Results 171 to 180 of about 22,778 (210)

The fatty acid amide hydrolase (FAAH)

Chemistry and Physics of Lipids, 2000
The topic of this review is fatty acid amide hydrolase (FAAH), one of the best-characterized enzymes involved in the hydrolysis of bioactive lipids such as anandamide, 2-arachidonoylglycerol (2-AG), and oleamide. Herein, we discuss the nomenclature, the various assays that have been developed, the relative activity of the various substrates and the ...
N, Ueda, R A, Puffenbarger, S, Yamamoto, D G, Deutsch   +3 more
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Plant fatty acid (ethanol) amide hydrolases

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006
Fatty acid amide hydrolase (FAAH) plays a central role in modulating endogenous N-acylethanolamine (NAE) levels in vertebrates, and, in part, constitutes an "endocannabinoid" signaling pathway that regulates diverse physiological and behavioral processes in animals.
Rhidaya, Shrestha, Sang-chul, Kim, John M, Dyer, Richard A, Dixon, Kent D, Chapman   +4 more
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Novel inhibitors of fatty acid amide hydrolase

Bioorganic & Medicinal Chemistry Letters, 2007
A class of bisarylimidazole derivatives are identified as potent inhibitors of the enzyme fatty acid amide hydrolase (FAAH). Compound 17 (IC(50)=2 nM) dose-dependently (0.1-10mg/kg, iv) potentiates the effects of exogenous anandamide (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in animal models
S Y, Sit, Charlie, Conway, Robert, Bertekap, Kai, Xie, Clotilde, Bourin, Kevin, Burris, Hongfeng, Deng   +6 more
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Fatty Acid Amide Hydrolase: From Characterization to Therapeutics

Chemistry & Biodiversity, 2007
AbstractFatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase‐signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of ...
Labar, Geoffray, Michaux, Catherine
openaire   +3 more sources

Fatty Acid Amide Hydrolase Inhibitors – Progress and Potential

CNS & Neurological Disorders - Drug Targets, 2011
Fatty acid amide hydrolase (FAAH) is responsible for hydrolysis of endocannabinoid, anandamide (AEA), and N-acyl ethanolamines such as palmitoylethanolamine (PEA) and N-oleoylethanolamide (OEA). Genetic deletion or pharmacological inactivation of FAAH shows site-specific elevation of AEA that plays a role in the modulation of pain and other ...
Khanna, Ish K., Alexander, Christopher W.   +1 more
openaire   +3 more sources

Novel propanamides as fatty acid amide hydrolase inhibitors

European Journal of Medicinal Chemistry, 2017
Fatty acid amide hydrolase (FAAH) has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol. FAAH inhibition represents a promising strategy to activate the cannabinoid system, since it does not result in the psychotropic and peripheral side effects ...
Alessandro Deplano, Carmine Marco Morgillo, Monica Demurtas, Emmelie Björklund, Mariateresa Cipriano, Mona Svensson, Sanaz Hashemian, Giovanni Smaldone, Emilia Pedone, F. Javier Luque, Maria G. Cabiddu, Ettore Novellino, Christopher J. Fowler, Bruno Catalanotti, Valentina Onnis   +14 more
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Fatty acid amide hydrolase, anandamide, and neurological diseases

2023
The endocannabinoid anandamide (N-arachidonoylethanolamine, AEA) is a bioactive lipid that has been shown to regulate a number of important pathophysiological conditions in humans, including several neurological disorders. AEA acts on cannabinoid receptors, and many studies reported that it may also interact with other targets, such as vanilloid and ...
F. Fezza, E. Criscuolo, M. L. De Sciscio, M. Maccarrone   +3 more
openaire   +1 more source

Fatty Acid Amide Hydrolase Inhibition by Neurotoxic Organophosphorus Pesticides

Toxicology and Applied Pharmacology, 2001
Organophosphorus (OP) compound-induced inhibition of acetylcholinesterase (AChE) and neuropathy target esterase explains the rapid onset and delayed neurotoxic effects, respectively, for OP insecticides and related compounds but apparently not a third or intermediate syndrome with delayed onset and reduced limb mobility.
G B, Quistad, S E, Sparks, J E, Casida
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Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases

Drug Discovery Today, 2009
Fatty acid amide hydrolase (FAAH) is responsible for the hydrolysis of several important endogenous fatty acid amides (FAAs), including anandamide, oleoylethanolamide and palmitoylethanolamide. Because specific FAAs interact with cannabinoid and vanilloid receptors, they are often referred to as 'endocannabinoids' or 'endovanilloids'.
Sivaram, Pillarisetti, Christopher W, Alexander, Ish, Khanna   +2 more
openaire   +2 more sources

Fatty Acid Amide Hydrolase Controls Mouse Intestinal Motility In Vivo

Gastroenterology, 2005
Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis both of the endocannabinoids (which are known to inhibit intestinal motility) and other bioactive amides (palmitoylethanolamide, oleamide, and oleoylethanolamide), which might affect intestinal motility. The physiologic role of FAAH in the gut is largely unexplored.
CAPASSO, RAFFAELE, I. MATIAS, B. LUTZ, BORRELLI, FRANCESCA, CAPASSO, FRANCESCO, G. MARSICANO, MASCOLO, NICOLA DOMENICO, S. PETROSINO, K. MONORY, M. VALENTI, V. DI MARZO, IZZO, ANGELO ANTONIO   +11 more
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