Results 81 to 90 of about 9,308 (197)

Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance [PDF]

, 2016
Background A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior.
Purdy, Ashley M., Sun, Simon D., Walsh, Gregory S.   +2 more
core   +2 more sources

Baricitinib Augments Lonafarnib Therapy to Preserve Colonic Homeostasis and Microbial Balance in a Mouse Model of Progeria

Aging Cell, Volume 24, Issue 12, December 2025.
Combined baricitinib and lonafarnib treatment improved colonic pathology in LmnaG609G/G609G progeria mice by reducing progerin, maintaining epithelial regeneration, mitigating inflammation and senescence, and preserving microbiome composition. ABSTRACT Hutchinson‐Gilford Progeria Syndrome (HGPS) is a fatal genetic disorder caused by progerin, a mutant ...
Moritz Schroll, Yacine Amar, Peter Krüger, Klaus Neuhaus, Karima Djabali   +4 more
wiley   +1 more source

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition. [PDF]

PLoS ONE, 2010
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by a de novo heterozygous point mutation G608G (GGC>GGT) within exon 11 of LMNA gene encoding A-type nuclear lamins.
Jackleen Marji, Seán I O'Donoghue, Dayle McClintock, Venkata P Satagopam, Reinhard Schneider, Desiree Ratner, Howard J Worman, Leslie B Gordon, Karima Djabali   +8 more
doaj   +1 more source

Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 [PDF]

, 2017
We thank Zhen-Yuan Lin for help in the preparation of the AP-MS samples, and Cathy Collins for technical assistance. MDL is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), LEC is supported by a Canada Research Chair in ...
Bohovych, Iryna, Cowen, Leah E., Gingras, Anne-Claude, Khalimonchuk, Oleh, Lambert, Jean-Philippe, Leach, Michelle, Wong, Erin O Y, Xie, Jinglin L   +7 more
core   +4 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Weekly paclitaxel, gemcitabine, and external irradiation followed by randomized farnesyl transferase inhibitor R115777 for locally advanced pancreatic cancer. [PDF]

, 2012
PURPOSE: The Radiation Therapy Oncology Group (RTOG) multi-institutional Phase II study 98-12, evaluating paclitaxel and concurrent radiation (RT) for locally advanced pancreatic cancer, demonstrated a median survival of 11.3 months and a 1-year survival
Anne, Pramila R, Cline-Burkhardt, Vivian Jm, Erickson, Beth, Hoffman, John P, Myerson, Robert J, Perez, Kimberly, Rich, Tyvin A, Safran, Howard, Willett, Christopher, Winter, Kathryn   +9 more
core   +1 more source

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, Volume 3, Issue 6, November 2025.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Exploitation of host polyubiquitination machinery through molecular mimicry by eukaryotic-like bacterial F-box effectors

Frontiers in Cellular and Infection Microbiology, 2010
Microbial pathogens have evolved exquisite mechanisms to interfere and intercept host biological processes, often through molecular mimicry of specific host proteins.
Yousef eAbu Kwaik, Christopher T. Price
doaj   +1 more source

Host-mediated post-translational prenylation of novel Dot/Icm-translocated effectors of Legionella pneumophila

Frontiers in Cellular and Infection Microbiology, 2010
The Dot/Icm type IV translocated Ankyrin B (AnkB) effector of Legionella pneumophila is modified by the host prenylation machinery that anchors it into the outer leaflet of the Legionella-containing vacuole (LCV), which is essential for biological ...
Christopher T Price, Snake C Jones, Karen E Amundson, Yousef eAbu Kwaik   +3 more
doaj   +1 more source

Human Hsp40 proteins, DNAJA1 and DNAJA2, as potential targets of the immune response triggered by bacterial DnaJ in rheumatoid arthritis [PDF]

, 2013
Hsp40 proteins of bacterial and human origin are suspected to be involved in the pathogenesis of rheumatoid arthritis (RA). It has been shown that sera of RA patients contain increased levels of antibodies directed to bacterial and human Hsp40s.
Agnieszka Kotlarz, Barbara Lipinska, Elzbieta Brycka, Konrad Krzewski, Stefan Tukaj   +4 more
core   +1 more source