Results 81 to 90 of about 23,129 (240)

Glutamate Delta 1 Receptor in Synapses, Circuits, and Disease

European Journal of Neuroscience, Volume 63, Issue 3, February 2026.
This review discusses our current understanding of the structure–function, expression and roles in neural circuits of the less studied glutamate delta 1 (GluD1) receptor. Converging data suggests many unique features of GluD1 including expression at both excitatory and inhibitory synapses and binding to D‐serine and GABA.
Diane Choi, Poojashree B. Chettiar, Yoland Smith, Shashank M. Dravid   +3 more
wiley   +1 more source

Loss-of-consciousness: sources of GABAergic input to the mesopontine tegmental anesthesia area

Frontiers in Neuroscience
Exposure of neurons in the brainstem mesopontine tegmental anesthesia area (MPTA) to minute quantities of GABAergic general anesthetics at clinically relevant concentrations is sufficient to induce loss-of-consciousness (LOC), while lesioning this ...
Angham Ibraheem, Kristina Vaso, Anne Minert, Shai-Lee Yatziv, Mark Baron, Marshall Devor, Marshall Devor   +6 more
doaj   +1 more source

In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death [PDF]

, 2009
It has been suggested that NR2B-containing N-methyl-d-aspartate (NMDA) receptors have a selective tendency to promote pro-death signaling and synaptic depression, compared with the survival promoting, synapse potentiating properties of NR2A-containing ...
Hardingham, G.E., Martel, M.-A., Wyllie, D.J.A.   +2 more
core   +1 more source

Junctional conductance of retinal AII amacrine cell electrical synapses is decreased by NMDA receptors

The Journal of Physiology, Volume 604, Issue 3, Page 1373-1390, 1 February 2026.
Abstract figure legend AII amacrine cells are an important class of interneuron in the vertebrate retina. In addition to traditional chemical synapses these cells communicate with other neurons and with each other via electrical synapses. (A) Electrical synapse strength between AII amacrine cells was measured using dual whole‐cell patch‐clamp ...
Chloe Cable, Sidney P. Kuo, Eric A. Newman   +2 more
wiley   +1 more source

Extrasynaptic site of action for γ-hydroxybutyrate [PDF]

Proceedings of the National Academy of Sciences, 2012
Advances in pharmacology often result from identifying the mechanism of action of drugs found empirically to be biologically active (1). γ-Hydroxybutyric acid (GHB), also known as Fantasy, is a centrally active agent that has been used clinically and recreationally for nearly half a century.
openaire   +2 more sources

Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes

eLife, 2017
Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and ...
Sang Hak Lee, Chaoyi Jin, En Cai, Pinghua Ge, Yuji Ishitsuka, Kai Wen Teng, Andre A de Thomaz, Duncan Nall, Murat Baday, Okunola Jeyifous, Daniel Demonte, Christopher M Dundas, Sheldon Park, Jary Y Delgado, William N Green, Paul R Selvin   +15 more
doaj   +1 more source

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Mary Heng, Peter Detloff, Phillip Wang, Roger Albin   +4 more
core   +1 more source

Photo-antagonism of the GABAA receptor [PDF]

, 2014
Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
A Sali, A Triller, B Frolund, C Notredame, CG Wermuth, CL Padgett, CM Houston, D Belelli, DA Wagner, DM Kullmann, E Sigel, EF Pettersen, EG Steward, EM Schneider Gasser, EO Mann, F Iqbal, G Jones, G Nyiri, H Kiefer, H Mohler, H Zhong, J Amin, J Isaacson, JG Newell, JG Newell, JH Holden, JJ Chambers, JM Fritschy, JQ Kang, JT Kittler, K Ramamoorthi, L Dubinsky, LB Kier, M Ernst, M Heaulme, M Mortensen, M Mortensen, M Mortensen, M Mortensen, MA Simmonds, MC Ashby, N Zacharias, NG Bowery, O Arunlakshana, P Thomas, PS Miller, R Sathyapriya, RW Olsen, S Ueno, SB Hansen, SC Lummis, SE Westh-Hansen, SE Westh-Hansen, SJ Moss, T Klausberger, T Klausberger, TC Turek, U Resch-Genger, Y Bogdanov, Y Chang   +59 more
core   +1 more source

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
wiley   +1 more source

FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]

, 2014
The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca, Liu, Xiaoqian, Lobner, Doug   +2 more
core   +1 more source