Results 101 to 110 of about 2,946,706 (313)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Paradigms in the teaching of medical research: a view from the classroom, to the classroom

Revista Ciencias Biomédicas, 2010
The guidelines of the University of Cartagena for comprehensive professional training, provide for the inclusion of the research component. In the medical program, research is the cornerstone for the construction of new knowledge, that today, directs the
Ramos Clason Enrique Carlos, Márquez-Cárdenas Evelio José   +1 more
doaj  

A formação do professor de Medicina como "intelectual": uma análise crítica

Revista Brasileira de Educação Médica
As diretrizes curriculares nacionais de 2001 demandam uma consistente formação em humanidades por parte do egresso da graduação em Medicina. A fim de cumprir essa exigência, caberia ao docente uma nova tarefa frente ao alunato, além da produção de ...
Marcos Antonio Almeida Santos
doaj   +1 more source

Clinician to Medical Teacher: Perspectives for the First Year

MedEdPublish, 2021
Practicing physicians may follow the desire to enter full-time academic medicine as a clinician-educator. There is a paucity of literature to inform the clinician with a successful framework in transitioning to all the necessary roles encountered as a ...
Robert Tyler, Mariam Akhtar, Michael Selby, Ken Stewart, Robert Arnce   +4 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Efetividade da Avaliação Programática do Estudante de Medicina: Estudo de Caso Baseado nas Impressões de Estudantes e Professores de uma Escola Médica Britânica

Revista Brasileira de Educação Médica
RESUMO A avaliação programática do estudante é uma abordagem relativamente nova, que tem como objetivo principal o aperfeiçoamento das condições de utilização dos diferentes métodos de avaliação, com vistas ao melhor cumprimento das funções da avaliação:
Luiz Ernesto de Almeida Troncon
doaj   +1 more source

Interview with Millicent Goldschmidt [PDF]

, 2017
An oral history interview with Millicent Goldschmidt about her career at University of Texas Health Science Center at Houston (UTHealth) where she has held faculty positions in the Department of Diagnostic and Biomedical Sciences at UTHealth School of ...
Goldscmidt, Millicent, Ph.D.
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source