Results 31 to 40 of about 356 (134)

Image_5_Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.tiff

, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Cansu Yanginlar (11288481), Mark de Graaf (11288490), Toin H. van Kuppevelt (10013111), Markus A. Loeven (3368984), Richard J. H. Smith (10957842), Marissa L. Maciej-Hulme (5508479), Johan van der Vlag (45996), Edwin Kellenbach (11288487), Jack Wetzels (4542142), Ton J. Rabelink (8695392), Melanie C. Hubers (11288484)   +10 more
core   +1 more source

DataSheet_1_Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.docx

, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Cansu Yanginlar (11288481), Mark de Graaf (11288490), Toin H. van Kuppevelt (10013111), Markus A. Loeven (3368984), Richard J. H. Smith (10957842), Marissa L. Maciej-Hulme (5508479), Johan van der Vlag (45996), Edwin Kellenbach (11288487), Jack Wetzels (4542142), Ton J. Rabelink (8695392), Melanie C. Hubers (11288484)   +10 more
core   +1 more source

Image_1_Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.tiff

, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Cansu Yanginlar (11288481), Mark de Graaf (11288490), Toin H. van Kuppevelt (10013111), Markus A. Loeven (3368984), Richard J. H. Smith (10957842), Marissa L. Maciej-Hulme (5508479), Johan van der Vlag (45996), Edwin Kellenbach (11288487), Jack Wetzels (4542142), Ton J. Rabelink (8695392), Melanie C. Hubers (11288484)   +10 more
core   +1 more source

Image_2_Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.tiff

, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Cansu Yanginlar (11288481), Mark de Graaf (11288490), Toin H. van Kuppevelt (10013111), Markus A. Loeven (3368984), Richard J. H. Smith (10957842), Marissa L. Maciej-Hulme (5508479), Johan van der Vlag (45996), Edwin Kellenbach (11288487), Jack Wetzels (4542142), Ton J. Rabelink (8695392), Melanie C. Hubers (11288484)   +10 more
core   +1 more source

Image_3_Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.pdf

, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Cansu Yanginlar (11288481), Mark de Graaf (11288490), Toin H. van Kuppevelt (10013111), Markus A. Loeven (3368984), Richard J. H. Smith (10957842), Marissa L. Maciej-Hulme (5508479), Johan van der Vlag (45996), Edwin Kellenbach (11288487), Jack Wetzels (4542142), Ton J. Rabelink (8695392), Melanie C. Hubers (11288484)   +10 more
core   +1 more source

Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization

Frontiers in Immunology, 2020
Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and
Éva Kárpáti, Alexandra Papp, Andrea E. Schneider, Dávid Hajnal, Marcell Cserhalmi, Ádám I. Csincsi, Barbara Uzonyi, Barbara Uzonyi, Mihály Józsi, Mihály Józsi   +9 more
doaj   +1 more source

Image_6_Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.pdf

, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Cansu Yanginlar (11288481), Mark de Graaf (11288490), Toin H. van Kuppevelt (10013111), Markus A. Loeven (3368984), Richard J. H. Smith (10957842), Marissa L. Maciej-Hulme (5508479), Johan van der Vlag (45996), Edwin Kellenbach (11288487), Jack Wetzels (4542142), Ton J. Rabelink (8695392), Melanie C. Hubers (11288484)   +10 more
core   +1 more source

Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in AMD

, 2020
Background: Age-related macular degeneration (AMD) is a leading cause of blindness. Genetic studies reported strong associations at the CFH locus, with 8 independent signals across KCNT2, CFH, and CFHR1-5. How these variants impact protein expression and function remains to be disentangled. Recently,[for full text, please go to the a.m. URL]
Lorés de Motta, LL, Cipriani, V, He, F, Fathalla, D, McHarg, S, Bayatti, N, Acar, IE, Hoyng, CCB, Fauser, S, Moore, A, Yates, JRW, Morgan, P, de Jong, EK, den Hollander, AI, Bishop, PN, Clark, SJ   +15 more
openaire   +2 more sources

DataSheet_1_Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.pdf

, 2022
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp (9129209), Ádám I. Csincsi (9129221), Mihály Józsi (345845), David Ermert (154423), Anna M. Blom (53233), Barbara Uzonyi (360778), Zsóka Szabó (6395498), Zoltán Prohászka (69659), Zsófia Bánlaki (12271835), Anna Erdei (649130), Viviana P. Ferreira (9149363), Marcell Cserhalmi (9129218), Krisztián Papp (137290)   +12 more
core   +1 more source

The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H. [PDF]

Invest Ophthalmol Vis Sci
Purpose: Little is known about sialic acids of the human retina, despite their integral role in self /non-self-discrimination by complement factor H (FH), the alternative complement pathway inhibitor.
Swan J, Toomey CB, Bergstrand M, Cuello HA, Robie J, Yu H, Yuan Y, Kooner AS, Chen X, Shaughnessy J, Ram S, Varki A, Gagneux P.   +12 more
europepmc   +2 more sources