Results 81 to 90 of about 40,684 (247)

Alternative Price Dynamics and Valuation of Flexible Strategies

International Journal of Finance &Economics, EarlyView.
ABSTRACT In this article, we study the optimal operational strategy of production projects. We investigate different underlying price models and determine the optimal barriers of transition to suspension, recovery, or irreversible abandonment of productive activity.
Cristina Bertolosi, Gianluca Fusai, Ioannis Kyriakou   +2 more
wiley   +1 more source

Andexanet alfa for the reversal of Factor Xa inhibitor related anticoagulation

, 2016
Andexanet alfa is a specific reversal agent for Factor Xa inhibitors. The molecule is a recombinant protein analog of factor Xa that binds to Factor Xa inhibitors and antithrombin:LMWH complex but does not trigger prothrombotic activity.
Dombrowski, KE, Levy, JH, Welsby, IJ, Ghadimi, K   +3 more
core   +1 more source

Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

, 1995
Crystal structures of DX9065a and a related bisamidino-aryl inhibitor specific for the blood-clotting factor Xa have been solved in complex with bovine β-trypsin to a resolution of 1.9 Å.
Huber, Robert, Bode, Wolfram, Robert Huber, Stubbs, Milton T., Milton T. Stubbs, Wolfram Bode   +5 more
core   +1 more source

Estimated impact of model‐guided venous thromboembolism prophylaxis versus real‐world practice

Journal of Hospital Medicine, EarlyView.
Abstract Background The American Society of Hematology (ASH) recommends assessing venous thromboembolism (VTE) and major bleeding risk to optimize pharmacological VTE prophylaxis for medical inpatients. However, the clinical utility of model‐guided approaches remains unknown.
Benjamin G Mittman, Michael B. Rothberg
wiley   +1 more source

Depth and season‐related variability in fatty acid composition and lipid nutritional quality indices of farmed Mytilus galloprovincialis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Lipid quality is one of the most important indicators of the nutritional value of farmed mussels. In open‐coastal environments, factors such as cultivation depth and seasonal changes affect lipid dynamics, but their combined effects on lipid quality remain unclear.
Meryem Yeşim Çelik, Bayram Köstekli, Gülşen Uzun Gören, Zeynep Hasançavuşoğlu, Mümin Metehan Kılıç, Alihan Bülbül, Beyza Dündar   +6 more
wiley   +1 more source

Thrombin activity generated by factor Xa and trMASP2 measured by cleavage of VPR-AMC.

, 2013
Samples (100 µl) contained 10 µg prothrombin (PT)+25 ng factor Xa (fXa), 25 ng factor Xa alone, 10 µg prothrombin+100 ng trMASP2, 100 ng trMASP2 alone or 10 µg prothrombin alone.
Anders Krarup (242938), Robert B. Sim (378841), Julia S. Presanis (378840), Péter Gál (325641), Russell Wallis (153603)   +4 more
core   +1 more source

Tranexamic Acid in Lower Extremity Endoprosthetic Reconstruction for Oncologic Indications: A Retrospective Comparative Study of 617 Patients

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives While tranexamic acid (TXA) reduces blood loss in orthopedic surgery, thromboembolic concerns in cancer patients have limited adoption in orthopedic oncology. This study evaluated TXA efficacy and safety in patients undergoing endoprosthetic reconstruction for oncologic indications.
Stephen W. Chenard, Akhil Rekulapelli, Riley S. Gilbertson, Connor S. Charton, William F. Hefley, Michael J. Colello, Jennifer L. Halpern, Herbert S. Schwartz, Daniel J. Johnson, Jonathan G. Schoenecker, Joshua M. Lawrenz   +10 more
wiley   +1 more source

Role of oral factor Xa inhibitors after acute coronary syndrome

, 2014
Despite an early invasive strategy and the use of dual antiplatelet therapy, patients with acute coronary syndrome (ACS) continue to be at substantial risk for recurrent ischemic events.
Krishnamoorthy, Parasuram, Lichstein, Edgar, Borer, Jeffrey S., Borer, Jeffrey S, Ahmad, Hasan, Lavie, Carl J., Sharma, Abhishek, Lavie, Carl J, Mukherjee, Debabrata, Garg, Jalaj, Arbab-Zadeh, Armin, Garg, Akash   +11 more
core   +1 more source

Diverging Cervical Cancer Burden in Africa in the Context of WHO's Elimination Strategy: Insights From GBD 2023

Med Research, EarlyView.
The study highlights the rising cervical cancer burden in Africa, where rates have increased since 1990. Key challenges include structural health inequalities, low HPV vaccination coverage, and limited screening. Projections suggest a continued increase in incidence, deaths, and DALYs by 2038, diverging further from global trends.
Yedong Huang, Shun Chen, Shiqi Ren, Jingwei Zhao, Ziheng Wang, Zhichao Lu, Weiye Qian, Jian Wang, Ting Zhou, Yifan Wang, Zhixin Jiao, Chenyizhe Yuan, Yucheng Hou, Dong Liu, Zhining Liu, Aimin Xu, Li Liu, Qiaojun Hong, Lin Zhang   +18 more
wiley   +1 more source

Osteosarcoma cell-calcium signaling through tissue factor–factor VIIa complex and factor Xa

, 2007
The cells responsible for bone formation express protease- activated receptors. Although serine protease thrombin has been shown to elicit functional responses in bone cells that impact on cell survival and alkaline phosphatase activity, nothing is known
Pochet, Roland, Nicaise, Charles, De Decker, Robert, Daubie, Valéry   +3 more
core   +1 more source