Results 41 to 50 of about 9,308 (197)

Mouse models for understanding the molecular mechanism of bone disease in Hutchinson-Gilford progeria syndrome [PDF]

, 2011
Aging is a complex process affecting all people. Intense research is applied to elucidate the biological basis of aging and disease that develop with aging.
Schmidt, Eva
core   +1 more source

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.

PLoS Biology, 2018
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation.
Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, R A John Challiss, Flaviano Giorgini, Joern R Steinert   +14 more
doaj   +1 more source

Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification. [PDF]

PLoS Genetics, 2013
The core planar polarity proteins are required to specify the orientation of structures that are polarised in the plane of the epithelium. In the Drosophila melanogaster wing, the core proteins localise asymmetrically at either proximal or distal cell ...
Helen Strutt, Vickie Thomas-MacArthur, David Strutt   +2 more
doaj   +1 more source

The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization [PDF]

, 1994
C-terminal lipid modifications are essential for the interaction of Ras-related proteins with membranes. While all Ras proteins are farnesylated and some palmitoylated, the majority of other Ras-related proteins are geranylgeranylated.
Beranger, F., Paterson, H., Powers, S., de Gunzburg, J., Hancock, J. F.   +4 more
core   +1 more source

Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides

Cells, 2018
The mammalian nuclear lamina proteins—prelamin A- and B-type lamins—are post-translationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxy-terminal CAAX (C, cysteine; a, aliphatic amino acid; X, any amino ...
Xiang Lu, Karima Djabali
doaj   +1 more source

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104) [PDF]

, 2012
BACKGROUND: Multiple farnesylated proteins are involved in signal transduction in cancer. Farnesyltransferase inhibitors (FTIs) have been developed as a strategy to inhibit the function of these proteins.
A Boni, A Hauschild, AD Basso, AL Shada, April KS Salama, AS Yazdi, C Robert, CJ Punt, Cynthia Bucher, D Dankort, Donna Niedzwiecki, DS Hong, DW End, E Atallah, FE Meier, FE Meier, Frank Haluska, FS Hodi, Gerald Linette, H Tsao, H Tsao, J Ackermann, J Czyzyk, JA Sosman, JA Sparano, JE Karp, JE Lancet, Jeffrey Johnson, JL Harousseau, JY Han, K Satyamoorthy, K Zhu, KA Margolin, KL van Golen, KS Smalley, KT Flaherty, M Alsina, M Crul, M Huncharek, MB Atkins, Michelle A Blaskovich, MR Middleton, MS Brose, N Berndt, N Dhomen, P Guldberg, PB Chapman, R Kefford, R Kurzrock, R Kurzrock, RA Mesa, RA Padua, RE Marks, SA Rosenberg, SA Rosenberg, Said M Sebti, T Hocker, Thomas F Gajewski, TM Zimmerman, V’t Veer LJ, Z Ji   +60 more
core   +2 more sources

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer [PDF]

, 2019
BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC).
Díaz Moreno, Irene, Díaz Quintana, Antonio Jesús, García Rodríguez, JL, Serrano Macía, M., Zubiete Franco, I   +4 more
core   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source