Results 11 to 20 of about 9,308 (197)

Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. [PDF]

PLoS ONE, 2015
OBJECTIVE:Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients.
Harumasa Nakazawa, Marina Yamada, Tomokazu Tanaka, Joshua Kramer, Yong-Ming Yu, Alan J Fischman, J A Jeevendra Martyn, Ronald G Tompkins, Masao Kaneki   +8 more
doaj   +9 more sources

Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase gene (MVK). MKD has heterogeneous clinical phenotypes: the correlation between MVK mutations and MKD clinical phenotype is still to be ...
Paola Maura Tricarico, Alessandra Romeo, Rossella Gratton, Sergio Crovella, Fulvio Celsi   +4 more
doaj   +3 more sources

Decreased PTGES2 Farnesylation in Granulosa Cells Compromises PGE2-Dependent Cumulus Expansion and Oocyte Maturation During Ovarian Aging. [PDF]

Aging Cell
A schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Zhang S, Qi J, Liu C, Zhang H, Guo B, Wu D, Liu Y, Zhen X, Zhang Y, Kang N, Zhou J, Yan G, Li C, Ding L, Sun H.   +14 more
europepmc   +2 more sources

Development of a Genetically Encoded and Potent PDE6D Inhibitor. [PDF]

Chembiochem
PDE6D is a trafficking chaperone of prenylated proteins. Current small molecule PDE6D inhibitors target its hydrophobic pocket, rendering them typically poorly water soluble. Herein, PDE6D binders are generated by combining parts of the K‐Ras4B and INPP5E C‐termini. The genetically encoded high‐affinity PDE6D inhibitor SNAP‐STI is thus generated.
Gómez-Mulas A, Schaffner-Reckinger E, Peeters H, Chippalkatti R, Dautbasic A, Smith MJ, Ismail S, Abankwa DK.   +7 more
europepmc   +2 more sources

Evaluating protein prenylation of human and viral CaaX sequences using a humanized yeast system

Disease Models & Mechanisms
Emily R. Hildebrandt, Anushka Sarkar, Rajani Ravishankar, June H. Kim, Walter K. Schmidt   +4 more
doaj   +2 more sources

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. [PDF]

, 2016
Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets.
Carpenter, Elisabeth P, Gault, Joseph, Marcoux, Julien, Mehmood, Shahid, Michaelis, Susan, Quigley, Andrew, Robinson, Carol V, Young, Stephen G   +7 more
core   +2 more sources

Genomic instability and DNA replication defects in progeroid syndromes [PDF]

, 2018
Progeroid syndromes induced by mutations in lamin A or in its interactors – named progeroid laminopathies – are model systems for the dissection of the molecular pathways causing physio- logical and premature aging.
Chiara Merigliano, Fiammetta Vernì, Isabella Saggio, Mattia La Torre, Romina Burla   +4 more
core   +1 more source

Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity.

PLoS Computational Biology, 2011
Farnesylation is an important post-translational modification catalyzed by farnesyltransferase (FTase). Until recently it was believed that a C-terminal CaaX motif is required for farnesylation, but recent experiments have revealed larger substrate ...
Nir London, Corissa L Lamphear, James L Hougland, Carol A Fierke, Ora Schueler-Furman   +4 more
doaj   +1 more source

Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARγ Expression and Activation in Differentiating Mesenchymal Stem Cells

PPAR Research, 2007
Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white adipose tissue protein, farnesylation has shown to be essential for the successful differentiation of preadipocytes into ...
Daniel Rivas, Rahima Akter, Gustavo Duque   +2 more
doaj   +1 more source

Investigation of LKB1 Ser⁴³¹ phosphorylation and Cys⁴³³ farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity [PDF]

, 2014
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser(431)
Alessi, Alessi, Alessi, Andrade-Vieira, Baas, Barnes, Bayascas, Boudeau, Boudeau, Boutin, Carling, Carling, Chen, Clark, Collins, Corton, Dario R. Alessi, Davisson, Denison, Denison, Farnsworth, Fogarty, Fogarty, Foretz, Gwinn, Hardie, Hardie, Hawley, Hayashi, Hemminki, Henriksson, Hunter, Jansen, Jeppesen, Ji, Joby Varghese, Kei Sakamoto, Kishi, Koh, Komander, Liu, Lizcano, Maria Stella Ritorto, Martin, McLaughlin, Mitchelhill, Moores, Mora, Najafov, Nakada, Natalia Shpiro, Oakhill, Paul Davies, Robert Gourlay, Sakamoto, Sakamoto, Sakamoto, Sanchez-Cespedes, Sanchez-Cespedes, Sanders, Sapkota, Sapkota, Screaton, Shaw, Shelly, Su, Towler, Vanessa P. Houde, Vavvas, Viollet, Wiggin, Woods, Wullschleger, Zagorska, Zeqiraj, Zeqiraj, Zhang   +76 more
core   +2 more sources