Results 91 to 100 of about 2,715,237 (202)

Identification and Functional Characterization of Genes Encoding Omega-3 Polyunsaturated Fatty Acid Biosynthetic Activities from Unicellular Microalgae

Marine Drugs, 2013
In order to identify novel genes encoding enzymes involved in the biosynthesis of nutritionally important omega-3 long chain polyunsaturated fatty acids, a database search was carried out in the genomes of the unicellular photoautotrophic green alga ...
Royah Vaezi, Johnathan A. Napier, Olga Sayanova   +2 more
doaj   +1 more source

Neutrophil‐based immunotherapy: A metabolic lens on mechanisms and therapeutic implications

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
TAN metabolic reprogramming critically contributes to tumour immune evasion. A 4‑Tier TAN‑MetaC classification framework is proposed, along with an overview of translational opportunities and bottlenecks for TAN metabolism‑targeted immunotherapies. Abstract Background Tumor‐associated neutrophils (TANs) serve as pivotal immune modulators in the tumor ...
Wenchao Xu, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +4 more
wiley   +1 more source

Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty acid concentrations and percentage composition in children. [PDF]

, 2011
Tracking of fatty acid (FA) contribution to plasma or serum lipids over time was shown in children and adults. However, the potential role of FADS gene variants has not been investigated.
Demmelmair Hans, Berthold Koletzko, Rzehak, P., Claudia Glaser, Peter Rzehak, Joachim Heinrich, Heinrich, Joachim, Glaser, C., Glaser, Claudia, Heinrich, J., LISA study group, Klopp Norman, Demmelmair, Hans, Klopp, N., Rzehak, Peter, Demmelmair, H., Koletzko Berthold, Rzehak Peter, Glaser Claudia, LISAplus Study Group (Wichmann, H.-E. ; Heinrich, J. ; Bolte, G. ; Belcredi, P. ; Jacob, B. ; Schoetzau, A. ; Mosetter, M. ; Schindler, J. ; Höhnke, A.), Hans Demmelmair, null null, Norman Klopp, Heinrich Joachim, Koletzko, Berthold, Klopp, Norman, Koletzko, B., Glaser, C;Rzehak, P;Demmelmair, H;Klopp, N;Heinrich, J;Koletzko, B   +27 more
core   +1 more source

Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity

Journal of Lipid Research, 2006
Fatty acid elongases and desaturases play an important role in hepatic and whole body lipid composition. We examined the role that key transcription factors played in the control of hepatic elongase and desaturase expression.
Yun Wang, Daniela Botolin, Jinghua Xu, Barbara Christian, Ernestine Mitchell, Bolleddula Jayaprakasam, Muraleedharan Nair, Jeffery M. Peters, Julia Busik, L. Karl Olson, Donald B. Jump   +10 more
doaj   +1 more source

Transcriptomic Profiling and Gene Disruption Revealed that Two Genes Related to PUFAs/DHA Biosynthesis May be Essential for Cell Growth of Aurantiochytrium sp.

Marine Drugs, 2018
Aurantiochytrium sp. PKU#SW7 is a thraustochytrid strain that was found to exhibit high potential for docosahexaenoic acid (DHA, C22:6n-3) production. In this work, the transcriptome of Aurantiochytrium sp.
Yuanmei Liang, Ying Liu, Jie Tang, Jiong Ma, Jay J. Cheng, Maurycy Daroch   +5 more
doaj   +1 more source

A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathology. [PDF]

Eur J Med Res, 2023
Wang X, Yu H, Gao R, Liu M, Xie W.
europepmc   +1 more source

Fatty acid composition of plasma lipids in healthy Portuguese children: Is the Mediterranean diet disappearing? [PDF]

, 2001
Background: Adults and children in Mediterranean countries are believed to consume a Mediterranean-type diet wh ich is h ig her in monounsaturated a nd n-3 polyunsaturated fatty acids than compared to central and northern parts of Europe and has ...
Feldl, Franziska, Guerra, Antonio, Koletzko, Berthold   +2 more
core   +1 more source

Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival

International Journal of Biological Sciences, 2007
Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to it.
D. Joshua Cameron , Zongzhong Tong , Zhenglin Yang , Jack Kaminoh , Shin Kamiyah , Haoyu Chen , Jiexi Zeng , Yali Chen , Ling Luo , Kang Zhang
doaj  

Fatty acid elongases 1-3 have distinct roles in mitochondrial function, growth, and lipid homeostasis in Trypanosoma cruzi. [PDF]

J Biol Chem, 2023
Pagura L, Dumoulin PC, Ellis CC, Mendes MT, Estevao IL, Almeida IC, Burleigh BA.   +6 more
europepmc   +1 more source

Meldonium-induced steatosis is associated with increased delta 6 desaturation and reduced elongation of n-6 polyunsaturated fatty acids

Liver Research
Background and objective: Metabolic associated fatty liver disease (MAFLD) is associated with abnormal lipid metabolism. Mitochondrial dysfunction is considered an important factor in the onset of MAFLD, whereas altered fatty acid composition has been ...
Bodil Bjørndal, Siri Lunde Tungland, Pavol Bohov, Magne O. Sydnes, Simon N. Dankel, Lise Madsen, Rolf K Berge   +6 more
doaj   +1 more source