagen, David R., Feller, Marla B.   +6 more
openaire   +2 more sources

Fast detection of extrasynaptic GABA with a whole-cell sniffer

Frontiers in Cellular Neuroscience, 2014
Gamma-amino-butyric acid (GABA) is the main inhibitory transmitter of the brain. It operates by binding to specific receptors located both inside and outside synapses.
Rasmus Kordt Christensen, Anders Victor Petersen, Nicole eSchmitt, Jean-François ePerrier   +3 more
doaj   +1 more source

An in vivo biosensor for neurotransmitter release and in situ receptor activity. [PDF]

, 2010
Tools from molecular biology, combined with in vivo optical imaging techniques, provide new mechanisms for noninvasively observing brain processes. Current approaches primarily probe cell-based variables, such as cytosolic calcium or membrane potential ...
Griesbeck, Oliver, Kleinfeld, David, Mank, Marco, Muller, Arnaud, Nguyen, Quoc-Thang, Schroeder, Lee F, Taylor, Palmer   +6 more
core   +2 more sources

Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations

Journal of Experimental Medicine, 2017
Bading reviews many neurodegenerative diseases sharing heightened extrasynaptic NMDA receptor signaling, which causes a pathological triad with mitochondrial dysfunction, deregulation of transcription, and loss of dendritic structures and connectivity ...
H. Bading
semanticscholar   +1 more source

Tonic GABA‐activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis

Hippocampus, 2020
The hippocampus is a medial temporal lobe structure in the brain and is widely studied for its role in memory and learning, in particular, spacial memory and emotional responses.
O. Netsyk, H. Hammoud, S. Korol, Zhe Jin, Atieh Tafreshiha, B. Birnir   +5 more
semanticscholar   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source