Results 71 to 80 of about 12,419 (203)

Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model

Frontiers in Synaptic Neuroscience, 2019
N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic signaling, and alterations in the synaptic/extrasynaptic NMDAR balance affect neuronal survival.
Rujun Kang, Liang Wang, Shaun S. Sanders, Kurt Zuo, Michael R. Hayden, Lynn A. Raymond   +5 more
doaj   +1 more source

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

Astrocyte Dysfunctions in Obsessive Compulsive Disorder: Rethinking Neurobiology and Therapeutic Targets

Journal of Neurochemistry, Volume 169, Issue 5, May 2025.
This review highlights a paradigm shift in understanding obsessive‐compulsive disorder (OCD), positioning astrocytes as central players rather than passive support cells. Astrocytes crucially regulate neurotransmitter homeostasis, synaptic plasticity, and neural circuit function within the cortico‐striato‐thalamo‐cortical network, disruptions of which ...
Laurine Gonzalez, Paola Bezzi
wiley   +1 more source

Extrasynaptic Release of Serotonin Affects the Social Dynamics of Leeches [PDF]

Frontiers in Physiology, 2012
In order to attain significative advance in almost any area in modern-day scientific research, it is often necessary to think out-of-the-box. That is, if we want to catch something fresh and new, we need to abandon traditional paradigms and preconceived ways of reasoning. In this sense, the paper by Bisson et al.
openaire   +4 more sources

Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons

Frontiers in Physiology, 2012
Persistent peripheral inflammation changes AMPA receptor (AMPAR) trafficking in dorsal horn neurons by promoting internalization of GluR2-containing, Ca2+-impermeable AMPARs from the synapses and by increasing insertion of GluR1-containing, Ca2 ...
Olga eKopach, Viacheslav eViatchenko-Karpinski, Pavel eBelan, Nana eVoitenko   +3 more
doaj   +1 more source

DMV extrasynaptic NMDA receptors regulate caloric intake in rats

JCI Insight, 2021
Acute high-fat diet (aHFD) exposure induces a brief period of hyperphagia before caloric balance is restored. Previous studies have demonstrated that this period of regulation is associated with activation of synaptic N-methyl-D-aspartate (NMDA ...
Courtney Clyburn, R. Alberto Travagli, Amy C. Arnold, Kirsteen N. Browning   +3 more
doaj   +1 more source

Erratum: Corrigendum: Regulating anxiety with extrasynaptic inhibition [PDF]

Nature Neuroscience, 2015
Nat. Neurosci. 18, 1493–1500 (2015); published online 31 August 2015; corrected after print 5 October 2015 In the version of this article initially published, the grant number for U.R. was given as R01MH80006 instead of R01MH080006 and grants to J.M.C.
Paolo Botta, Lynda Demmou, Yu Kasugai, Milica Marković, Chun Xu, Jonathan P. Fadok, Ting‐Jia Lu, Michael M. Poe, Xu Li, James M. Cook, Uwe Rudolph, Pankaj Sah, Francesco Ferraguti, Andreas Lüthi   +13 more
openalex   +4 more sources

Dendritic signaling in inhibitory interneurons: local tuning via group I metabotropic glutamate receptors

Frontiers in Physiology, 2012
Communication between neurons is achieved by rapid signal transduction via highly specialized structural elements known as synaptic contacts. In addition, numerous extrasynaptic mechanisms provide a flexible platform for the local regulation of synaptic ...
Olivier eCamiré, Jean-Claude eLacaille, Lisa eTopolnik   +2 more
doaj   +1 more source

Running Reverses Chronic Stress‐Induced Changes in Serotonergic Modulation of Hippocampal Granule Cells and Altered Behavioural Responses

European Journal of Neuroscience, Volume 61, Issue 7, April 2025.
Chronic stress restraint (CRS) induces altered behavioural responses that are mitigated by running treatment. We evaluated serotonergic modulation of hippocampal granule cells (GC) excitability, as a potential mechanism underlying exercise‐induced anxiolytic and antidepressive effects.
Carmen Soto, Lazaro P. Orihuela, Grego Apostol, Carmen Vivar   +3 more
wiley   +1 more source

Extrasynaptic glutamate receptor activation as cellular bases for dynamic range compression in pyramidal neurons

Frontiers in Physiology, 2012
Repetitive synaptic stimulation overcomes the ability of astrocytic processes to clear glutamate from the extracellular space, allowing some dendritic segments to become submerged in a pool of glutamate.
Katerina D Oikonomou, Shaina M Short, Matthew T Rich, Srdjan D Antic   +3 more
doaj   +1 more source