Results 31 to 40 of about 5,098 (167)

Protein Prenylation Makeovers in Plants: Insights into Substrate Diversification. [PDF]

Int J Mol Sci
Type-I protein prenylation, the post-translational modification of CaaX motif-containing proteins, relies on two substrates: the target protein and a mevalonate-derived prenyl diphosphate co-substrate, either farnesyl diphosphate (FPP) or geranylgeranyl ...
Chevalier Q, Debié P, Huchelmann A, Hemmerlin A.   +3 more
europepmc   +2 more sources

Weekly paclitaxel, gemcitabine, and external irradiation followed by randomized farnesyl transferase inhibitor R115777 for locally advanced pancreatic cancer. [PDF]

, 2012
PURPOSE: The Radiation Therapy Oncology Group (RTOG) multi-institutional Phase II study 98-12, evaluating paclitaxel and concurrent radiation (RT) for locally advanced pancreatic cancer, demonstrated a median survival of 11.3 months and a 1-year survival
Anne, Pramila R, Cline-Burkhardt, Vivian Jm, Erickson, Beth, Hoffman, John P, Myerson, Robert J, Perez, Kimberly, Rich, Tyvin A, Safran, Howard, Willett, Christopher, Winter, Kathryn   +9 more
core   +1 more source

Alteration of Mevalonate Pathway Related Enzyme Expressions in Pressure Overload-Induced Cardiac Hypertrophy and Associated Heart Failure with Preserved Ejection Fraction

Cellular Physiology and Biochemistry, 2013
Background: Abnormalities of the mevalonate pathway, an important cellular metabolic pathway, are common in many diseases including cardiovascular disease. The mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy
Bin Chen, Li-Yun Zhong, Jin-Xiu Yang, Yan-Yun Pan, Fei Chen, Jian Yang, Tao Wu, Shen-Jiang Hu   +7 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum [PDF]

, 2011
The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human ...
JORDÃO, Fabiana Morandi, KATZIN, Alejandro Miguel, KIMURA, Emília Akemi   +2 more
core   +3 more sources

Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats

Frontiers in Molecular Neuroscience, 2018
Alcohol use disorder (AUD) is associated with persistent adaptations in the brain that are believed to participate in the long-lasting vulnerability to relapse after abstinence.
Josette Alsebaaly, Josette Alsebaaly, Emilie Dugast, Emilie Dugast, Laure Favot, Lydia Rabbaa Khabbaz, Marcello Solinas, Nathalie Thiriet   +7 more
doaj   +1 more source

Cloning and characterisation of chlorophyll synthase from Avena sativa [PDF]

, 2001
The chlorophyll synthase gene from oat (Avena sativa) was cloned and expressed in Escherichia coli. The deduced amino acid sequence consists of 378 amino acids including a presequence, of 46 amino acids.
Kögel, Julia, Lenz, Stefan, Oster, Ulrike, Rüdiger, Wolfhart, Schmid, Heidi C.   +4 more
core   +1 more source

Pharmacogenetics of osteoporosis: a pathway analysis of the genetic influence on the effects of antiresorptive drugs [PDF]

, 2022
Osteoporosis is a skeletal disorder defined by a decreased bone mineral density (BMD) and an increased susceptibility to fractures. Bisphosphonates and selective oestrogen receptor modulators (SERM) are among the most widely used drugs. They inhibit bone
Hernández Hernández, José Luis, Olmos Martínez, José Manuel, Real Bolt, Álvaro del, Riancho Moral, José Antonio, Valero Díaz de Lamadrid, Carmen   +4 more
core   +1 more source

Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin [PDF]

, 2017
Animal health depends on the ability of immune cells to kill invading pathogens, and on the resilience of tissues to tolerate the presence of pathogens.
A Baxter, A Bellier, A Das, AE Christian, AF Read, B Page, BH Jost, BN Bonnett, CY Kao, DL Huffman, DO Ballard, DS Schneider, EP Kilsdonk, G Krikun, G Preta, GD Healey, IM Sheldon, IM Sheldon, JD Bergstrom, JG Cronin, JL Goldstein, JL Goldstein, JM Park, JW Rosch, K Bloch, KS Giddings, L Gurcel, L Pokrajac, L Raberg, LJ Bischof, LJ Sharpe, MD Peraro, MJ Rogers, ML Turner, MLS Bicalho, MR Amos, MR Gonzalez, R Medzhitov, RK Tweten, S Statt, S Westermann, SA Bustin, SJ Billington, SJ Billington, SJ Billington, T Mosmann, Y Lange   +46 more
core   +2 more sources

Additional file 4 of Glucose starvation suppresses gastric cancer through targeting miR-216a-5p/Farnesyl-Diphosphate Farnesyltransferase 1 axis

, 2021
Additional file 4: Table S1. The sequences of oligo dT and primers used in this study.
Zhao, Ruiyang, Cao, Bo, Li, Hanghang, Li, Tian, Xu, Xingming, Cui, Hao, Deng, Huan, Wei, Bo   +7 more
openaire   +1 more source