Biological networks and epistasis in genome-wide association studies [PDF]
, 2007 Over the last few years, technological improvements have made possible the genotyping of hundreds of thousands of SNPs, enabling whole-genome association studies.
Leif Schauser +3 more
core +3 more sources
Metagenomic study of the human skin microbiome associated with acne [PDF]
, 2010 The human microbiota contributes to our normal postnatal development and plays a significant role in defining our physiology. To understand the role of microbiota in human health and disease, we study the skin microbiome in pilosebaceous units (hair ...
Huiying Li
core +2 more sources
Study Of Phenothiazine On p53 Core Domain Mutant Y220C: Finding The Anti-tumor Activity Of Phenothiazine [PDF]
, 2011 The tumor suppressor protein p53 is a transcription factor that plays a key role in the prevention of cancer development. The p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can accommodate stabilizing small ...
Asif Husain Naqvi +4 more
core +2 more sources
Application of Molecular Modeling to Development of New Factor Xa Inhibitors [PDF]
, 2015 In consequence of the key role of factor Xa in the clotting cascade and absence of its activity in the processes that do not affect coagulation, this protein is an attractive target for development of new blood coagulation inhibitors.
Alexey V. Sulimov +10 more
core +3 more sources
Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors [PDF]
Nature Communications, 2017 AbstractThe absence of an adequate reversal strategy to prevent and stop potential life-threatening bleeding complications is a major drawback to the clinical use of the direct oral inhibitors of blood coagulation factor Xa. Here we show that specific modifications of the substrate-binding aromatic S4 subpocket within the factor Xa active site disrupt ...
Daniël Verhoef +6 more
openaire +6 more sources
Reduced anticoagulation strategy is associated with a lower incidence of intracerebral hemorrhage in COVID-19 patients on extracorporeal membrane oxygenation [PDF]
, 2023 Background Optimal anticoagulation strategies for COVID-19 patients with the acute respiratory distress syndrome (ARDS) on venovenous extracorporeal membrane oxygenation (VV ECMO) remain uncertain.
Baedorf Kassis, Elias +15 more
core +1 more source
The discovery of rivaroxaban: translating preclinical assessments into clinical practice [PDF]
, 2013 Direct oral anticoagulants that target a single coagulation factor (such as factor Xa or thrombin) have been developed in recent years in an attempt to address some of the limitations of traditional anticoagulants.
Dagmar Kubitza +2 more
core +2 more sources
The Quasar Main Sequence explained by the combination of Eddington ratio, metallicity and orientation [PDF]
, 2019 We address the effect of orientation of the accretion disk plane and the geometry of the broad-line region (BLR) as part of an effort to understand the distribution of quasars in the optical plane of the quasar main sequence.
Czerny, Bożena +2 more
core +2 more sources
Azadirachta indica induced suppression of Mycobacterium tuberculosis secreted proteins in human monocyte [PDF]
, 2008 The H37Rv strain of MTB was grown in modified Sauton’s medium till mid-log phase. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient sedimentation on Ficoll-Paque separation medium.
Ajay Kumar, Jawed Iqbal, Najmul Islam
core +2 more sources
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source