Results 161 to 170 of about 22,778 (210)

Endocannabinoid and exercise [PDF]

Rajala, Eveliina
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Physiological roles of fatty acids and endocannabinoids in the nematode Caenorhabditis elegans [PDF]

Reisner, Kaja
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STRUCTURE AND FUNCTION OF FATTY ACID AMIDE HYDROLASE

Annual Review of Biochemistry, 2005
▪ Abstract  Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide.
Michele K, McKinney, Benjamin F, Cravatt
openaire   +4 more sources

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

Bioorganic & Medicinal Chemistry Letters, 2008
A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented.
John M, Keith, Richard, Apodaca, Wei, Xiao, Mark, Seierstad, Kanaka, Pattabiraman, Jiejun, Wu, Michael, Webb, Mark J, Karbarz, Sean, Brown, Sandy, Wilson, Brian, Scott, Chui-Se, Tham, Lin, Luo, James, Palmer, Michelle, Wennerholm, Sandra, Chaplan, J Guy, Breitenbucher   +16 more
openaire   +4 more sources

Inhibitor of Fatty Acid Amide Hydrolase — Learning from Tragic Failures

New England Journal of Medicine, 2017
A large number of drugs can induce prolongation of cardiac repolarization and life-threatening cardiac arrhythmias. The prediction of this side effect is however challenging as it usually develops in some genetically predisposed individuals with normal cardiac repolarization at baseline. Here, we describe a platform based on a genetically diverse panel
Michael, Schapira, Bénédicte, De Vroey, Jean-Michel, Ghilain   +2 more
openaire   +9 more sources

Fatty acid amide hydrolase inhibitors and the marijuana debate

The Lancet, 2001
D, Gurwitz, A, Weizman
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Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective

Cannabis and Cannabinoid Research, 2023
Introduction: Fatty acid amide hydrolase (FAAH) is one of the main terminating enzymes of the endocannabinoid system (ECS). Since being discovered in 1996, the modulation of FAAH has been viewed as a compelling alternative strategy to obtain the beneficial effect of the ECS.
Anugrah D. Santoso, Dirk De Ridder
openaire   +2 more sources

Fatty acid amide hydrolase substrate specificity

Bioorganic & Medicinal Chemistry Letters, 2000
Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers.
D L, Boger, R A, Fecik, J E, Patterson, H, Miyauchi, M P, Patricelli, B F, Cravatt   +5 more
openaire   +2 more sources

Anandamide amidohydrolase (fatty acid amide hydrolase)

Prostaglandins & Other Lipid Mediators, 2000
Anandamide (N-arachidonoylethanolamine) loses its cannabimimetic activity when it is hydrolyzed to arachidonic acid and ethanolamine by the catalysis of an enzyme referred to as anandamide amidohydrolase or fatty acid amide hydrolase. Cravatt's group and our group cloned cDNA of the enzyme from rat, human, mouse and pig, and the primary structures ...
N, Ueda, S, Yamamoto
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The fatty acid amide hydrolase (FAAH)

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
The fatty acid amide hydrolase (FAAH), is the enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. The FAAH knockout, the assays for FAAH, the activity of its substrates, its reversibility and its cloning from rat, mouse, human, and pig are covered in this review.
D G, Deutsch, N, Ueda, S, Yamamoto
openaire   +2 more sources