Results 51 to 60 of about 9,308 (197)

Mammalian telomeres and their partnership with lamins [PDF]

, 2016
Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA, LA TORRE, MATTIA, SAGGIO, Isabella   +2 more
core   +1 more source

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Emma Beard, Safa El‐Bushra, Zahra Kader, Yujiao Jennifer Sun, Ngan Pan Bennett Au   +4 more
wiley   +1 more source

A phase 1 trial dose-escalation study of tipifarnib on a week-on, week-off schedule in relapsed, refractory or high-risk myeloid leukemia. [PDF]

, 2011
Inhibition of farnesyltransferase (FT) activity has been associated with in vitro and in vivo anti-leukemia activity. We report the results of a phase 1 dose-escalation study of tipifarnib, an oral FT inhibitor, in patients with relapsed, refractory or ...
Forman, SJ, Frankel, P, Karanes, C, Kirschbaum, MH, Newman, EM, O'Donnell, MR, Popplewell, L, Pulone, B, Rincon, A, Stein, AS, Synold, T, Tuscano, J, Wright, J, Zain, JM   +13 more
core  

Farnesyl Diphosphate Synthase Assay

, 2014
Farnesyl diphosphate synthase (FPS) catalyzes the sequential head-to-tail condensation of isopentenyl diphosphate (IPP, C5) with dimethylallyl diphosphate (DMAPP, C5) and geranyl diphosphate (GPP, C10) to produce farnesyl diphosphate (FPP, C15). This short-chain prenyl diphosphate constitutes a key branch-point of the isoprenoid biosynthetic pathway ...
Arró, Montserrat, Manzano, David, Ferrer, Albert   +2 more
openaire   +3 more sources

Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease [PDF]

, 2017
The high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effectively prevent and/or reverse renal fibrosis. Therefore, the aim of this study was to evaluate the effect of long-term treatment with chaethomellic acid A (
Ana Isabel Faustino-Rocha, Anderson, António Nogueira, Asaba, Aura Colaço, Barnes, Bohle, Brenner, Buturovic-Ponikvar, Carlos André Pires, Carmen Vasconcelos-Nóbrega, Cheng, Coimbra, Cuda, Dong, Downward, Ebihara, Ehrhardt, Floege, Forbes, Fuentes-Calvo, Fuentes-Calvo, Fujihara, Fujihara, Gaertner, Gibbs, Gill, Grande, Grande, Hahn, Hahn, Haurani, He, Helena Vala, Hendry, Kolofousi, Krepinsky, Krepinsky, Lassegue, Liu, López-Hernández, López-Novoa, Maria João Pires, Martínez-Salgado, Martínez-Salgado, Midgley, Mills, Moubarak, Muchaneta-Kubara, Muñoz-Félix, Nogueira, Nogueira, Pagano, Paula Alexandra Oliveira, Pires, Qian, Reuther, Rodríguez-Peña, Rodríguez-Peña, Ruocco, Sabbatini, Sabbatini, Sachse, Santillo, Serù, Sharpe, Tain, Takai, Tapia, Waldherr, Wang   +70 more
core   +2 more sources

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

eLife, 2019
Delivery of native or chemically modified recombinant proteins into mammalian cells shows promise for functional investigations and various technological applications, but concerns that sub-cellular localization and functional integrity of delivered ...
Amal Alex, Valentina Piano, Soumitra Polley, Marchel Stuiver, Stephanie Voss, Giuseppe Ciossani, Katharina Overlack, Beate Voss, Sabine Wohlgemuth, Arsen Petrovic, Yaowen Wu, Philipp Selenko, Andrea Musacchio, Stefano Maffini   +13 more
doaj   +1 more source

A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake

Redox Biology, 2020
UCH-L1 is a deubiquitinating enzyme (DUB), highly abundant in neurons, with a sub-cellular localization dependent on its farnesylation state. Despite UCH-L1′s association with familial Parkinson's Disease (PD), the effects on mitochondrial bioenergetics ...
Fernanda M. Cerqueira, Sophia von Stockum, Marta Giacomello, Inna Goliand, Pamela Kakimoto, Elena Marchesan, Diego De Stefani, Alicia J. Kowaltowski, Elena Ziviani, Orian S. Shirihai   +9 more
doaj   +1 more source

Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulin. [PDF]

PLoS ONE, 2011
BACKGROUND: Ras protein, as one of intracellular signal switches, plays various roles in several cell activities such as differentiation and proliferation.
Ling-Jia Wu, Li-Rong Xu, Jun-Ming Liao, Jie Chen, Yi Liang   +4 more
doaj   +1 more source

Complex Systems Analysis of Arrested Neural Cell Differentiation during Development and Analogous Cell Cycling Models in Carcinogenesis [PDF]

, 2004
A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell cycling network transformations involved in ...
Baianu, Professor I.C., Prisecaru, M.S. V   +1 more
core  

Legionella: from protozoa to humans [PDF]

, 2011
International audiencePathogens that are able to enter and multi- ply within human cells are responsible for multiple diseases and millions of deaths worldwide.
Carmen Buchrieser
core   +1 more source