Results 71 to 80 of about 12,502 (205)

DMV extrasynaptic NMDA receptors regulate caloric intake in rats

JCI Insight, 2021
Acute high-fat diet (aHFD) exposure induces a brief period of hyperphagia before caloric balance is restored. Previous studies have demonstrated that this period of regulation is associated with activation of synaptic N-methyl-D-aspartate (NMDA ...
Courtney Clyburn, R. Alberto Travagli, Amy C. Arnold, Kirsteen N. Browning   +3 more
doaj   +1 more source

Membrane progesterone and oestrogen receptors modulate GABAergic transmission in the prefrontal cortex of prepubertal male, but not female, mice

Experimental Physiology, Volume 110, Issue 6, Page 888-898, 1 June 2025.
Abstract The sex hormones progesterone (P) and oestrogen (E) reorganize GABAergic transmission in the prefrontal cortex (PFC) during the transition from childhood to adolescence, generating a new excitatory–inhibitory balance necessary for the computational capacity of the mature PFC.
Aitana Vázquez‐Sola, Hortensia Torres‐Torrelo, Josué García Yagüe   +2 more
wiley   +1 more source

Extrasynaptic Release of Serotonin Affects the Social Dynamics of Leeches [PDF]

Frontiers in Physiology, 2012
In order to attain significative advance in almost any area in modern-day scientific research, it is often necessary to think out-of-the-box. That is, if we want to catch something fresh and new, we need to abandon traditional paradigms and preconceived ways of reasoning. In this sense, the paper by Bisson et al.
openaire   +4 more sources

Meprin β Modulates Brevican Proteolysis Impairing Neural Plasticity and Memory Formation

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
Meprin β was studied using mice overexpressing it in cortical and hippocampal neurons. N‐terminomics identified brevican, a key extracellular matrix protein associated with synaptic plasticity and memory, as a potential substrate of meprin β. Further analyses revealed that brevican levels are dependent on the catalytic activity of meprin β.
Maximilian Keller, Celine Gallagher, Simon Kreiselmaier, Kira Bickenbach, Ulrich Schmitt, Liana Marengo, Dayan Taghikhah, Mohammad Abukhalaf, Andreas Tholey, Christoph Becker‐Pauly, Thomas Mittmann, Claus U. Pietrzik   +11 more
wiley   +1 more source

Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons

Frontiers in Physiology, 2012
Persistent peripheral inflammation changes AMPA receptor (AMPAR) trafficking in dorsal horn neurons by promoting internalization of GluR2-containing, Ca2+-impermeable AMPARs from the synapses and by increasing insertion of GluR1-containing, Ca2 ...
Olga eKopach, Viacheslav eViatchenko-Karpinski, Pavel eBelan, Nana eVoitenko   +3 more
doaj   +1 more source

Sodium Oxybate‐Treated Familial Myoclonus‐Dystonia Syndrome Due to Novel SGCE Variant

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Myoclonus‐dystonia syndrome (MDS, OMIM #159900) is an autosomal‐dominant movement disorder caused by heterozygous variants in the epsilon sarcoglycan gene (SGCE) and characterized by a combination of myoclonic jerks, dystonia, and psychiatric comorbidities.
Malak Ali Alghamdi, Muddathir H. Hamad, Isra Alghamdi, Ghiada Alghamdi, Muneera Al‐Jelaify, Sohaila Alshimemeri, Hebattalah Hamed, Nouran Adly, Mustafa A. Salih, Naif A. Almontashiri, Fahad A. Bashiri   +10 more
wiley   +1 more source

Dendritic signaling in inhibitory interneurons: local tuning via group I metabotropic glutamate receptors

Frontiers in Physiology, 2012
Communication between neurons is achieved by rapid signal transduction via highly specialized structural elements known as synaptic contacts. In addition, numerous extrasynaptic mechanisms provide a flexible platform for the local regulation of synaptic ...
Olivier eCamiré, Jean-Claude eLacaille, Lisa eTopolnik   +2 more
doaj   +1 more source

Distribution and morphology of serotonin transporter‐immunoreactive type I cells in the rat carotid body

The Anatomical Record, Volume 308, Issue 5, Page 1504-1516, May 2025.
Abstract The present study reexamined the immunolocalization of membranous serotonin transporter (SERT) in the rat carotid body, and demonstrated SERT‐immunoreactive cells of unreported morphology. SERT was immunohistochemically localized in a very small population of cell clusters or single type I cells (2.8%) immunoreactive for synaptophysin, the ...
Takuya Yokoyama, Sayed Sharif Abdali, Nobuaki Nakamuta, Yoshio Yamamoto   +3 more
wiley   +1 more source

Extrasynaptic glutamate receptor activation as cellular bases for dynamic range compression in pyramidal neurons

Frontiers in Physiology, 2012
Repetitive synaptic stimulation overcomes the ability of astrocytic processes to clear glutamate from the extracellular space, allowing some dendritic segments to become submerged in a pool of glutamate.
Katerina D Oikonomou, Shaina M Short, Matthew T Rich, Srdjan D Antic   +3 more
doaj   +1 more source

Extrasynaptic GABAA receptors in the crosshairs of hormones and ethanol [PDF]

Neurochemistry International, 2008
Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system (CNS) it acts on two distinct types of receptor: an ion channel, i.e., an "ionotropic" receptor permeable to Cl- and HCO3- (GABAA receptors) and a G-protein coupled "metabotropic" receptor that is linked to various effector ...
openaire   +3 more sources