Results 181 to 190 of about 13,359 (214)

Plant fatty acid (ethanol) amide hydrolases

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006
Fatty acid amide hydrolase (FAAH) plays a central role in modulating endogenous N-acylethanolamine (NAE) levels in vertebrates, and, in part, constitutes an "endocannabinoid" signaling pathway that regulates diverse physiological and behavioral processes in animals.
Rhidaya, Shrestha, Sang-chul, Kim, John M, Dyer, Richard A, Dixon, Kent D, Chapman   +4 more
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Novel inhibitors of fatty acid amide hydrolase

Bioorganic & Medicinal Chemistry Letters, 2007
A class of bisarylimidazole derivatives are identified as potent inhibitors of the enzyme fatty acid amide hydrolase (FAAH). Compound 17 (IC(50)=2 nM) dose-dependently (0.1-10mg/kg, iv) potentiates the effects of exogenous anandamide (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in animal models
S Y, Sit, Charlie, Conway, Robert, Bertekap, Kai, Xie, Clotilde, Bourin, Kevin, Burris, Hongfeng, Deng   +6 more
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Pharmacological Activity of Fatty Acid Amides Is Regulated, but Not Mediated, by Fatty Acid Amide Hydrolase in Vivo

The Journal of Pharmacology and Experimental Therapeutics, 2002
Fatty acid amides (FAAs) represent a class of neuromodulatory lipids that includes the endocannabinoid anandamide and the sleep-inducing substance oleamide. Both anandamide and oleamide produce behavioral effects indicative of cannabinoid activity, but only anandamide binds the cannabinoid (CB1) receptor in vitro.
Aron H, Lichtman, E Gregory, Hawkins, Graeme, Griffin, Benjamin F, Cravatt   +3 more
openaire   +2 more sources

Novel propanamides as fatty acid amide hydrolase inhibitors

European Journal of Medicinal Chemistry, 2017
Fatty acid amide hydrolase (FAAH) has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol. FAAH inhibition represents a promising strategy to activate the cannabinoid system, since it does not result in the psychotropic and peripheral side effects ...
Alessandro Deplano, Carmine Marco Morgillo, Monica Demurtas, Emmelie Björklund, Mariateresa Cipriano, Mona Svensson, Sanaz Hashemian, Giovanni Smaldone, Emilia Pedone, F. Javier Luque, Maria G. Cabiddu, Ettore Novellino, Christopher J. Fowler, Bruno Catalanotti, Valentina Onnis   +14 more
openaire   +5 more sources

Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases

Drug Discovery Today, 2009
Fatty acid amide hydrolase (FAAH) is responsible for the hydrolysis of several important endogenous fatty acid amides (FAAs), including anandamide, oleoylethanolamide and palmitoylethanolamide. Because specific FAAs interact with cannabinoid and vanilloid receptors, they are often referred to as 'endocannabinoids' or 'endovanilloids'.
Sivaram, Pillarisetti, Christopher W, Alexander, Ish, Khanna   +2 more
openaire   +2 more sources

Analysis of Fatty Acid Amide Hydrolase Activity in Plants

2013
N-Acylethanolamines (NAEs) are fatty acid derivatives amide-linked to ethanolamine. NAEs vary in chain lengths and numbers of double bonds and generally reflect the fatty acids found in membrane lipids in the tissues in which they reside. NAEs are present naturally in trace amounts and occur in a wide range of organisms including plants, animals, and ...
Sang-Chul, Kim, Lionel, Faure, Kent D, Chapman   +2 more
openaire   +2 more sources

Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase

Bioorganic & Medicinal Chemistry Letters, 2005
A novel series of heterocyclic sulfoxides and sulfones was prepared and examined as potential inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for inactivation of neuromodulating fatty acid amides including anandamide and oleamide.
Wu, Du, Christophe, Hardouin, Heng, Cheng, Inkyu, Hwang, Dale L, Boger   +4 more
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Arachidonoylserotonin and Other Novel Inhibitors of Fatty Acid Amide Hydrolase

Biochemical and Biophysical Research Communications, 1998
Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis of bioactive fatty acid amides and esters such as the endogenous cannabinoid receptor ligands, anandamide (N-arachidonoyl-ethanolamine) and 2-arachidonoylglycerol, and the putative sleep inducing factor cis-9-octadecenoamide (oleamide).
Bisogno T, Melck D, De Petrocellis L, Bobrov MYu, Gretskaya NM, Bezuglov VV, Sitachitta N, Gerwick WH, Di Marzo V   +8 more
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Erratum to “The fatty acid amide hydrolase (FAAH)”

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
Erratum to ‘‘The fatty acid amide hydrolase (FAAH)’’ Prostaglandins Leukot. Essent. Fatty Acids 66(2–3) (2002) 201–210 D.G. Deutsch*, N. Ueda, S. Yamamoto Department of Biochemistry and Cellular Biology, State University of New York at Stony Brook Life Sciences Building, Stony Brook, NY 11794-5215, USA Department of Biochemistry and Cell Biology ...
D.G. Deutsch, N. Ueda, S. Yamamoto
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Latest advances in the discovery of fatty acid amide hydrolase inhibitors

Expert Opinion on Drug Discovery, 2013
Fatty acid amide hydrolase (FAAH) is the major catabolic enzyme of the endocannabinoid N-arachidonoylethanolamine (anandamide) that, with different degrees of efficiency, also hydrolyzes other endogenous fatty acid ethanolamides. FAAH is increasingly being considered a relevant therapeutic target, especially in models of inflammatory pain.
Bisogno T, Maccarrone M
openaire   +5 more sources