Results 21 to 30 of about 97,027 (306)

Necrotic Death Pathway in FAS Receptor Signaling [PDF]

The Journal of Cell Biology, 2000
A caspase 8–deficient subline (JB6) of human Jurkat cells can be killed by the oligomerization of Fas-associated protein with death domain (FADD). This cell death process is not accompanied by caspase activation, but by necrotic morphological changes.
H, Matsumura, Y, Shimizu, Y, Ohsawa, A, Kawahara, Y, Uchiyama, S, Nagata   +5 more
openaire   +2 more sources

The FAS-receptors of apoptosis expression on the medulloblastomas cells

Ukrainian Neurosurgical Journal, 2005
The Fas-receptor of apoptosis expression on the living medulloblastomas cells was determined. Fas-receptor of apoptosis was expressed on 4–48,8% tumors cells.
Yu. A. Orlov, A. N. Lisyany, A. V. Shaversky, T. A. Malysheva, O. G. Chernenko, L. I. Primushko   +5 more
doaj   +1 more source

Fas (CD95) induces rapid, TLR4/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages

Journal of Inflammation, 2010
Although Fas (CD95) is recognized as a death receptor that induces apoptosis, recent studies indicate that the Fas/FasL system can induce pro-inflammatory cytokine production by macrophages independent of conventional caspase-mediated apoptotic signaling.
Kain Kevin C, Yang Huan, Hawkes Michael, Lu Ziyue, Wang Feng, Liles W Conrad   +5 more
doaj   +1 more source

Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase1

Journal of Lipid Research, 2006
We discovered a nuclear receptor element in the FAS promoter consisting of an inverted repeat spaced by one nucleotide (IR-1) and located 21 bases downstream of a direct repeat sequenced by 4 nucleotides (DR-4) oxysterol liver X receptor response element.
Karen E. Matsukuma, Mary K. Bennett, Jiansheng Huang, Li Wang, Gregorio Gil, Timothy F. Osborne   +5 more
doaj   +1 more source

Molecular dynamics simulation of Fe-NO2 At-alpha mangostin as radiopharmaceutical model for detection of fatty acid synthase in cancer

Journal of Advanced Pharmaceutical Technology & Research, 2021
α-mangostin is a xanthone compound isolated from mangosteen pericarp. It is known as an anticancer through induction of apoptotic process by inhibiting fatty acid synthase (FAS) receptor. α-mangostin is a potentially useful ligand for diagnostic purposes
N Elly Rosilawati, Muhamad Yusuf, Achmad Hussein S. Kartamihardja, Shaharum Samsuddin, Muchtaridi Muchtaridi   +4 more
doaj   +1 more source

Expression of TRAIL and Fas in Primary Hyperparathyroidism

Journal of Investigative Surgery, 2017
Aim: Differentiating between parathyroid lesions is still difficult and ambiguous. In cases of primary hyperparathyroidism, appropriate and prompt diagnosis is of great importance for effective treatment and follow-up.
Oliwia Anna Segiet, Mariusz Deska, Łukasz Mielańczyk, Marlena Brzozowa-Zasada, Grzegorz Buła, Jacek Gawrychowski, Romuald Wojnicz   +6 more
doaj   +1 more source

Neonatal mice lacking functional Fas death receptors are resistant to hypoxic–ischemic brain injury

Neurobiology of Disease, 2004
Neonatal hypoxia–ischemia (HI) upregulates Fas death receptor expression in the brain, and alterations in expression and activity of Fas signaling intermediates occur in neonatal brain injury. B6.MRL-Tnfrsf6lpr mice lacking functional Fas death receptors
Ernest M. Graham, R.Ann Sheldon, Debra L. Flock, Donna M. Ferriero, Lee J. Martin, Declan P. O'Riordan, Frances J. Northington   +6 more
doaj   +1 more source

The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin. [PDF]

PLoS ONE, 2009
BACKGROUND: The efficacy of oxaliplatin in cancer chemotherapy is limited by the development of drug resistance. MMP7 has been related to the loss of tumor cell response to cytotoxic agents although the exact mechanism is not fully understood.
Vanessa Almendro, Elisabet Ametller, Susana García-Recio, Olga Collazo, Ignasi Casas, Josep M Augé, Joan Maurel, Pedro Gascón   +7 more
doaj   +1 more source

Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions

iScience, 2021
Summary: VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary deaf blindness in Usher syndrome 2C and haploinsufficiency of VLGR1 is ...
Deva K. Kusuluri, Baran E. Güler, Barbara Knapp, Nicola Horn, Karsten Boldt, Marius Ueffing, Gabriela Aust, Uwe Wolfrum   +7 more
doaj   +1 more source

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells. [PDF]

PLoS ONE, 2009
BACKGROUND: Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis.
Consuelo Gajate, Fernando Gonzalez-Camacho, Faustino Mollinedo   +2 more
doaj   +1 more source