Results 91 to 100 of about 2,946,706 (313)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Mentoring Matters: Faculty's Role in Developing Competent Doctors

GAIMS Journal of Medical Sciences
The integration of structured mentoring programs within the medical curriculum and the inclusion of mentoring sessions in faculty development programs represent a forward-thinking approach by the NMC.
Mandar Chandrachood
doaj   +1 more source

Design, validation and dissemination of an undergraduate assessment tool using SimMan® in simulated medical emergencies [PDF]

, 2010
Background: Increasingly, medical students are being taught acute medicine using whole-body simulator manikins. Aim: We aimed to design, validate and make widely available two simple assessment tools to be used with Laerdal SimMan (R) for final year ...
Allen, Maggie E., Fraser, Ian, Kirkcaldy, Jo, Macdougall, Colin F., Paskins, Zoe, Peile, Ed   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Building a comprehensive mentoring academy for schools of health. [PDF]

, 2019
Formal mentoring programs are increasingly recognized as critical for faculty career development. We describe a mentoring academy (MA) developed for faculty across tracks (i.e., researchers, clinicians, educators) within a "school of health" encompassing
Giacinto, Rebeca E, Meyers, Frederick J, Rainwater, Julie A, Sauder, Candice AM, Schweitzer, Julie B, Ton, Hendry   +5 more
core  

Evolution of the medical faculty from Tıphane to Cerrahpaşa Medical Faculty (1827–2019)

Cerrahpaşa Medical Journal, 2020
Cerrahpaşa Medical Faculty, located in the Fatih district of Istanbul, derives its name from its neighborhood and is the oldest medical faculty in our country besides Istanbul Medical Faculty. The historical origin of the faculty goes back to Tophane-i-Amire, which was established on March 14, 1827.
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Clinical mentoring programs for medical students, practical points in design, implementation and evaluation

Journal of Medical Education and Development, 2018
Introduction: Although Mentoring programs are one of the essential reasons of professional development for medical students, most academics experience lack of them.
Saeed Pourhassan
doaj  

Faculty development courses in medicine: a fruitful field [PDF]

, 2012
Therefore we endeavor a systematic literature review (1997-2007) in the area of tutors graduation in doctors curriculum oriented in learning based on problems through: research, recognition, selection and study analysis on the data bases: Scielo, Lilacs,
Batista, Sylvia Helena Souza da Silva, Rêgo, Cinthia   +1 more
core   +1 more source