Results 61 to 70 of about 40,684 (247)
A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation
Clinical Pharmacology &Therapeutics, EarlyView.The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix +4 more
wiley +1 more source
Inhibition of factor Xa and trypsin by tetrapeptide inhibitors.
, 2013 Inhibition of factor Xa and trypsin by tetrapeptide inhibitors.
Sheuli Zakia (328736) +5 more
core +1 more source
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT Companies increasingly claim to adopt artificial intelligence (AI) not only for economic but also for ecological and social purposes. However, in light of rising greenwashing, bluewashing, and ethics washing, the impact of the communicated rationale on employees' initial attitude toward AI introduction remains unclear.
Marco Baumgartner +3 more
wiley +1 more source
Efficacy and Toxicity of Factor Xa Inhibitors
Journal of Pharmacy & Pharmaceutical Sciences, 2013 Venous thromboembolism (VTE) is a serious disease that is often neglected, and effective and safe antithrombotic treatments are a public health priority. New antithrombotics such as rivaroxaban, apixaban, betrixaban, edoxaban, darexaban, TAK-442, LY517717, eribaxaban, otamixaban are being developed to overcome current therapeutic limitations.
Bondarenko, Maryna +4 more
openaire +5 more sources
Deep Underground Science and Engineering, EarlyView.The spiral conical perforations generated during methane in situ explosion fracturing operations lead to tensile fracture propagation in shale reservoirs being governed by the combined effects of impact pressure, bedding, and aperture under explosive loading. Using multiple regression analysis and digital image correlation technology, the mechanisms of
Yabo Chai +7 more
wiley +1 more source
, 2003 Previous work has shown that two molecules of a soluble form of phosphatidylserine, C6PS, bind to human and bovine factor Xa. Activity measurements along with the fluorescence of active-site-labeled human factor Xa showed that two linked sites ...
Wang, Jianfang +2 more
core +1 more source
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.A photothermal–magnetocaloric coupled aerogel evaporator is developed for actively adjustable water evaporation in complex environments. Magnetocaloric heating provides active energy compensation under low‐light conditions and disrupts interfacial hydrogen‐bond networks to promote evaporation.
Jingbo He +8 more
wiley +1 more source
Thrombin and factor Xa cleave madanin-1 and madanin-2.
, 2013 Thrombin and factor Xa cleave madanin-1 and madanin-2.
Pedro José Barbosa Pereira (60152) +2 more
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling.
, 1998 The signaling pathway initiated by factor Xa on vascular endothelial cells was investigated. Factor Xa stimulated a 5- to 10-fold increased release of nitric oxide (NO) in a dose-dependent reaction (0.1-2.5 μg/ml) unaffected by the thrombin inhibitor ...
CICALA, CARLA +9 more
core +1 more source