Results 91 to 100 of about 13,969 (210)

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Fatty Acid Amide Hydrolase (FAAH) is a serine hydrolase that plays a key role in controlling endogenous levels of endocannabinoids. FAAH inhibition is considered a powerful approach to enhance the endocannabinoid signalling, and therefore it has been ...
Alessandro Deplano, Mariateresa Cipriano, Federica Moraca, Ettore Novellino, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis   +6 more
doaj   +1 more source

Subcellular localization and tissue specific expression of amidase 1 from Arabidopsis thaliana [PDF]

, 2006
Amidase 1 (AMI1) from Arabidopsis thaliana converts indole-3-acetamide (IAM), into indole-3-acetic acid (IAA). AMI1 is part of a small isogene family comprising seven members in A.
A Müller, A Müller, A Vojta, A Wachter, AM Metz, AW Woodward, BA Stelmach, BF Cravatt, Daniel Neu, DE Saslowsky, DK Giang, E Kemper, Elmar W. Weiler, EW Weiler, FA Ausubel, H Towbin, J Haseloff, J Sambrook, J-F Mayaux, JJ Finer, K Sohrt, KD Scharf, M Kawaguchi, M Kawaguchi, M Kobayashi, M Madera, M Saotome, MH Bracey, MM Bradford, MP Patricelli, NM Upadhyaya, NR Hofmann, O Chew, O Kleiner, Oliver Berkowitz, R Shrestha, R Shrestha, S Brenner, S Pollmann, S Pollmann, S Shin, S Shin, S Vorwerk, SR Cutler, Stephan Pollmann, T Murashige, Thomas Lehmann, Tina Schäfer, VS Reddy, WB Bruce, Y Arai, YJ Lee, YQ An, YS Kim   +53 more
core   +2 more sources

Evaluating Fatty Acid Amide Hydrolase as a Suitable Target for Sleep Promotion in a Transgenic TauP301S Mouse Model of Neurodegeneration

Pharmaceuticals
Sleep disruption is an expected component of aging and neurodegenerative conditions, including Alzheimer’s disease (AD). Sleep disruption has been demonstrated as a driver of AD pathology and cognitive decline.
Shenée C. Martin, Kathryn K. Joyce, Kathryn M. Harper, Samuel J. Harp, Todd J. Cohen, Sheryl S. Moy, Graham H. Diering   +6 more
doaj   +1 more source

Update of the statement on safety of cannabidiol as a novel food

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract During the assessment of cannabidiol (CBD) as a novel food, in 2022 the NDA Panel identified significant data gaps. Concerns focused on potential adverse effects on the liver, gastrointestinal tract, endocrine, nervous and reproductive systems.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Francesco Cubadda, Helle Katrine Knutsen, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Josef Rudolf Schlatter, Alexandros Siskos, Viviana Trezza, Océane Albert, Elisa Beneventi, Irene Nuin Garciarena, George E. N. Kass, Marcello Laganaro, Annamaria Rossi, Alejandra Muñoz, Areti Favata, Anna Maria Pieger, Maura Magani, Karen Ildico Hirsch‐Ernst   +33 more
wiley   +1 more source

Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity

BMC Medical Genetics, 2010
Background The orexigenic effects of cannabinoids are limited by activation of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH).
Rief Winfried, Scherag Susann, Vogel Carla IG, Grallert Harald, Scherag André, Greene Brandon H, Nguyen Trang T, Carrie Jophia, Wandolski Melanie, Brönner Günter, Müller Timo D, Wichmann Hans-Erich, Illig Thomas, Schäfer Helmut, Hebebrand Johannes, Hinney Anke   +15 more
doaj   +1 more source

Dysregulation of the endocannabinoid signaling system in the cerebellum and brainstem in a transgenic mouse model of spinocerebellar ataxia type-3. [PDF]

, 2016
Spinocerebellar ataxia type-3 (SCA-3) is a rare disease but it is the most frequent type within the autosomal dominant inherited ataxias. The disease lacks an effective treatment to alleviate major symptoms and to modify disease progression.
Fernández Ruiz, José Javier, García García, Luis, García-García, Luis, Gómez Ruiz, María Sagrario, Hernández-Gálvez, Mariluz, Hillard, Cecilia J., Maciel, Patricia, Pozo García, Miguel Ángel, Ramos Atance, José Antonio, Rodríguez Cueto, Carmen Aurora, Valdeolivas, Sara   +10 more
core   +1 more source

Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise

Lipids in Health and Disease, 2011
Background Alterations of endocannabinoid system in adipose tissue play an important role in lipid regulation and metabolic dysfunction associated with obesity. The purpose of this study was to determine whether gene expression levels of cannabinoid type
Yang Rongze, Wang Xuewen, Disanzo Beth L, You Tongjian, Gong Dawei   +4 more
doaj   +1 more source

Genetic variation in the endocannabinoid system and response to cognitive behavioural therapy for child anxiety disorders [PDF]

, 2016
Extinction learning is an important mechanism in the successful psychological treatment of anxiety. Individual differences in response and relapse following Cognitive Behavior Therapy may in part be explained by variability in the ease with which fears ...
Bogels, Susan, Breen, Gerome, Coleman, Jonathan R. I., Creswell, Cathy, Eley, Thalia C., Hudson, Jennifer L., Keers, Robert, Lester, Kathryn J., McKinnon, Anna, Nauta, Maaike, Rapee, Ronald M., Roberts, Susanna, Schneider, Silvia, Silverman, Wendy K., Thastum, Mikael, Waite, Polly, Wergeland, Gro Janne H.   +16 more
core   +4 more sources

Evolution of massive binary black holes [PDF]

, 2001
Since many or most galaxies have central massive black holes (BHs), mergers of galaxies can form massive binary black holes (BBHs). In this paper, we study the evolution of massive BBHs in realistic galaxy models, using a generalization of techniques ...
Yu, Qingjuan
core   +3 more sources

N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with an ...
Naresh Sunduru, Mona Svensson, Mariateresa Cipriano, Sania Marwaha, C. David Andersson, Richard Svensson, Christopher J. Fowler, Mikael Elofsson   +7 more
doaj   +1 more source