Results 31 to 40 of about 9,308 (197)
Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase
Cell Reports, 2017 Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies have demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleotides.
Natasha Emmanuel +9 more
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Cells, 2022 Mutations in the genes LMNA and BANF1 can lead to accelerated aging syndromes called progeria. The protein products of these genes, A-type lamins and BAF, respectively, are nuclear envelope (NE) proteins that interact and participate in various cellular ...
Rhiannon M. Sears, Kyle J. Roux
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Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins [PDF]
, 1995 We have identified a gene, SHR5, in a screen for extragenic suppressors of the hyperactive RAS2Val-19 mutation in the budding yeast Saccharomyces cerevisiae. SHR5 was cloned, sequenced, and found to encode a 23-kDa protein not significantly homologous to
Jung, V. +4 more
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Journal of Lipid Research, 2010 Over a hundred proteins in eukaryotic cells carry a C-terminal CaaX box sequence, which targets them for posttranslational isoprenylation of the cysteine residue.
Julia M. Fres +2 more
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Frontiers in Molecular Neuroscience, 2018 Primary cilia are microtubule-based organelles, which protrude from the plasma membrane and receive a wide range of extracellular signals. Various cilia use G protein-coupled receptors (GPCRs) for the detection of these signals.
Celine Brooks +7 more
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Statins and protein prenylation in cancer cell biology and therapy [PDF]
, 2012 El pdf del artículo es la versión post-print.The use of statins has scaled up to become one of the most prescribed medicines in the world and have been very useful in the manegement of cardiovascular diseases and related mortality.
Fernández-Checa, José C. +2 more
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Age-dependent changes of nuclear morphology are uncoupled from longevity in Caenorhabditis elegans IGF/insulin receptor daf-2 mutants [PDF]
, 2016 Nuclear envelope (NE) architecture and aging have been associated since the discovery that certain human progeria diseases are due to perturbations in processing of lamin A protein, generating alterations in NE morphology. However, whether changes in the
Askjaer, Peter +4 more
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Neoplasia: An International Journal for Oncology Research, 2000 Pancreatic ductal adenocarcinoma is a highly lethal malignancy that is resistant to traditional cytotoxic therapy. High rates of activating codon 12 K-Ras mutations in this disease have generated considerable interest in the therapeutic application of ...
Si Young Song +4 more
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Preliminary studies of biosynthesis of heme O and heme A in intraerythrocytic stages of P. falciparum [PDF]
, 2014 Intermediates of the isoprenoid metabolism can bind to heme groups. Heme is critical and its derivatives, heme O and heme A, are the main compounds of aerobic respiration. They are synthesized by farnesylation of heme groups by ?heme O synthase?
Cirulli, Brenda Analía +5 more
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Journal of Lipid Research, 2006 Proteins that terminate with a consensus sequence known as CAAX undergo a series of posttranslational modifications that include polyisoprenylation, endoproteolysis, and carboxyl methylation.
Latasha P. Wright, Mark R. Philips
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