Results 11 to 20 of about 356 (134)

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation [PDF]

Frontiers in Immunology, 2017
Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi, Ádám I. Csincsi, Zoltán Mezei, Anne Kopp, Mario Hebecker, Barbara Uzonyi, Mihály Józsi   +6 more
doaj   +6 more sources

Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children [PDF]

Frontiers in Immunology, 2018
Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation.
Anna E. van Beek, Anna E. van Beek, Angela Kamp, Simone Kruithof, Ed J. Nieuwenhuys, Diana Wouters, Ilse Jongerius, Theo Rispens, Taco W. Kuijpers, Taco W. Kuijpers, Kyra A. Gelderman   +10 more
doaj   +4 more sources

Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family [PDF]

Journal of Innate Immunity
Introduction: The alternative pathway of complement activation is consistently active, keeping the complement system primed for immediate response.
Bert R.J. Veuskens, Mara van Rossum, Emi Cattenstart, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Karin van Leeuwen, Jin Liu, Robert A. Anstadt, Burt T. Richards, Gregory S. Hageman, Taco W. Kuijpers, Erik J.M. Toonen, Richard B. Pouw   +13 more
doaj   +3 more sources

Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis [PDF]

Frontiers in Immunology, 2022
Neisseria meningitidis, the causative agent of meningococcal disease (MD), evades complement-mediated clearance upon infection by ‘hijacking’ the human complement regulator factor H (FH).
Anna E. van Beek, Anna E. van Beek, Richard B. Pouw, Richard B. Pouw, Victoria J. Wright, Neneh Sallah, David Inwald, Clive Hoggart, Mieke C. Brouwer, Rachel Galassini, John Thomas, Leo Calvo-Bado, Colin G. Fink, Ilse Jongerius, Ilse Jongerius, Martin Hibberd, Diana Wouters, Michael Levin, Taco W. Kuijpers, Taco W. Kuijpers   +19 more
doaj   +4 more sources

Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation [PDF]

Scientific Reports
Factor H (FH) is a negative regulator of the alternative pathway (AP) of complement however, five human factor H-related (FHR) proteins, can also function ex vivo as positive regulators.
Nirmal K. Banda, Larry W. Moreland, Kevin D. Deane, Dmitri Simberg, Robert I. Scheinman, Rachel M. Frank, Jennifer A. Seifert, Accelerating Medicines Partnership (AMP) RA/SLE Network, Rachel Lau, Costantino Pitzalis, Myles J. Lewis, V. Michael Holers   +11 more
doaj   +3 more sources

Factor H-related protein 1 promotes complement-mediated opsonization of Pseudomonas aeruginosa [PDF]

Frontiers in Cellular and Infection Microbiology
Pseudomonas aeruginosa is an important human opportunistic pathogen responsible for a wide range of infections. The complement system is the main early host defense mechanism to control these infections. P.
Alex González-Alsina, Héctor Martín-Merinero, Margalida Mateu-Borrás, María Verd, Antonio Doménech-Sánchez, Joanna B. Goldberg, Santiago Rodríguez de Córdoba, Sebastián Albertí   +7 more
doaj   +3 more sources

Factor H related proteins modulate complement activation on kidney cells [PDF]

Kidney International, 2022
Complement activation at a particular location is determined by the balance of activating and inhibitory proteins. Factor H is a key regulator of the alternative pathway of complement, and genetic or acquired impairments in Factor H are associated with ...
Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM.   +12 more
exaly   +4 more sources

Contribution of functional and quantitative genetic variants of Complement Factor H and Factor H-Related (FHR) proteins on renal pathology

Nefrología (English Edition), 2022
The complement system is a first line of defence against infectious, tumoral or autoimmune processes, and it is constitutively regulated to avoid excessive or unspecific activation. Factor H (FH), a most relevant complement regulator, controls complement
Irene Gómez Delgado, Pilar Sánchez-Corral   +1 more
doaj   +5 more sources

The Impact of Complement Factor H-Related Protein Gene Deletions on Kidney Transplantation. [PDF]

Scand J Immunol
In this study, we found that rs7542235 allele G tags a deletion of the CFHR1 gene. We also found that rs6677604 allele A tags a deletion of the whole CFHR3–1 locus. The plasma proteomics studies show that both variants are associated with an altered expression of FH/FHR proteins thus revealing a novel level of intricate regulation of the complement ...
Markkinen S, Lokki AI, Helanterä I, Ritari J, Partanen J, Meri S, Hyvärinen K.   +6 more
europepmc   +2 more sources

Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4 [PDF]

Frontiers in Immunology, 2018
Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are hypothesized to act as antagonists of the important complement regulator factor H (FH), fine-tuning complement regulation on human
Richard B. Pouw, Richard B. Pouw, Mieke C. Brouwer, Anna E. van Beek, Anna E. van Beek, Mihály Józsi, Diana Wouters, Taco W. Kuijpers, Taco W. Kuijpers   +8 more
doaj   +3 more sources