Results 21 to 30 of about 9,308 (197)

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

Journal of Lipid Research, 2010
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of a farnesylated form of prelamin A (progerin). Previously, we showed that blocking protein farnesylation with a farnesyltransferase inhibitor (FTI) ameliorates the disease ...
Shao H. Yang, Sandy Y. Chang, Douglas A. Andres, H. Peter Spielmann, Stephen G. Young, Loren G. Fong   +5 more
doaj   +1 more source

Protein Farnesylation Takes Part in Arabidopsis Seed Development

Frontiers in Plant Science, 2021
Protein farnesylation is a post-translational modification regulated by the ERA1 (Enhanced Response to ABA 1) gene encoding the β-subunit of the protein farnesyltransferase in Arabidopsis.
Valentin Vergès, Christelle Dutilleul, Béatrice Godin, Boris Collet, Alain Lecureuil, Loïc Rajjou, Cyrille Guimaraes, Michelle Pinault, Stéphane Chevalier, Nathalie Giglioli-Guivarc’h, Eric Ducos   +10 more
doaj   +1 more source

Farnesyltransferase inhibitors and human malignant pleural mesothelioma: a first-step comparative translational study. [PDF]

, 2005
It is known that the potential clinical use of farnesyltransferase inhibitors (FTI) could be expanded to include cancers harboring activated receptor tyrosine kinases.
Cardaci V, Catassi A, Cesario A, Dominioni L, Festi L, Galetta D, Granone P, Imperatori A, Margaritora S, Pericelli A, Porziella V, Russo P.   +11 more
core   +1 more source

Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

Acta Neuropathologica Communications, 2021
The pathogenic mechanisms underlying the development of Alzheimer’s disease (AD) remain elusive and to date there are no effective prevention or treatment for AD.
Angela Jeong, Shaowu Cheng, Rui Zhong, David A. Bennett, Martin O. Bergö, Ling Li   +5 more
doaj   +1 more source

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]

, 2015
BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir, Lewis, Michael, Lu, Jie, Mortazavi, Fariborz, Pezeshkpour, Gholamhossein, Phan, Ryan, Tamanoi, Fuyuhiko, Trinidad, Kenny   +7 more
core   +2 more sources

Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

Journal of Lipid Research, 2009
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the synthesis of a truncated prelamin A, commonly called progerin, that contains a carboxyl-terminal farnesyl lipid anchor.
Brandon S.J. Davies, Shao H. Yang, Emily Farber, Roger Lee, Suzanne B. Buck, Douglas A. Andres, H. Peter Spielmann, Brian J. Agnew, Fuyuhiko Tamanoi, Loren G. Fong, Stephen G. Young   +10 more
doaj   +1 more source

GGPS1 Promoter Variant (rs3806394) Is Associated With Larger Simple Renal Cysts via Reduced GGPPS Expression. [PDF]

Hum Mutat
Objective We are aimed at investigating the association between the size of simple renal cyst (SRC) and the expression of geranylgeranyl pyrophosphate synthase (GGPPS), which can induce renal cyst formation after its deletion. Methods Seventy‐seven patients who received renal cyst decortication were enrolled.
Wang K, Tang T, Xu T, Chen Z, Gou L, Wang Y, Wang D, Wu J, Wang X, Xue B, Xu X.   +10 more
europepmc   +2 more sources

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells [PDF]

, 2006
BACKGROUND: Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway ...
M Goffinet, M Thoulouzan, A Pradines, I Lajoie-Mazenc, Carolyn Weinbaum, JC Faye, S Séronie-Vivien, MJ Rogers, JR Green, D Amin, JD Bergstrom, K Thompson, E van Beek, HL Benford, SP Luckman, T Iguchi, JE Fisher, K Sawada, C Denoyelle, FP Coxon, ER Van Beek, GM Oades, SG Senaratne, SS Virtanen, F Saad, MR Smith, S Boissier, MV Lee, EC Lerner, TF McGuire, O Cussenot, P Skehan, AB Awad, E Corey, DC Crick, RB Lobell, SA Holstein, SE Ownby, C Allal, JE Dunford, JE Fisher   +40 more
core   +2 more sources

C-Terminal Farnesylation of UCH-L1 Plays a Role in Transport of Epstein-Barr Virus Primary Oncoprotein LMP1 to Exosomes

mSphere, 2018
Increasing evidence shows that exosomes are key regulators in cancer cell-to-cell communication. Several reports on Epstein-Barr virus (EBV)-related malignancies demonstrate that latent membrane protein 1 (LMP1) secreted by exosomes derived from EBV- or ...
E. Kobayashi, M. Aga, S. Kondo, C. Whitehurst, T. Yoshizaki, J. S. Pagano, J. Shackelford   +6 more
doaj   +1 more source

HDV can constrain HBV genetic evolution in hbsag: Implications for the identification of innovative pharmacological targets [PDF]

, 2018
Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection.
Andreoni, Massimo, Angelico, Mario, Barlattani, Angelo, Battisti, Arianna, Bertoli, Ada, Cappiello, Giuseppina, Carioti, Luca, Ceccherini-Silberstein, Francesca, Colagrossi, Luna, Coppola, Nicola, De Cristofaro, Maria, DE SANCTIS, Giuseppe Maria, Fabeni, Lavinia, Fleury, Hervé, Iapadre, Nerio, Lanza, Alfonso Galeota, Lenci, Ilaria, Lichtner, Miriam, Malagnino, Vincenzo, Mari, Terenzio, Marignani, Massimo, Mastroianni, Claudio, Minichini, Carmine, Nebuloso, Elena, Pasquazzi, Caterina, Perno, Carlo-Federico, Piermatteo, Lorenzo, Salpini, Romina, Sarmati, Loredana, Scutari, Rossana, Spanò, Alberto, Stanzione, Maria, Stornaiuolo, Gianfranca, Svicher, Valentina, Trimoulet, Pascale   +34 more
core   +2 more sources