Results 11 to 20 of about 622,719 (265)

Actin structure-dependent stepping of myosin 5a and 10 during processive movement. [PDF]

PLoS ONE, 2013
How myosin 10, an unconventional myosin, walks processively along actin is still controversial. Here, we used single molecule fluorescence techniques, TIRF and FIONA, to study the motility and the stepping mechanism of dimerized myosin 10 heavy ...
Jianjun Bao, Daniel Huck, Laura K Gunther, James R Sellers, Takeshi Sakamoto   +4 more
doaj   +1 more source

Investigation of the Potential Mechanisms Underlying Nuclear F-Actin Organization in Ovarian Cancer Cells by High-Throughput Screening in Combination With Deep Learning

Frontiers in Cell and Developmental Biology, 2022
Increasing evidence supports the notion that filamentous actin (F-actin) and globular actin exist in the nuclei of somatic cells, and are involved in chromatin remodeling, gene transcription regulation and DNA damage repair.
Wei Wu, Xiaoxia Xing, Mingyang Wang, Yinzhou Feng, Nina Wietek, Nina Wietek, Kay Chong, Kay Chong, Salma El-Sahhar, Salma El-Sahhar, Ahmed Ashour Ahmed, Ahmed Ashour Ahmed, Rongyu Zang, Yiyan Zheng   +13 more
doaj   +1 more source

Formin-2 drives polymerisation of actin filaments enabling segregation of apicoplasts and cytokinesis in Plasmodium falciparum

eLife, 2019
In addition to its role in erythrocyte invasion, Plasmodium falciparum actin is implicated in endocytosis, cytokinesis and inheritance of the chloroplast-like organelle called the apicoplast.
Johannes Felix Stortz, Mario Del Rosario, Mirko Singer, Jonathan M Wilkes, Markus Meissner, Sujaan Das   +5 more
doaj   +1 more source

Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1. [PDF]

PLoS ONE, 2015
The dynamic assembly of filamentous (F) actin plays essential roles in the assembly of presynaptic boutons, the fusion, mobilization and recycling of synaptic vesicles (SVs), and presynaptic forms of plasticity.
Dhananjay Wagh, Ryan Terry-Lorenzo, Clarissa L Waites, Sergio A Leal-Ortiz, Christoph Maas, Richard J Reimer, Craig C Garner   +6 more
doaj   +1 more source

Multiple Roles of Actin in Exo- and Endocytosis

Frontiers in Synaptic Neuroscience, 2022
Cytoskeletal filamentous actin (F-actin) has long been considered a molecule that may regulate exo- and endocytosis. However, its exact roles remained elusive.
Ling-Gang Wu, Chung Yu Chan
doaj   +1 more source

Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast

eLife, 2019
We previously discovered that competition between fission yeast actin binding proteins (ABPs) for binding F-actin facilitates their sorting to different cellular networks.
Jenna R Christensen, Kaitlin E Homa, Alisha N Morganthaler, Rachel R Brown, Cristian Suarez, Alyssa J Harker, Meghan E O'Connell, David R Kovar   +7 more
doaj   +1 more source

Sensing Actin Dynamics through Adherens Junctions

Cell Reports, 2020
Summary: We study punctate adherens junctions (pAJs) to determine how short-lived cadherin clusters and relatively stable actin bundles interact despite differences in dynamics.
Indrajyoti Indra, Regina B. Troyanovsky, Lawrence Shapiro, Barry Honig, Sergey M. Troyanovsky   +4 more
doaj   +1 more source

Actin depolymerizing factor ADF7 inhibits actin bundling protein VILLIN1 to regulate root hair formation in response to osmotic stress in Arabidopsis.

PLoS Genetics, 2022
Actin cytoskeleton is essential for root hair formation. However, the underlying molecular mechanisms of actin dynamics in root hair formation in response to abiotic stress are largely undiscovered. Here, genetic analysis showed that actin-depolymerizing
Shuangtian Bi, Mingyang Li, Caiyuan Liu, Xiaoyu Liu, Jianing Cheng, Lu Wang, Jinshu Wang, Yanling Lv, Ming He, Xin Cheng, Yue Gao, Che Wang   +11 more
doaj   +1 more source

Multiple Conformations of F-actin [PDF]

Structure, 2010
Actin works within eukaryotic cells to facilitate a variety of cellular processes, which are driven by the assembly of G-actin (monomeric form) into F-actin (fibrous form), and the disassembly of F-actin into G-actin. F-actin adopts multiple conformations, which are specified by interactions with various actin-binding proteins.
Oda, Toshiro, Maéda, Yuichiro
openaire   +2 more sources

Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks

eLife, 2017
The fission yeast actin cytoskeleton is an ideal, simplified system to investigate fundamental mechanisms behind cellular self-organization. By focusing on the stabilizing protein tropomyosin Cdc8, bundling protein fimbrin Fim1, and severing protein ...
Jenna R Christensen, Glen M Hocky, Kaitlin E Homa, Alisha N Morganthaler, Sarah E Hitchcock-DeGregori, Gregory A Voth, David R Kovar   +6 more
doaj   +1 more source