Results 21 to 30 of about 356 (134)

Navigating infection by pathogenic spirochetes: The host-bacteria interface at the atomic level. [PDF]

Protein Sci
Abstract Pathogenic spirochetes bind and interact with various host structures and molecules throughout the course of infection. By utilizing their outer surface molecules, spirochetes can effectively modulate their dissemination, interact with immune system regulators, and select specific destination niches within the host.
Hejduk L, Müller N, Rathner A, Štěrba J, Hung SC, Chyan CL, Rego ROM, Strnad M.   +7 more
europepmc   +2 more sources

Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3. [PDF]

PLoS ONE, 2016
The major human complement regulator in blood, complement factor H (FH), has several closely related proteins, called FH-related (FHR) proteins. As all FHRs lack relevant complement regulatory activity, their physiological role is not well understood ...
Richard B Pouw, Mieke C Brouwer, Judy Geissler, Laurens V van Herpen, Sacha S Zeerleder, Walter A Wuillemin, Diana Wouters, Taco W Kuijpers   +7 more
doaj   +2 more sources

Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma [PDF]

Frontiers in Immunology, 2017
The complement factor H-related (FHR) proteins are hypothesized to fine-tune the regulatory role of complement factor H (FH) in the alternative pathway of the complement system.
Anna E. van Beek, Anna E. van Beek, Richard B. Pouw, Richard B. Pouw, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Pleuni Ooijevaar-de Heer, Martin de Boer, Karin van Leeuwen, Theo Rispens, Diana Wouters, Taco W. Kuijpers, Taco W. Kuijpers   +13 more
doaj   +2 more sources

Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors [PDF]

Frontiers in Plant Science, 2019
The human complement system is an important part of the immune system responsible for lysis and elimination of invading microorganisms and apoptotic body cells.
Oguz Top, Oguz Top, Juliana Parsons, Lennard L. Bohlender, Stefan Michelfelder, Phillipp Kopp, Christian Busch-Steenberg, Sebastian N. W. Hoernstein, Peter F. Zipfel, Karsten Häffner, Ralf Reski, Ralf Reski, Ralf Reski, Eva L. Decker   +13 more
doaj   +2 more sources

Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease [PDF]

Scientific Reports, 2021
AbstractAtherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellular necrosis, and complement activation, resulting in inflammation and thrombosis.
Irmscher, S., Zipfel, S., Halder, L., Ivanov, L., Gonzalez-Delgado, A., Waldeyer, C., Seiffert, M., Brunner, F., von der Heide, M., Loeschmann, I., Wulf, S., Czamara, D. ; https://orcid.org/0000-0001-7381-904X, Papac-Milicevic, N., Strauss, O., Lorkowski, S., Reichenspurner, H., Holers V, M., Banda, N., Zeller, T., Binder, E. ; https://orcid.org/0000-0001-7088-6618, Binder, C., Wiech, T., Zipfel, P., Skerka, C.   +23 more
openaire   +4 more sources

FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene [PDF]

European Journal of Human Genetics, 2004
We describe a new member of the human Factor H protein family, termed Factor H-related protein 4A (FHR-4A). The corresponding cDNA sequence was isolated and encodes a secreted protein of 559 amino acids, with a predicted molecular weight of 63.2 kDa. Apparently, this novel cDNA is derived from the human FHR-4 gene. Genetic analysis shows that the human
Mihály, Józsi, Heiko, Richter, Ina, Löschmann, Christine, Skerka, Friedrich, Buck, Ulrike, Beisiegel, Anna, Erdei, Peter F, Zipfel   +7 more
openaire   +2 more sources

CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome

Frontiers in Immunology, 2023
IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare disease that manifests with microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure, and is associated with dysregulation of the alternative complement pathway.
Rossella Piras, Elisabetta Valoti, Marta Alberti, Elena Bresin, Caterina Mele, Matteo Breno, Lucia Liguori, Roberta Donadelli, Miriam Rigoldi, Ariela Benigni, Giuseppe Remuzzi, Marina Noris   +11 more
doaj   +1 more source

Functional properties of complement factor H‐related proteins FHR‐3 and FHR‐4: binding to the C3d region of C3b and differential regulation by heparin [PDF]

FEBS Letters, 1999
The human factor H‐related proteins FHR‐3 and FHR‐4 are members of a family of proteins related to the complement factor H. Here, we report that the two proteins bind to the C3d region of complement C3b. The apparent K A values for the interactions of FHR‐3 and FHR‐4 with C3b are 7.5×106 M−1 and 2.9×106 M−1, respectively. Binding studies performed with
Hellwage, Jens, Jokiranta, T.Sakari, Koistinen, Vesa, Vaarala, Outi, Meri, Seppo, Zipfel, Peter F.   +5 more
openaire   +2 more sources

CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Frontiers in Genetics, 2021
C3 Glomerulopathy (C3G) and Immune Complex-Mediated Membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases characterized by glomerular deposition of C3 caused by dysregulation of the alternative pathway (AP) of complement.
Rossella Piras, Matteo Breno, Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Caterina Mele, Elena Bresin, Roberta Donadelli, Paola Cuccarolo, Richard J. H. Smith, Ariela Benigni, Giuseppe Remuzzi, Marina Noris   +12 more
doaj   +1 more source

Image_4_Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.tiff

, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Cansu Yanginlar (11288481), Mark de Graaf (11288490), Toin H. van Kuppevelt (10013111), Markus A. Loeven (3368984), Richard J. H. Smith (10957842), Marissa L. Maciej-Hulme (5508479), Johan van der Vlag (45996), Edwin Kellenbach (11288487), Jack Wetzels (4542142), Ton J. Rabelink (8695392), Melanie C. Hubers (11288484)   +10 more
core   +1 more source