Results 181 to 190 of about 22,623 (220)

Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases

Drug Discovery Today, 2009
Fatty acid amide hydrolase (FAAH) is responsible for the hydrolysis of several important endogenous fatty acid amides (FAAs), including anandamide, oleoylethanolamide and palmitoylethanolamide. Because specific FAAs interact with cannabinoid and vanilloid receptors, they are often referred to as 'endocannabinoids' or 'endovanilloids'.
Sivaram, Pillarisetti, Christopher W, Alexander, Ish, Khanna   +2 more
openaire   +2 more sources

Fatty Acid Amide Hydrolase Controls Mouse Intestinal Motility In Vivo

Gastroenterology, 2005
Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis both of the endocannabinoids (which are known to inhibit intestinal motility) and other bioactive amides (palmitoylethanolamide, oleamide, and oleoylethanolamide), which might affect intestinal motility. The physiologic role of FAAH in the gut is largely unexplored.
CAPASSO, RAFFAELE, I. MATIAS, B. LUTZ, BORRELLI, FRANCESCA, CAPASSO, FRANCESCO, G. MARSICANO, MASCOLO, NICOLA DOMENICO, S. PETROSINO, K. MONORY, M. VALENTI, V. DI MARZO, IZZO, ANGELO ANTONIO   +11 more
openaire   +6 more sources

Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase

Bioorganic & Medicinal Chemistry Letters, 2005
A novel series of heterocyclic sulfoxides and sulfones was prepared and examined as potential inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for inactivation of neuromodulating fatty acid amides including anandamide and oleamide.
Wu, Du, Christophe, Hardouin, Heng, Cheng, Inkyu, Hwang, Dale L, Boger   +4 more
openaire   +2 more sources

Arachidonoylserotonin and Other Novel Inhibitors of Fatty Acid Amide Hydrolase

Biochemical and Biophysical Research Communications, 1998
Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis of bioactive fatty acid amides and esters such as the endogenous cannabinoid receptor ligands, anandamide (N-arachidonoyl-ethanolamine) and 2-arachidonoylglycerol, and the putative sleep inducing factor cis-9-octadecenoamide (oleamide).
Bisogno T, Melck D, De Petrocellis L, Bobrov MYu, Gretskaya NM, Bezuglov VV, Sitachitta N, Gerwick WH, Di Marzo V   +8 more
openaire   +2 more sources

Analysis of Fatty Acid Amide Hydrolase Activity in Plants

2013
N-Acylethanolamines (NAEs) are fatty acid derivatives amide-linked to ethanolamine. NAEs vary in chain lengths and numbers of double bonds and generally reflect the fatty acids found in membrane lipids in the tissues in which they reside. NAEs are present naturally in trace amounts and occur in a wide range of organisms including plants, animals, and ...
Sang-Chul, Kim, Lionel, Faure, Kent D, Chapman   +2 more
openaire   +2 more sources

Erratum to “The fatty acid amide hydrolase (FAAH)”

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
Erratum to ‘‘The fatty acid amide hydrolase (FAAH)’’ Prostaglandins Leukot. Essent. Fatty Acids 66(2–3) (2002) 201–210 D.G. Deutsch*, N. Ueda, S. Yamamoto Department of Biochemistry and Cellular Biology, State University of New York at Stony Brook Life Sciences Building, Stony Brook, NY 11794-5215, USA Department of Biochemistry and Cell Biology ...
D.G. Deutsch, N. Ueda, S. Yamamoto
openaire   +1 more source

Pharmacological Activity of Fatty Acid Amides Is Regulated, but Not Mediated, by Fatty Acid Amide Hydrolase in Vivo

The Journal of Pharmacology and Experimental Therapeutics, 2002
Fatty acid amides (FAAs) represent a class of neuromodulatory lipids that includes the endocannabinoid anandamide and the sleep-inducing substance oleamide. Both anandamide and oleamide produce behavioral effects indicative of cannabinoid activity, but only anandamide binds the cannabinoid (CB1) receptor in vitro.
Aron H, Lichtman, E Gregory, Hawkins, Graeme, Griffin, Benjamin F, Cravatt   +3 more
openaire   +2 more sources

Transcriptional regulation of the mouse fatty acid amide hydrolase gene

Gene, 2002
Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme that inactivates a family of fatty acid amide molecules which are implicated in physiological processes such as pain and sleep. We cloned a 1.9 kb fragment of the 5'-untranslated region of the mouse FAAH gene into the pGL3 basic luciferase reporter vector and showed that this sequence has ...
N S, Waleh, B F, Cravatt, A, Apte-Deshpande, A, Terao, T S, Kilduff   +4 more
openaire   +2 more sources

Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)

Bioorganic & Medicinal Chemistry Letters, 2008
Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats.
Amy, Timmons, Mark, Seierstad, Rich, Apodaca, Matt, Epperson, Dan, Pippel, Sean, Brown, Leon, Chang, Brian, Scott, Michael, Webb, Sandra R, Chaplan, J Guy, Breitenbucher   +10 more
openaire   +2 more sources

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors

Bioorganic & Medicinal Chemistry Letters, 2011
Starting from a series of ureas that were determined to be mechanism-based inhibitors of FAAH, several spirocyclic ureas and lactams were designed and synthesized. These efforts identified a series of novel, noncovalent FAAH inhibitors with in vitro potency comparable to known covalent FAAH inhibitors.
Darin J, Gustin, Zhihua, Ma, Xiaoshan, Min, Yihong, Li, Christine, Hedberg, Cris, Guimaraes, Amy C, Porter, Michelle, Lindstrom, Dianna, Lester-Zeiner, Guifen, Xu, Timothy J, Carlson, Shouhua, Xiao, Cesar, Meleza, Richard, Connors, Zhulun, Wang, Frank, Kayser   +15 more
openaire   +2 more sources