Results 151 to 160 of about 20,213 (210)

Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens. [PDF]

Braz J Med Biol Res
Medina-Saldivar C, Pardo GVE, Pacheco-Otalora LF.   +2 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

The fatty acid amide hydrolase (FAAH)

Chemistry and Physics of Lipids, 2000
The topic of this review is fatty acid amide hydrolase (FAAH), one of the best-characterized enzymes involved in the hydrolysis of bioactive lipids such as anandamide, 2-arachidonoylglycerol (2-AG), and oleamide. Herein, we discuss the nomenclature, the various assays that have been developed, the relative activity of the various substrates and the ...
Dale G Deutsch, Natsuo Ueda, Shozo Yamamoto   +2 more
exaly   +3 more sources

Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective

Cannabis & Cannabinoid Research, 2023
Introduction: Fatty acid amide hydrolase (FAAH) is one of the main terminating enzymes of the endocannabinoid system (ECS). Since being discovered in 1996, the modulation of FAAH has been viewed as a compelling alternative strategy to obtain the beneficial effect of the ECS.
Anugrah D. Santoso, Dirk De Ridder
openaire   +3 more sources

STRUCTURE AND FUNCTION OF FATTY ACID AMIDE HYDROLASE

Annual Review of Biochemistry, 2005
▪ Abstract  Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide.
Michele K, McKinney, Benjamin F, Cravatt
openaire   +3 more sources

Fatty Acid Amide Hydrolase: From Characterization to Therapeutics

Chemistry and Biodiversity, 2007
AbstractFatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase‐signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of ...
Catherine Michaux
exaly   +4 more sources

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

Bioorganic and Medicinal Chemistry Letters, 2008
A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented.
Lin Luo, Richard Apodaca, John M Keith
exaly   +3 more sources

Design and synthesis of new carbamates as inhibitors for fatty acid amide hydrolase and cholinesterases: Molecular dynamic, in vitro and in vivo studies

Bioorganic Chemistry, 2021
As anandamide (N-arachidonoylethanolamine, AEA) shows neuroprotective effects, the inhibition of its degradative enzyme, fatty acid amide hydrolase (FAAH) has been considered as a hopeful avenue for the treatment of neurodegenerative diseases, like ...
Razieh Ghodsi, Hamid Nadri, Najmeh Edraki   +2 more
exaly   +2 more sources

Anticancer Potential of Small‐Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase

ChemMedChem, 2021
Recently fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitors have been in the limelight due to their anticancer potential. Both FAAH and MAGL are the endocannabinoid degrading enzymes that hydrolyze several endogenous ligands,
Senthil Raja Ayyannan, Shivani Jaiswal
exaly   +2 more sources