Results 41 to 50 of about 18,668,916 (320)

Safety of 4-factor prothrombin complex concentrate (4F-PCC) for emergent reversal of factor Xa inhibitors

Journal of Intensive Care, 2018
BackgroundAlthough factor Xa inhibitors have become a popular choice for chronic oral anticoagulation, effective drug reversal remains difficult due to a lack of specific antidote.
J. Tao, E. Bukanova, S. Akhtar
semanticscholar   +1 more source

Prediction of inhibition constants of (R)-3-amidinophenylalanine inhibitors toward factor Xa by 2D-QSAR model

Vietnam Journal of Science, Technology and Engineering, 2022
A coagulation cascade forms through proteolytic reactions and involves different factors. There are two coagulation pathways, including intrinsic and extrinsic mechanisms, which converge by the formation of factor Xa.
Thi Bich Van Pham, Minh Hao Hoang
doaj   +1 more source

Assessment of anti-factor Xa activity in critically ill COVID-19 patients receiving three different anticoagulation regimens

SAGE Open Medicine, 2021
Introduction: Critically ill COVID-19 patients are at increased risk of thrombosis with an enhanced risk of bleeding. We aimed to explore the role of anti-factor Xa levels in optimizing the high-intensity anticoagulation’s safety and efficacy and finding
Mohammed A Hamad, Shereen A Dasuqi, Aamer Aleem, Rasha A Omran, Rakan M AlQahtani, Fahad A Alhammad, Abdulaziz H Alzeer   +6 more
doaj   +1 more source

The Impact of Continuous Veno-Venous Hemodiafiltration on the Efficacy of Administration of Prophylactic Doses of Enoxaparin: A Prospective Observational Study

Pharmaceuticals, 2023
Background: Critically ill patients frequently require continuous renal replacement therapy (CRRT). During CRRT, particles up to 10 kDa in size, such as enoxaparin, may be removed. The aim of this study was to determine if patients receiving prophylactic
Aleksander Aszkiełowicz, Karol P. Steckiewicz, Michał Okrągły, Magdalena A. Wujtewicz, Radosław Owczuk   +4 more
doaj   +1 more source

Factor Xa inhibitors for preventing recurrent thrombosis in patients with antiphospholipid syndrome: a longitudinal cohort study

Lupus, 2019
Objective The objective of this study was to clarify the efficacy and safety of factor Xa inhibitors for antiphospholipid syndrome patients in real world utilization. Methods This is a retrospective cohort study comprised of all consecutive patients with
Takahiro Sato, Hiroyuki Nakamura, Y. Fujieda, N. Ohnishi, Nobuya Abe, M. Kono, Masaru Kato, K. Oku, T. Bohgaki, O. Amengual, S. Yasuda, Tatsuya Atsumi   +11 more
semanticscholar   +1 more source

Reduced anticoagulation strategy is associated with a lower incidence of intracerebral hemorrhage in COVID-19 patients on extracorporeal membrane oxygenation

Intensive Care Medicine Experimental, 2023
Background Optimal anticoagulation strategies for COVID-19 patients with the acute respiratory distress syndrome (ARDS) on venovenous extracorporeal membrane oxygenation (VV ECMO) remain uncertain.
Daniel A. Hofmaenner, David Furfaro, Lennart C. Wild, Pedro David Wendel-Garcia, Elias Baedorf Kassis, Ameeka Pannu, Tobias Welte, Rolf Erlebach, Klaus Stahl, Edward Wilson Grandin, Christian Putensen, Reto A. Schuepbach, Shahzad Shaefi, Sascha David, Benjamin Seeliger, Christian Bode, for the BonHanZA study group   +16 more
doaj   +1 more source

Efficacy and Toxicity of Factor Xa Inhibitors

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Venous thromboembolism (VTE) is a serious disease that is often neglected, and effective and safe antithrombotic treatments are a public health priority.
Maryna Bondarenko, Christophe Curti, Marc Montana, Pascal Rathelot, Patrice Vanelle   +4 more
doaj   +1 more source

Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants

Platelets, 2021
Factor Xa (FXa) and thrombin exert non-hemostatic cellular actions primarily mediated through protease-activated receptors (PARs). We investigated the effect of FXa and thrombin on human late-outgrowth endothelial cells (OECs), a type of endothelial ...
Styliani Papadaki, Sofia Sidiropoulou, Iraklis C. Moschonas, Alexandros D. Tselepis   +3 more
doaj   +1 more source

Factor Va-factor Xa interaction:Effects of phospholipid vesicles of varying composition [PDF]

, 1982
The interaction between factor Xa and factor Va was investigated both in solution and in the presence of phospholipid vesicles with varying contents of phosphatidylserine.
Hemker, H. Coenraad, van de Waart, Piet, Lindhout, Theo, Rosing, Jan, Govers-Riemslag, Jose W.P.   +4 more
core   +2 more sources

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

Frontiers in Pharmacology, 2017
The kynurenine pathway of tryptophan metabolism is activated by pro-inflammatory cytokines. L-kynurenine, an upstream metabolite of the pathway, acts as a putative endothelium-derived relaxing factor, and has been hypothesized to play a causative role in
Carmine Vecchione, Carmine Vecchione, Francesco Fazio, Albino Carrizzo, Luana Lionetto, Antonio Damato, Luca Capocci, Mariateresa Ambrosio, Giuseppe Battaglia, Valeria Bruno, Valeria Bruno, Michele Madonna, Maurizio Simmaco, Ferdinando Nicoletti, Ferdinando Nicoletti   +14 more
doaj   +1 more source