Results 181 to 190 of about 16,055,310 (231)

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

Arthritis &Rheumatology, Accepted Article.
Objective Real‐world initial treatment strategies in SSc‐PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. Methods We analysed treatment‐naïve SSc‐PAH patients in EUSTAR (2000–2021) fulfilling the 2022 haemodynamic definition.
Hilde Jenssen Bjørkekjær, Cosimo Bruni, Kaspar Broch, Cathrine Brunborg, Patricia E Carreira, Paolo Airò, Carmen Pilar Simeón‐Aznar, Marie‐Elise Truchetet, Alessandro Giollo, Alexandra Balbir‐Gurman, Mickael Martin, Christopher P Denton, Armando Gabrielli, Francesco Del Galdo, Madelon C. Vonk, Håvard Fretheim, Helle Bitter, Øyvind Midtvedt, Arne K. Andreassen, Sverre Høie, Yoshiya Tanaka, Gabriela Riemekasten, Ulf Müller‐Ladner, Marco Matucci‐Cerinic, Ivan Castellví, Elise Siegert, Eric Hachulla, Øyvind Molberg, Oliver Distler, Anna‐Maria Hoffmann‐Vold, on behalf of the EUSTAR collaborators   +30 more
wiley   +1 more source

High-resolution spatial transcriptomics of irradiated submandibular glands treated with fortified fibrin hydrogels. [PDF]

iScience
Nam K, Maienschein-Cline M, Tavares Dos Santos H, Maslow FM, Osorio RA, Andreadis ST, Baker OJ.   +6 more
europepmc   +1 more source

Combined Anterior Cruciate Ligament Reconstruction and Anterolateral Ligament Reconstruction With Hamstring Autograft Augmented With a Reinforced Bioinductive Scaffold

Arthroscopy Techniques, EarlyView.
Abstract Combined anterior cruciate ligament and anterolateral ligament reconstruction is indicated for patients with anterior cruciate ligament rupture and preoperative rotatory instability. In smaller patients, the smaller graft diameter and shorter lengths of the gracilis and semitendinosus graft may not be sufficient for performing a combined ...
Cheuk‐Wai Wong, Christine Yuen‐Shan Lai, Keith Hay‐Man Wan, Richard Hin‐Lun Lee, Eugene Pak‐Lin Ng   +4 more
wiley   +1 more source

Lipid-Laden M1-like Macrophages of Familial Hypercholesterolemia Patients Are Characterized by Increased Interleukin-1β Secretion and Reduced <i>TMEM176A</i> and <i>TMEM176B</i> Gene Expression. [PDF]

Curr Issues Mol Biol
Izyumchenko A, Usenko T, Dracheva K, Legostaeva K, Urazgildeeva S, Tanayants K, Grunina M, Larionova E, Suchko P, Glotov O, Kulikov A, Pchelina S, Miroshnikova V.   +12 more
europepmc   +1 more source

The Boston All‐in‐One Medial Patellofemoral Complex Reconstruction: A Combined Medial Patellofemoral Ligament and Medial Quadriceps Tendon Femoral Ligament Dynamic Tensioning Technique Using Allograft

Arthroscopy Techniques, EarlyView.
Abstract Recent anatomical understanding of the medial restraints of the patella has evolved over the last decade with a current focus on the medial quadriceps tendon femoral ligament, a distinct anatomical structure to the medial patellofemoral ligament. These combine to form the medial patellofemoral complex. This technical note describes a technique
Khalid Al‐Hourani, Xinning Li
wiley   +1 more source

One‐Step Electrodeposition of Iron Oxyhydroxide Onto 3D Porous Graphene Substrates for on Chip Asymmetric Micro‐Supercapacitors

Batteries &Supercaps, Volume 8, Issue 3, March 2025.
A micro‐supercapacitor with electrodeposited iron oxyhydroxide (FeOOH) as the negative electrode and birnessite manganese oxide (MnO2) as the positive electrode achieves a 2 V working voltage, stable cycling in an aqueous electrolyte, and high energy and power densities of 21 μWh cm‐2 and 2.5 mW cm‐2 respectively.
Filipe Braga, Gabriel Casano, Manel Sonni, Harry Finch, Vinod R. Dhanak, Marco Caffio, Laurence J. Hardwick   +6 more
wiley   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Many hosts, many solutions: How reservoirs shape Borrelia protein diversity. [PDF]

PLoS Pathog
Ciglbauerová S, Strnad M, Rego ROM.
europepmc   +1 more source

The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans

British Journal of Clinical Pharmacology, EarlyView.
Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange   +3 more
wiley   +1 more source

Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis. [PDF]

J Clin Invest
Sun S, Yan XY, Dong YH, You JM, Guo ZY, Lv DX, Xie SS, Hou R, Li XY, Yu JT, Shen XY, Wei J, Song ZY, Chen ZQ, Zhu YL, Xu XX, Jin J, Wen JG, Wang H, Meng XM, Wang W.   +20 more
europepmc   +1 more source