Results 161 to 170 of about 20,213 (210)

The role of fatty acid amide hydrolase enzyme inhibitors in Alzheimer's disease

Cell Biochemistry and Function, 2021
Fatty acid amide hydrolase (FAAH) is a prominent enzyme of the endocannabinoid system that degrades endogenous cannabinoid anandamide and oleamide. These lipid amides are involved in reducing neuroinflammation, pain and regulation of other neurological ...
Smita Jain, A. Bisht, Kanika Verma, Swarnima Negi, Sarvesh Paliwal, Swapnil Sharma   +5 more
semanticscholar   +1 more source

The fatty acid amide hydrolase (FAAH)

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
The fatty acid amide hydrolase (FAAH), is the enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. The FAAH knockout, the assays for FAAH, the activity of its substrates, its reversibility and its cloning from rat, mouse, human, and pig are covered in this review.
D G, Deutsch, N, Ueda, S, Yamamoto
openaire   +2 more sources

Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial.

Lancet psychiatry, 2019
BACKGROUND Cannabis is one of the most widely used drugs worldwide. Cannabis use disorder is characterised by recurrent use of cannabis that causes significant clinical and functional impairment.
D. D’Souza, J. Cortes-Briones, Gina M Creatura, Grai Bluez, Halle Thurnauer, Emma Deaso, Kim Bielen, Toral S. Surti, Rajiv Radhakrishnan, Aarti Gupta, Swapnil Gupta, J. Cahill, M. Sherif, A. Makriyannis, P. Morgan, M. Ranganathan, P. Skosnik   +16 more
semanticscholar   +1 more source

Anandamide amidohydrolase (fatty acid amide hydrolase)

Prostaglandins & Other Lipid Mediators, 2000
Anandamide (N-arachidonoylethanolamine) loses its cannabimimetic activity when it is hydrolyzed to arachidonic acid and ethanolamine by the catalysis of an enzyme referred to as anandamide amidohydrolase or fatty acid amide hydrolase. Cravatt's group and our group cloned cDNA of the enzyme from rat, human, mouse and pig, and the primary structures ...
N, Ueda, S, Yamamoto
openaire   +2 more sources

A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents.

European journal of medicinal chemistry, 2019
Fatty acid amide hydrolase (FAAH) is an important enzyme creditworthy of hydrolyzing endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered novel arena of pharmacological canvasses to unwrap its curative potency in ...
R. Tripathi
semanticscholar   +1 more source

Advances in the discovery of fatty acid amide hydrolase inhibitors: what does the future hold?

Expert Opinion on Drug Discovery, 2020
Introduction Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme, that inactivates endogenous signaling lipids of the fatty acid amide family, including the endocannabinoid anandamide (N-arachidonoylethanolamine, AEA).
Domenico Fazio, Emanuele Criscuolo, Alessandra Piccoli, B. Barboni, F. Fezza, M. Maccarrone   +5 more
semanticscholar   +1 more source

Fatty acid amide hydrolase substrate specificity

Bioorganic & Medicinal Chemistry Letters, 2000
Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers.
D L, Boger, R A, Fecik, J E, Patterson, H, Miyauchi, M P, Patricelli, B F, Cravatt   +5 more
openaire   +2 more sources

Plant fatty acid (ethanol) amide hydrolases

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006
Fatty acid amide hydrolase (FAAH) plays a central role in modulating endogenous N-acylethanolamine (NAE) levels in vertebrates, and, in part, constitutes an "endocannabinoid" signaling pathway that regulates diverse physiological and behavioral processes in animals.
Rhidaya, Shrestha, Sang-chul, Kim, John M, Dyer, Richard A, Dixon, Kent D, Chapman   +4 more
openaire   +2 more sources

Novel inhibitors of fatty acid amide hydrolase

Bioorganic & Medicinal Chemistry Letters, 2007
A class of bisarylimidazole derivatives are identified as potent inhibitors of the enzyme fatty acid amide hydrolase (FAAH). Compound 17 (IC(50)=2 nM) dose-dependently (0.1-10mg/kg, iv) potentiates the effects of exogenous anandamide (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in animal models
S Y, Sit, Charlie, Conway, Robert, Bertekap, Kai, Xie, Clotilde, Bourin, Kevin, Burris, Hongfeng, Deng   +6 more
openaire   +2 more sources

Pharmacological Activity of Fatty Acid Amides Is Regulated, but Not Mediated, by Fatty Acid Amide Hydrolase in Vivo

The Journal of Pharmacology and Experimental Therapeutics, 2002
Fatty acid amides (FAAs) represent a class of neuromodulatory lipids that includes the endocannabinoid anandamide and the sleep-inducing substance oleamide. Both anandamide and oleamide produce behavioral effects indicative of cannabinoid activity, but only anandamide binds the cannabinoid (CB1) receptor in vitro.
Aron H, Lichtman, E Gregory, Hawkins, Graeme, Griffin, Benjamin F, Cravatt   +3 more
openaire   +2 more sources