Results 171 to 180 of about 13,359 (214)
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The fatty acid amide hydrolase (FAAH)
Chemistry and Physics of Lipids, 2000The topic of this review is fatty acid amide hydrolase (FAAH), one of the best-characterized enzymes involved in the hydrolysis of bioactive lipids such as anandamide, 2-arachidonoylglycerol (2-AG), and oleamide. Herein, we discuss the nomenclature, the various assays that have been developed, the relative activity of the various substrates and the ...
Natsuo Ueda +2 more
exaly +3 more sources
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase
Bioorganic and Medicinal Chemistry Letters, 2008A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented.
John M Keith, Richard Apodaca, Lin Luo
exaly +3 more sources
Fatty Acid Amide Hydrolase Inhibitors – Progress and Potential
CNS & Neurological Disorders - Drug Targets, 2011 Fatty acid amide hydrolase (FAAH) is responsible for hydrolysis of endocannabinoid, anandamide (AEA), and N-acyl ethanolamines such as palmitoylethanolamine (PEA) and N-oleoylethanolamide (OEA). Genetic deletion or pharmacological inactivation of FAAH shows site-specific elevation of AEA that plays a role in the modulation of pain and other ...
Khanna, Ish K. +1 more
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Transcriptional regulation of the mouse fatty acid amide hydrolase gene
Gene, 2002Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme that inactivates a family of fatty acid amide molecules which are implicated in physiological processes such as pain and sleep. We cloned a 1.9 kb fragment of the 5'-untranslated region of the mouse FAAH gene into the pGL3 basic luciferase reporter vector and showed that this sequence has ...
Akira Terao +2 more
exaly +3 more sources
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase
Bioorganic and Medicinal Chemistry Letters, 2010 A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system.
Sabrina Dallavalle +2 more
exaly +3 more sources
The fatty acid amide hydrolase (FAAH)
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002The fatty acid amide hydrolase (FAAH), is the enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. The FAAH knockout, the assays for FAAH, the activity of its substrates, its reversibility and its cloning from rat, mouse, human, and pig are covered in this review.
D G, Deutsch, N, Ueda, S, Yamamoto
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STRUCTURE AND FUNCTION OF FATTY ACID AMIDE HYDROLASE
Annual Review of Biochemistry, 2005▪ Abstract Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide.
Michele K, McKinney, Benjamin F, Cravatt
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Anandamide amidohydrolase (fatty acid amide hydrolase)
Prostaglandins & Other Lipid Mediators, 2000Anandamide (N-arachidonoylethanolamine) loses its cannabimimetic activity when it is hydrolyzed to arachidonic acid and ethanolamine by the catalysis of an enzyme referred to as anandamide amidohydrolase or fatty acid amide hydrolase. Cravatt's group and our group cloned cDNA of the enzyme from rat, human, mouse and pig, and the primary structures ...
N, Ueda, S, Yamamoto
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Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective
Cannabis & Cannabinoid Research, 2023Introduction: Fatty acid amide hydrolase (FAAH) is one of the main terminating enzymes of the endocannabinoid system (ECS). Since being discovered in 1996, the modulation of FAAH has been viewed as a compelling alternative strategy to obtain the beneficial effect of the ECS.
Anugrah D. Santoso, Dirk De Ridder
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Fatty acid amide hydrolase substrate specificity
Bioorganic & Medicinal Chemistry Letters, 2000Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers.
D L, Boger +5 more
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