Results 61 to 70 of about 4,372,209 (230)

Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling.

, 1998
The signaling pathway initiated by factor Xa on vascular endothelial cells was investigated. Factor Xa stimulated a 5- to 10-fold increased release of nitric oxide (NO) in a dose-dependent reaction (0.1-2.5 μg/ml) unaffected by the thrombin inhibitor ...
CICALA, CARLA, JOHNSON K, BUCCI, MARIAROSARIA, PAPAPETROPOULOS A, SORRENTINO R, SESSA W, ALTIERI D., CIRINO, GIUSEPPE, ZACHARIOU V, PICCARDONI P, Giuseppe Cirino, Raffaella Sorrentino, Andreas Papapetropoulos, Carla Cicala, Kirk Johnson, Paola Piccardoni, Mariarosaria Bucci, Dario C. Altieri, Venetia Zachariou, William C. Sessa   +19 more
core   +1 more source

Factor Xa cleavage of tissue factor pathway inhibitor is associated with loss of anticoagulant activity [PDF]

, 1998
Tissue factor : factor VIIa induced activation of blood coagulation is inhibited by the complex between factor Xa and tissue factor pathway inhibitor (factor Xa : TFPI).
Hemker, H. Coenraad, Li, Anguo, Willems, George M., Theo Lindhout, Wun, Tze-Chein, Irene Salemink, Salemink, Irene, Anguo Li, Tze-Chein Wun, George Willems, Franssen, Jo, Coenraad Hemker, Lindhout, Theo, Jo Franssen   +13 more
core   +1 more source

Modulation of Local Environment for Selective Bicarbonate Conversion to Multi‐Carbon Products

Advanced Energy Materials, EarlyView.
Highly porous Cu electrode partially coated with an ionomer/carbon composite enables efficient conversion of bicarbonate to multi‐carbon products. By regulating the local reaction microenvironment, this strategy overcomes selectivity and reaction‐rate limitations, achieving Faradaic efficiencies of 43% for ethylene and 60% for total multi‐carbon ...
Tai Nguyen, Anh N. Nguyen, Guorui Gao, Jackson Crane, Thành Trần‐Phú, Gelson Tavares da Silva, Aldo Gonzalez‐Lopez, Hung Lai, Khac Huy Dinh, Duc‐Minh Phan‐Pham, Martin Guay, Carlos Escobedo, Rosalie K. Hocking, Jonathan Raisin, Lucia H. Mascaro, Cao‐Thang Dinh   +15 more
wiley   +1 more source

Mapping of the factor Xa-binding site on factor Va by site-directed mutagenesis.

, 2008
Activated coagulation factor V functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin. Based on introduction of extra carbohydrate side chains in recombinant factor V, we recently proposed several regions in factor Va to be ...
Dahlbäck, Björn, Villoutreix, Bruno O, Tholander, Ann-Louise, Steen, Mårten, Autin, Ludovic, Tran, Sinh, Tholander, Ann-Louise,, Tran, Sinh,, Dahlbäck, Björn,, Steen, Mårten,, Lund University.   +10 more
core   +1 more source

Comparison of DeePMD, MTP, GAP, ACE and MACE Machine‐Learned Potentials for Radiation‐Damage Simulations: A User Perspective

Advanced Intelligent Discovery, EarlyView.
The authors evaluated six machine‐learned interatomic potentials for simulating threshold displacement energies and tritium diffusion in LiAlO2 essential for tritium production. Trained on the same density functional theory data and benchmarked against traditional models for accuracy, stability, displacement energies, and cost, Moment Tensor Potential ...
Ankit Roy, Ram Devanathan, Sarah Allec, Giridhar Nandipati, Andrew M. Casella, David J. Senor, Duane D. Johnson, Ganesh Balasubramanian, Ayoub Soulami   +8 more
wiley   +1 more source

Factor Xa Inhibitory Profile of Apixaban, Betrixaban, Edoxaban, and Rivaroxaban Does Not Fully Reflect Their Biologic Spectrum

Clinical and Applied Thrombosis/Hemostasis, 2019
The currently available oral anti-Xa agents are claimed to produce their anticoagulant and antithrombotic effects solely by the inhibition of factor Xa.
Fakiha Siddiqui BDS, Debra Hoppensteadt PhD, Walter Jeske PhD, Omer Iqbal MD, Alfonso Tafur MD, Jawed Fareed PhD   +5 more
doaj   +1 more source

Association of anticoagulant therapy dosing with laboratory biomarkers and clinical outcomes in critically ill COVID-19 patients in the ICU [PDF]

Vojnosanitetski Pregled
Background/Aim. In immunothrombotic disorders such as coronavirus disease 2019 (COVID-19), D-dimer levels are frequently elevated, reflecting increased fibrin formation and turnover. Additional biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR)
Vasković Igor, Marković Marija, Arsenović Ljiljana, Ignjatović Aleksandra, Stojić Mihailo, Nešković Vojislava   +5 more
doaj   +1 more source

Osteosarcoma cell-calcium signaling through tissue factor-factor VIIa complex and factor Xa

, 2007
The cells responsible for bone formation express protease- activated receptors. Although serine protease thrombin has been shown to elicit functional responses in bone cells that impact on cell survival and alkaline phosphatase activity, nothing is known
Pochet, Roland, Nicaise, Charles, De Decker, Robert, Daubie, Valéry   +3 more
core   +1 more source

Reversing factor Xa inhibitors – clinical utility of andexanet alfa

, 2017
Scott Kaatz,1 Hardik Bhansali,1 Joseph Gibbs,2 Robert Lavender,3 Charles E Mahan,4 David G Paje5 1Division of Hospital Medicine, 2Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, 3Division of General Internal Medicine, University of ...
Gibbs J, Kaatz S, Bhansali H, Lavender R, Mahan CE, Paje DG   +5 more
core  

Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo.

, 1997
Coagulation proteases were tested in a rat model of acute inflammation. Subplantar injection of Factor Xa (10-30 microg) produced a time- and dose-dependent edema in the rat paw, and potentiated carrageenin-induced edema.
G. Ambrosini, CIRINO, GIUSEPPE, G. DeDominicis, CICALA, CARLA, M Bucci, G Ambrosini, D. C. Altieri, D C Altieri, C Cicala, L Sorrentino, G DeDominicis, BUCCI, MARIAROSARIA, L. Sorrentino, G Cirino   +13 more
core   +1 more source